COVID-19's lethality as well as its rapid spread are responsible for the current world crisis; therefore, from the beginning, drugs with antiviral action against this agent were sought. It is impossible, for now, to know which person in a mild state will develop a high viral load or have a predisposition to develop an extreme response from the immune system, but early treatment in mild cases would not only guarantee greater efficacy, but would avoid severe cases. Currently, there are no double blind, randomized clinical trials or meta-analyzes available to make safe decisions; meanwhile, the pandemic is advancing in our country, generating pain and death. In this context, in Peru, scientific societies have expressed the need for the use of antiviral drugs, even with little evidence, based on the probability of success prior to treatment, for their in vi...

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La Tuberculosis (TB) es uno de los problemas de salud pública no resueltos. En 2017, 10.0 millones de personas desarrollaron la enfermedad, y 1.6 millones de personas murieron, constituyéndose en la principal causa de muerte debido a un solo agente infeccioso . En nuestro país tenemos evidencias que el M. tuberculosis nos acompaña desde la época preinca y continúa hasta la actualidad.

La pandemia del VIH/SIDA en sus 35 sñod, ha acompañado ampliamente a la actual generación productiva del mundo. Surgió como una epidemia apocalíptica, ocasionando una enfermedad progresiva que hacía que la persona se haga susceptible a infecciones oportunistas y cánceres que finalmente los conduciría a la muerte.

La inmunización se ha constituido en una de las medidas de salud pública más importantes implementada en la humanidad, luego del agua potable ha demostrado ser una de las intervenciones más eficaces para disminuir la mortalidad y aquellas secuelas provocadas por las enfermedades inmunoprevenibles. Desde su advenimiento hasta la actualidad sus beneficios como vacunas profilácticas son incuestionables.

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Determina la prevalencia de tuberculosis pulmonar (TBP) en pacientes adultos con ≥ 2 horas de admisión al DE. Evalúa la definición de tamizaje de casos “capacidad de entregar una muestra de esputo sin importar la duración de tos”, y el rendimiento diagnóstico (RD) del “cultivo a todas las muestras”. Determina criterios para la generación de algoritmos diagnósticos y de aislamiento en este escenario. Es un estudio transversal de 14 meses. Se obtuvo muestras de esputo para baciloscopía y cultivo. Realiza análisis bivariado y multivariados (AMV) a fin de determinar factores de riesgo para TBP y TB multidrogoresistente (TB MDR). Se elaboraron Modelos de Score Clínicos (MSC) con los criterios que resultaron significativos en los AMV. Se generaron algoritmos diagnósticos utilizando el criterio de sospecha clínica, los resultados de los MSC, baciloscopía, Xpert® MTB/RIF ...

The COVID-19, in the scant six months of its presence, has caused a global health crisis, with greater impact in the poorest countries. Currently, there is a better understanding of the clinic of this disease and its relationship with physiopathological phenomena; however, given the high lethality, the major focus of its management has been oriented towards the hospitalized or critical patient. This information and experience is shared in order to achieve and strengthen better care for people affected by COVID-19 from their first symptoms at home, especially at these times of extensive community transmission, where health services are seriously limited in human and material resources. The aim is to (i) avoid complications beyond those caused by the evolution of the disease itself; (ii) determine the appropriate time for patient referral to the hospital ...

La trombospondina (TSPI) es una glicoproteína trimérica de P.M. 420 KD y 420,000-D (unidades de D-glucosa), proveniente de una familia de proteínas solubles, caracterizadas por poseer lugares de unión que son en número de cinco; estas son: a)Dominio heparin - sulfato proteoglicanos HSPCs; b)Dominio alfa V beta 3 integrin - arginina (Ar.) - glicina (Gly) - aspártico (Asp.) - alanina (Ala.) y con Ca 2+; c)Subdominio Valina (Val.) - treonina (Thr.) - cisteína (Cys.) - glicina (Gly.) - CD36 (receptor) o gp IV con su carboxil terminal; d)Collagen triple hélice unido al procolágeno de la trombospondina (TSPI), como se muestra en el siguiente esquema: ESQUEMA Nro. 1 Otra de las características de esta familia glicoprotéica, es considerada también como proteina moduladora en la regulación de la emigración y proliferación celular, manifestada durante la evolución de la angiogénes...

La trombospondina (TSPI) es una glicoproteína trimérica de P.M. 420 KD y 420,000-D (unidades de D-glucosa), proveniente de una familia de proteínas solubles, caracterizadas por poseer lugares de unión que son en número de cinco; estas son: a)Dominio heparin - sulfato proteoglicanos HSPCs; b)Dominio alfa V beta 3 integrin - arginina (Ar.) - glicina (Gly) - aspártico (Asp.) - alanina (Ala.) y con Ca 2+; c)Subdominio Valina (Val.) - treonina (Thr.) - cisteína (Cys.) - glicina (Gly.) - CD36 (receptor) o gp IV con su carboxil terminal; d)Collagen triple hélice unido al procolágeno de la trombospondina (TSPI), como se muestra en el siguiente esquema: ESQUEMA Nro. 1 Otra de las características de esta familia glicoprotéica, es considerada también como proteina moduladora en la regulación de la emigración y proliferación celular, manifestada durante la evolución de la angiogénes...

The present ínvestigation íncluided: 100 samples, 20 control groups (Universidad NAcional Agraria students), and 80 patients infected with HIVIA1DS; 25 with level 11, 35 with level III, and 20 patients with level /V Average proteinicfractions and salivary percentage were taken: Albumin 45.15%, SALIVARYALBUMIN 15.2%, GAMMAGLOBULIN 7-5.94% (SIGNIFICANCE LEVEL 1.00%).Problem Sample. - In the problem sample we can see a considerable alteration in the serical electropitoretics proteins. Spit: level 11, 22.12% albumin, gammaglobulin 77.64%, level III, albumin 16.35%, gammaglobulin 83.49%. IV 7.71% albumin and 92.37% gammaglobulin. There is a diferrential relationship between normal values of serical gammaglobulin and salivary ones, in HIV/AIDS ínfected patiens and there is an increase of bucal pathologies

The present ínvestigation íncluided: 100 samples, 20 control groups (Universidad NAcional Agraria students), and 80 patients infected with HIVIA1DS; 25 with level 11, 35 with level III, and 20 patients with level /V Average proteinicfractions and salivary percentage were taken: Albumin 45.15%, SALIVARYALBUMIN 15.2%, GAMMAGLOBULIN 7-5.94% (SIGNIFICANCE LEVEL 1.00%).Problem Sample. - In the problem sample we can see a considerable alteration in the serical electropitoretics proteins. Spit: level 11, 22.12% albumin, gammaglobulin 77.64%, level III, albumin 16.35%, gammaglobulin 83.49%. IV 7.71% albumin and 92.37% gammaglobulin. There is a diferrential relationship between normal values of serical gammaglobulin and salivary ones, in HIV/AIDS ínfected patiens and there is an increase of bucal pathologies

Introduction: We present the results of the execution of the TB zero plan, a socio-political approach that is currently being carried out in the jurisdiction of the San Cosme Health Center in La Victoria district. This is an area with a high risk for TB transmission, showing the highest incidence rates of TB in Peru, and where conditions such as informal employment, psycho-social disturbances, poverty, high migration rates, and overcrowding had hampered success of many intervention measures. The TB zero plan has been in practice since March 2009, using an integrative, systemic, and humanistic approach base don social determinants of health and primary healthcare. The plan is carried out by the local Lima City V Health Direction (DISA V, Lima Ciudad) and La Victoria Municipality, with the active participation of persons affected by TB. The plan has 6 components: political impact, clinical...

Introduction: We present the results of the execution of the TB zero plan, a socio-political approach that is currently being carried out in the jurisdiction of the San Cosme Health Center in La Victoria district. This is an area with a high risk for TB transmission, showing the highest incidence rates of TB in Peru, and where conditions such as informal employment, psycho-social disturbances, poverty, high migration rates, and overcrowding had hampered success of many intervention measures. The TB zero plan has been in practice since March 2009, using an integrative, systemic, and humanistic approach base don social determinants of health and primary healthcare. The plan is carried out by the local Lima City V Health Direction (DISA V, Lima Ciudad) and La Victoria Municipality, with the active participation of persons affected by TB. The plan has 6 components: political impact, clinical...

Introduction. Tuberculosis is a public health problem in our country. Affected patients are slow to access health services, among other factors due to the stigma and social discrimination that this disease has in the population. In addition, stigma has an impact on the social and family relationship of affected patients. The objective of the present study was to quantify the stigma in students of the faculty of medicine of a public university. Methods. An observational, descriptive and transversal study was carried out. A previously validated questionnaire was applied to students of the first three years of medical school, in order to quantify the stigma of tuberculosis. Results. The questionnaire was applied to 505 students of the medical school. 39% of the student population showed a moderate and great stigma in front of the people affected by tuberculosis; likewise, 38% showed a sligh...

Vibrio cholerae serogrupo NO-O1/NO-O139 (VCNO) es causa infrecuente de gastroenteritis. Sin embargo, se le asocia a infección extra-intestinal severa en huéspedes inmunocomprometidos, y entre ellas, la bacteremia en pacientes con cirrosis hepática es digna de mención. A continuación, presentamos el caso de una mujer de 58 años, con el diagnóstico de cirrosis hepática de fondo, que desarrolló progresivamente choque séptico, disfunción orgánica múltiple y desenlace fatal al cuarto día de su admisión. Los resultados obtenidos post mortem, de los hemocultivos previamente tomados, aislaron bacilos gram negativos compatibles con Vibrio cholerae. Posteriormente, se identificó el serogrupo NO-O1/NO-O139, a través de aglutinación en placa y PCR negativo para el gen ctxA. El antibiograma mostró susceptibilidad conservada a ampicilina, cloranfenicol, tetraciclina y ciprofloxacino...

Righty nine samples were analyzed. As control group 25 students aged 20 to 25 years old from the School of Dentistry were selected. We olso studied 44 patients with HIV-AIDS and tuberculosis, 24 patients only with HIV-AIDS, and 10 subjects aged ears old as control group. The average value of salivary proteasa activity in the control group was 0.067 / 18 horas , and we faund that the highest value and the lowest value were 0.084 and 0.045, respectively. In regards to servan proteasa in the 10 subjects used as control (suject.v without HIV-AIDS and tuberculosis), the highest value of proteasa activity was 0.092, the lowest value of proteasa activity was 0.067, and the avarage value of proteasa activity was 0.078118 horas of enzimic work. Tuberculosis and candidiasis evolved leafily by symbiotic way, and there displaced other opportunistic diseases (Kaposi sarcoma), and eve observed progres...

Se analizaron 89 muestras de las cuales 25 alumnos, de 20 a 25 años de la Facultad de Odontología seleccionados como grupo control. 44 pacientes con HIV/SIDA, TBC, 24 pacientes con HIVISIDA, 10 personas de 24 a 45, años de edad como grupo control. La actividad de la proteasa salival en el control, arrojó como promedio 0.067 (absorvencia), siendo la mayor lectura 0.084, la menor actividad 0.045. En cuanto a la proteasasa sérica en 10 personas (sin HIV/SIDA TBC). arrojó mayor actividad 0.092 y menor actividad 0.067 como promedio 0.078 (,abs.). La tuberculosis y la candidiasis evolucionan frondosamente en forma simbiótica, siendo desplazadas otras enfermedades oportunistas (Sarcoma de Kaposi), observándose disminución progresiva del flujo saliva como constante inhibición del proceso carioso, periodontales (simple gingivitis). En pacientes con HIV/SIDA TBC, la actividad de la prote...