En el Perú, el programa actual de inmunización para COVID-19 comprende las vacunas BBIBP-CorV, BNT162B2 y ChAdOx1 nCoV-19. Si bien el esquema de inmunización es de dos dosis, algunos países han incluido recientemente una dosis de refuerzo a su esquema. Métodos: Se realizó una búsqueda de evidencia científica sobre la eficacia y seguridad de la vacunación de refuerzo con la vacuna BNT162b2 en población con esquema de vacunación completa para COVID-19 en Perú. Evidencia incluida: Se consideraron cuatro documentos de recomendación basados en evidencia, un estudio observacional y tres ensayos clínicos fase III en curso. Conclusión: A la fecha, no existe evidencia suficiente sobre la eficacia de agregar una dosis de refuerzo al esquema de inmunización para COVID-19. La evidencia disponible no permite justificar el uso de una dosis de refuerzo con la vacuna BNT162B2 en poblaciÃ...

Background: In Peru, the current immunization schedule for COVID-19 includes BBIBP-CorV, BNT162B2 and ChAdOx1 nCoV-19 vaccines. Although the full immunization schedule is two doses, some countries have recently included a booster dose to their schedule. Methods: We conducted a search for scientific evidence on the efficacy and safety of booster vaccination with BNT162b2 vaccine in a population with a complete vaccination schedule for COVID-19 in Peru. Evidence: Four evidence-based recommendation documents, one observational study and three ongoing phase III clinical trials were included for analysis. Conclusion: To date, there is insufficient evidence on the efficacy of adding a booster dose to the immunization schedule for COVID-19. The available evidence does not justify the use of a booster dose of BNT162B2 vaccine in a population that has previously received two doses of the aforemen...

A health technology assessment (HTA) was carried out to critically analyze the evidence on the efficacy and safety of the surgical correction of spinal deformities using the coplanar technique, compared to the conventional derotation techniques, in children, adolescents and adults. A systematic search of the literature was carried out in the PubMed, Cochrane Library and LILACS databases. In addition, a manual search was carried out in the reference lists of the included studies, on Google and on the websites of specialized societies and groups that produce clinical practice guidelines (CPG) and HTA. In addition, we searched ClinicalTrials.gov and the International Clinical Trial Registry Platform (ICTRP) for clinical trial records in progress or not completed. Five documents were selected for evaluation, including two CPG, a randomized clinical trial, and two observational studies. After...

Se identificó los factores asociados con el nivel de conocimientos y la actitud relacionados con la investigación en los estudiantes de pregrado de la carrera de medicina en Perú. Se realizó un estudio transversal analítico, aplicando un cuestionario validado sobre conocimientos, actitud y prácticas relacionados con la investigación a una muestra representativa de estudiantes de 17 facultades de medicina de Perú. Se realizó el análisis simple y bifactorial para las variables categóricas y cuantitativas, con ajuste de la correlación intraclase. Se modelaron las razones de prevalencia mediante análisis bifactorial y multifactorial con modelos lineales generalizados. Se encontró que, en general, el nivel de conocimientos sobre la investigación es deficiente y la actitud hacia ella, inadecuada. Se recomienda hacer cambios curriculares que garanticen la incorporación de los es...

ABSTRACT OBJECTIVE: To identify the factors associated with level of knowledge and attitudes toward research among undergraduate medical students in Peru. METHODS: In this analytical cross-sectional study, a validated questionnaire on knowledge, attitudes, and practices related to research was applied to a representative sample of students at 17 Peruvian medical schools. The categorical and quantitative variables were subjected to simple two-factor analysis with adjustment for intraclass correlation. Prevalence ratios were derived on the basis of generalized linear models using bifactorial and multifactorial analysis. RESULTS: Questionnaires from 1 554 students (51.0% women) with an average age of 20.5 ± 2.86 years were analyzed. Only 46.7% of the respondents had a good level of knowledge and 37.7% had appropriate attitudes toward research. The variables that correlated with a good leve...

ABSTRACT OBJECTIVE: To identify the factors associated with level of knowledge and attitudes toward research among undergraduate medical students in Peru. METHODS: In this analytical cross-sectional study, a validated questionnaire on knowledge, attitudes, and practices related to research was applied to a representative sample of students at 17 Peruvian medical schools. The categorical and quantitative variables were subjected to simple two-factor analysis with adjustment for intraclass correlation. Prevalence ratios were derived on the basis of generalized linear models using bifactorial and multifactorial analysis. RESULTS: Questionnaires from 1 554 students (51.0% women) with an average age of 20.5 ± 2.86 years were analyzed. Only 46.7% of the respondents had a good level of knowledge and 37.7% had appropriate attitudes toward research. The variables that correlated with a good leve...