El propósito de estudio del presente trabajo fue evaluar la capacidad diagnóstica de diferentes propuestas de diagnóstico para identificar anemia ferropénica en mujeres gestantes de Cusco. Métodos utilizados para el análisis secundario con base de un estudio observacional de corte transversal, y analítico. Se determinó parámetros laboratoriales de muestras sanguíneas mediante el hemograma automatizado para obtener valores de hemoglobina e índices eritrocitarios. Se usó kits de ELISA para determinar valores de los biomarcadores del estado de hierro. El análisis descriptivo y bivariado fue realizado con el programa Stata, y la capacidad diagnostica evaluada mediante modelos crudos y ajustados en términos de curvas ROC con el programa R v3.6.1. Resultados: La prevalencia de anemia fue diferente según cinco propuestas diagnosticas usando hemoglobina sin corregir fue 2%, correg...

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Background: Medullary aplasia is a disease characterized by pancytopenia with hypocellular bone marrow. Most of these are acquired and can be idiopathic or secondary to bone marrow damage produced by physical, chemical or infectious agents. HTLV-1 is an intracellular retrovirus that is transmitted by prolonged breastfeeding, sexual intercourse, and blood transfusions. Case description: We report the case of a 28-year-old woman who presented petechiae, gingivorrhagia, and generalized paleness. In the laboratory examination, severe pancytopenia was found, HTLV-1 positive, and in the bone marrow aspirate, marked hypocellularity. She received antibiotics, antifungals, antivirals, and immunosuppressive agents with a steady course. Conclusions: HTLV-1 infection is common in Peru; however, its association with medullary aplasia is poorly described. Hematopoietic stem-cell transplantation is an ...

El reordenamiento genético es la combinación de segmentos de genes que se produce por la cofluencia de algunos virus de la misma especie o virus, altera la infecciosidad y el grado de patogenicidad del virus.

El reordenamiento genético es la combinación de segmentos de genes que se produce por la cofluencia de algunos virus de la misma especie o virus, altera la infecciosidad y el grado de patogenicidad del virus.

Background: Vitamin B12 deficiency is a nutritional problem that can present with neurological and hematological manifestations. There are limited reports on the appearance of involuntary movements when initiating cyanocobalamin treatment. Case report: A 5-month-old infant presented vomiting, paleness, and difficulty holding his head. Among the examinations, pancytopenia and vitamin B12 deficiency were found in the patient and the mother. Treatment with folic acid and cyanocobalamin was administered; However, on the fourth day of treatment, she presented choreiform movements for which clonazepam was administered. The tomography and the electroencephalogram were normal. At follow-up, the platelet and leukocyte count improved and the movements gradually remitted. Conclusion: Little is reported about the occurrence of involuntary movements when vitamin B12 deficiency is corrected. Follow-up...

Incentivo del Programa Cienciactiva a publicaciones científicas de estudiantes de medicina humana de una universidad pública del Perú

Background. Hepatocellular carcinoma results in most cases from underlying chronic liver disease. The most common causes are the Hepatitis B virus and the Hepatitis C virus in-fections, the alcoholism and the aflatoxin. Mortality statistics of liver cell carcinoma in Peru is limited. Objectives. Update statistics on hepatocellular carcinoma mortality in Peru between the years 2005 and 2016. Methods. Observation-al, descriptive studyand secondary analysis of the Ministry of Health database. Records with the basic cause of death ICD 10: C22, the liver cell carcinoma were reviewed. Mortality was calculated according to the age, the sex and the department in which death was recorded; Also, standardized mortality by age was calculated. Results. 2,170 people were registered as deceased due to hepatocellular carcinoma. The 50.1% were male and the 67.5% older than 60 years. The standardized mort...

Incentivo del Programa Cienciactiva a publicaciones científicas de estudiantes de medicina humana de una universidad pública del Perú

Background. Cervical ectopic pregnancy is the implantation of the embryo in the lining of ​​the endocervical canal lining. It represents less than 1% of all ectopic pregnancies. Case description: We report two patients who come to the emergency room for transvaginal bleeding. The diagnosis of cervical ectopic pregnancy was made by transvaginal ultrasound (7- and 8-weeks' gestation). Treatment was started with methotrexate (28-year-old patient) and methotrexate-folinic acid (35-year-old patient). Due to the increase in human chorionic gonadotropin hormone, it was decided to perform an abdominal hysterectomy (28-year-old patient) and McDonald-type cervical curettage-cerclage (35-year-old patient). There were no complications after surgery in both patients. Conclusions: The treatment of cervical ectopic pregnancy is controversial. The most appropriate therapy should be chosen to preserv...

Objetive: To identify the need to implement Evidence-Based Medicine (EBM) courses in the undergraduate curricula of Peruvian universities. The estudy: Descriptive observational study. The prevalence of teaching the EBM course in the medical schools of Peruvian universities was evaluated, as well as the semester in which it was taught and its obligatoriness. Findings: Of 44 medical schools evaluated, eight (18.2%) included an EBM course in their curricula, of which five(62.5%) corresponded to private universities and in seven(87,5%) the course was mandatory. Conclusions: The teaching of EBM in Peruvian university medical schools is low, potentially leading to less confidence and certainty in clinical decision making.

Congenital cytomegalovirus infection is a cause of neonatal infection that can be asymptomatic; however, its complications are possible in some organs such as the nervous system and the liver. We report a case of a 2-month-old female infant with cytomegalovirus hepatitis characterized by abdominal distention, cholestasis, irritability, and poor breastfeeding. In the tests, liver involvement, periventricular microcalcifications, and sensorineural hearing loss were found. The diagnosis was determined by serum antibodies, confirmed with viral load in blood, urine, and liver tissue. Treatment with ganciclovir, vitamin K, and ursodeoxycholic acid was administered with adequate evolution. Cytomegalovirus hepatitis is a complication that may be associated with the involvement of other organs. Antiviral treatment for liver involvement is still controversial; however, it is recommended in ...