Se encontró una brecha de demanda insatisfecha de visitantes a centros recreativos en Lima metropolitana de 27 000 vistas por año , se recorrió los pantanos de villa, en el cual encontró un centro de interpretación precario el cual no cuenta con la capacidad instalada para cubrir la demanda actual de visitantes ,a partir de ello se proyectó un nuevo centro de interpretación , el cual contara con los ambientes necesarios para que los visitantes puedan realizar la actividades culturales e informativas dentro de este. Una manera de incentivar el turismo en el Perú, es tener más actividades por ellos se proyectó espacios de recreación pasiva en el entorno del Centro de interpretación, y adicionalmente proyectamos una ciclovía alrededor del lago, con la finalidad de crear dinamismo en el espacio público. Se aplicó la Arquitectura biofílica a la propuesta, incorporando material...

Objective: Soluble antigens of ABO blood group system are found in the mucosa, this characteristic is called secretor status, has been associated with various pathological conditions and is determined by the allele of the FUT2 gene present in the individual. The aim of the present study was to generate the first report of the secretor status in a Peruvian population. Materials and Methods: 102 undergraduate students were selected, requesting their consent to verify their blood group through direct hemagglutination and a saliva sample donation. Secretor status was determined by hemagglutination inhibition assay with saliva, being found that 5% of individuals were non-secretors. Results: Regarding the ABO system, 76% presented group O (soluble antigen H); 19%, group A and 5%, group B. Conclusion: A high frequency of the secretor phenotype was found, suggesting the importance of conducting ...

Objective: Soluble antigens of ABO blood group system are found in the mucosa, this characteristic is called secretor status, has been associated with various pathological conditions and is determined by the allele of the FUT2 gene present in the individual. The aim of the present study was to generate the first report of the secretor status in a Peruvian population. Materials and Methods: 102 undergraduate students were selected, requesting their consent to verify their blood group through direct hemagglutination and a saliva sample donation. Secretor status was determined by hemagglutination inhibition assay with saliva, being found that 5% of individuals were non-secretors. Results: Regarding the ABO system, 76% presented group O (soluble antigen H); 19%, group A and 5%, group B. Conclusion: A high frequency of the secretor phenotype was found, suggesting the importance of conducting ...

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder of vascular development. Common manifestations include epistaxis, telangiectasias and arteriovenous malformations (AVMs) in multiple organs. Most patients have deletions or missense mutations in the ENG or ACVRL1 gene respectively, significantly affecting endothelium homeostasis. We analyzed the ENG gene in five members of a Peruvian family affected by HHT. One novel mutation was found in exon four of the ENG gene c.408delA, at aminoacid residue 136. This mutation changes the subsequent reading frame producing an early stop at residue 162, preserving only one fourth of the normal protein of 658 aa. This mutation was found in the four affected members of family.

Background Breast cancer is one of the most prevalent malignancies in the world. In Peru, breast cancer is the second cause of death among women. Five to ten percent of patients present a high genetic predisposition due to BRCA 1 and BRCA 2 germline mutations. Methods We performed a comprehensive analysis of BRCA 1 and BRCA 2 genes by Sanger sequencing and multiplex ligation‐dependent probe amplification (MLPA ) to detect large rearrangements in patients from 18 families, which met the criteria for hereditary breast cancer. Results In this series, we found four pathogenic mutations, three previously reported (BRCA 1 : c.302‐1G>C and c.815_824dup10; BRCA 2 : c.5946delT) and a duplication of adenines in exon 15 in BRCA 1 gene (c.4647_4648dupAA , ClinVar SCV 000256598.1). We also found two exonic and four intronic variants of unknown significance and 28 polymorphic variants. Conclusion ...