Se identificó los factores asociados con el nivel de conocimientos y la actitud relacionados con la investigación en los estudiantes de pregrado de la carrera de medicina en Perú. Se realizó un estudio transversal analítico, aplicando un cuestionario validado sobre conocimientos, actitud y prácticas relacionados con la investigación a una muestra representativa de estudiantes de 17 facultades de medicina de Perú. Se realizó el análisis simple y bifactorial para las variables categóricas y cuantitativas, con ajuste de la correlación intraclase. Se modelaron las razones de prevalencia mediante análisis bifactorial y multifactorial con modelos lineales generalizados. Se encontró que, en general, el nivel de conocimientos sobre la investigación es deficiente y la actitud hacia ella, inadecuada. Se recomienda hacer cambios curriculares que garanticen la incorporación de los es...

Introducción: Las inmunodeficiencias primarias (IDP) son patologías de difícil diagnóstico y manejo, que suelen predisponer a infecciones respiratorias y gastrointestinales recurrentes. Reporte de caso: Paciente pediátrico con antecedente variantes patológicas de los genes IFNGR1 y TNFRSF13B, desarrolla tuberculosis de presentación atípica, caracterizada por lesiones cutáneas y sin manifestaciones respiratorias. El manejo inicial como tuberculosis atípica tuvo respuesta favorable parcial. Tras confirmación microbiológica de Mycobacterium tuberculosis, se cambió a tratamiento específico con recuperación completa. Conclusión: Las IDP predisponen a una mayor frecuencia de presentaciones atípicas de tuberculosis, dificultando el diagnostico e interfiriendo con el manejo oportuno. En el caso reportado, la ausencia en el cumplimiento de criterios clásicos de inmunodeficiencia...

Background: Primary immunodeficiencies (PID) represent challenging pathologies in terms of diagnosis and treatment, with increased predisposition to recurrent respiratory and gastrointestinal infections. Case report: A paediatric patient with pathologic variants of genes IFNGR1 and TNFRSF13B, presented an atypical manifestation of tuberculosis, characterized by cutaneous lesions and lack of respiratory symptoms. Patient was initially treated for an atypical mycobacterial infection with partial favourable response. Following microbiological confirmation of Mycobacterium tuberculosis, a proper antibiotic regimen was initiated, resulting in complete recovery. Conclusion: PIDs increase the likelihood of atypical presentations of tuberculosis, complicating diagnosis and interfering with timely treatment. We report a case lacking the classic clinical criteria for immunodeficiency and with an a...

ABSTRACT OBJECTIVE: To identify the factors associated with level of knowledge and attitudes toward research among undergraduate medical students in Peru. METHODS: In this analytical cross-sectional study, a validated questionnaire on knowledge, attitudes, and practices related to research was applied to a representative sample of students at 17 Peruvian medical schools. The categorical and quantitative variables were subjected to simple two-factor analysis with adjustment for intraclass correlation. Prevalence ratios were derived on the basis of generalized linear models using bifactorial and multifactorial analysis. RESULTS: Questionnaires from 1 554 students (51.0% women) with an average age of 20.5 ± 2.86 years were analyzed. Only 46.7% of the respondents had a good level of knowledge and 37.7% had appropriate attitudes toward research. The variables that correlated with a good leve...

ABSTRACT OBJECTIVE: To identify the factors associated with level of knowledge and attitudes toward research among undergraduate medical students in Peru. METHODS: In this analytical cross-sectional study, a validated questionnaire on knowledge, attitudes, and practices related to research was applied to a representative sample of students at 17 Peruvian medical schools. The categorical and quantitative variables were subjected to simple two-factor analysis with adjustment for intraclass correlation. Prevalence ratios were derived on the basis of generalized linear models using bifactorial and multifactorial analysis. RESULTS: Questionnaires from 1 554 students (51.0% women) with an average age of 20.5 ± 2.86 years were analyzed. Only 46.7% of the respondents had a good level of knowledge and 37.7% had appropriate attitudes toward research. The variables that correlated with a good leve...

El reordenamiento genético es la combinación de segmentos de genes que se produce por la confluencia de algunos virus de la misma especie o afines, lo cual altera la infecciosidad y el grado de patogenicidad del virus. Se produce en virus con genomas segmentados, como los del género Orthobunyavirus (familia Bunyaviridae), que incluye tres segmentos de cadena simple de ARN: el S (small), el M (médium) y el L (large), y son responsables frecuentemente de enfermedad febril aguda indiferenciada (SFAI). Este es el caso de la fiebre producida por el virus Oropuche (OROV), que ha cobrado protagonismo por recientes brotes e incremento de casos en el Perú.

El reordenamiento genético es la combinación de segmentos de genes que se produce por la cofluencia de algunos virus de la misma especie o virus, altera la infecciosidad y el grado de patogenicidad del virus.

Antimicrobial resistance (AMR) is an additional slow-evolving pandemic that precedes the COVID-19 pandemic and will continue when it ends. However, in countries such as Peru where there is high consumption and inadequate prescription of antibiotics, a more challenging future scenario can be expected. Antimicrobial Stewardship Programs (ASP) are multidisciplinary teams of professionals that aim to contain the emergence of multidrug-resistant organisms through strategies such as audit of antibiotic prescription or creating antibiotic treatment guidelines based on local AMR rates. The difficulty in the timely diagnosis of co-infections or superinfections in the clinical course of COVID-19 leads to inappropriate use of antibiotics, forcing ASP to adapt their strategies in this changing scenario. In Latin America, ASP not only has to promote behavior change in antibiotic prescribers but also ...

Congenital cytomegalovirus infection is a cause of neonatal infection that can be asymptomatic; however, its complications are possible in some organs such as the nervous system and the liver. We report a case of a 2-month-old female infant with cytomegalovirus hepatitis characterized by abdominal distention, cholestasis, irritability, and poor breastfeeding. In the tests, liver involvement, periventricular microcalcifications, and sensorineural hearing loss were found. The diagnosis was determined by serum antibodies, confirmed with viral load in blood, urine, and liver tissue. Treatment with ganciclovir, vitamin K, and ursodeoxycholic acid was administered with adequate evolution. Cytomegalovirus hepatitis is a complication that may be associated with the involvement of other organs. Antiviral treatment for liver involvement is still controversial; however, it is recommended in ...