1
artículo
Publicado 2021
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Tropical pyomyositis is characterized by deep suppurative skeletal muscle infection most commonly by Staphylococcal Aureus (S. aureus) with increasing incidence of infection by community acquired methicillin resistant S. aureus(CA-MRSA). The initial clinical presentation is generally non-specific and requires a high index of suspicion. We report the clinical course of a child from subtropical area of North India who developed multiple deep pyogenous collections, complicated with CA-MRSA septicaemia and followed by unusual complications consistent with Guillain-Barré Syndrome.
2
artículo
Publicado 2022
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Nutritious foods are needed for the continuously growing population together with the nutrient for plant growth and production. Inorganic chemical-based fertilizers have been base and are used heavily in today’s soil management procedures, posing serious health and environmental concern. Biofertilizer has been recognized as a reasonable solution for improving soil fertility and crop output in sustainable farming. The use of beneficial microorganisms as biofertilizers has escalated its importance in the agricultural industry due to its potential significance in food safety and sustainable crop production. Biofertilizers can be a valuable component of a comprehensive nutrient management strategy. Overall, nitrogen fixers (N-fixers), potassium and phosphorus solubilizers, growth-promoting rhizobacteria (PGPR), endo and ectomycorrhizal fungi, cyanobacteria, and other beneficial microscopic...
3
artículo
Publicado 2018
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Purpose: Prognostic value of pathologic complete response (pCR) and extent of pathologic response attained with anthracycline-free platinum plus taxane neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) is unknown. We report recurrence-free survival (RFS) and overall survival (OS) according to degree of pathologic response in patients treated with carboplatin plus docetaxel NAC. Patients and methods: One-hundred and ninety patients with stage I-III TNBC were treated with neoadjuvant carboplatin (AUC6) plus docetaxel (75 mg/m2) every 21 days × 6 cycles. pCR (no evidence of invasive tumor in breast and axilla) and Residual cancer burden (RCB) were evaluated. Patients were followed for recurrence and survival. Extent of pathologic response was associated with RFS and OS using the Kaplan-Meier method. Results: Median age was 51 years, and 52% were node-positive. pCR and ...
4
artículo
Publicado 2013
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Proyecto FEMCIDI-OEA SEDI/AE-305 /09 (2008-2012), Proyecto Bilateral Argentina, Per; FINCyT (099-FINCyT-EQUIP-2009) / (076-FINCyT-PIN-2008), Prestamo BID no. 1663/OC-PE, Instituto Nacional de Innovacion Agraria, Ministry of Agriculture of Peru, Peruvian Ministry of Agriculture, Technical Secretariat of coordination with the CGIAR, Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica, Peru (CONCYTEC), Special Multilateral Fund of the Inter-American Council for Integral Development (FEMCIDI-Peru).
5
artículo
Publicado 2022
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Global competition extends several challenges to micro, small and medium enterprises (MSMEs) organisations. There is an increasing need for these firms to adopt strategies for productivity improvement. Six Sigma is a data driven methodology supported by statistical, mathematical and managerial techniques for improving the bottom line effectively. In this paper, an application of DMAIRC model of Six Sigma is presented in context to a quality improvement initiative in an MSME organisation. DMAIRC is an effective alternative to linear DMAIC model, as it provides opportunity to review results and diagnose additional improvements. The additional improvements are checked for feasibility and implemented through additional improvement cycles. The study also demonstrates integration of the quality management techniques such as Pareto analysis, cause and effect analysis, current reality tree, desi...
6
artículo
Publicado 2023
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Weeds are the major burden for rice-growing farmers in the case of direct-seeded rice due to the preemptive competition of weed in the species early seedling stage. A field experiment was carried out during the spring season in 2021 to evaluate the effect of different weed management practices and row spacing on dry directed-seeded spring rice under the Prime Minister Agriculture Modernization Project (PMAMP) at Rice Super Zone, Kanchanpur, Nepal. The experiment was laid out in a two-factorial randomized complete block design (RCBD) with twelve treatments and three replications. The highest number of effective tillers per m2 was obtained in weed-free plots (531.67), which is statistically similar to Pretilachlor fb 1HW (505.42). Row spacing of 10 cm showed a significantly higher number of effective tillers per square meter (521.94). A higher grain yield was observed in weed-free plots (6...
7
tesis de maestría
Publicado 2025
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La presente pesquisa se enmarca en los objetivos de desarrollo sostenible 16 y 5, referidos a la Paz, Justicia e Instituciones Sólidas, y a la Igualdad de Género, respectivamente. Tuvo como objetivo analizar por qué existe impunidad de delitos de agresión psicológica en víctimas de violencia familiar en un distrito fiscal de Lima, 2024. El estudio empleó una metodología cualitativa con diseño fenomenológicohermenéutico, realizando entrevistas a profundidad a siete profesionales del sistema de justicia, incluyendo fiscales, defensores públicos y abogados especializados. Los resultados revelaron que la impunidad se origina por una compleja interacción de factores, destacando las limitaciones probatorias en la acreditación del daño psicológico, las deficiencias institucionales por falta de recursos y personal especializado, y las barreras procesales manifestadas en los exten...
8
artículo
Publicado 2020
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Purpose: Among the many factors fueling the inflationary tendencies in an economy such as monetary shocks, structural shocks, demand shocks, external shocks and demographic changes, the issue of inflation (INF) has also been found to be related to fiscal policy decisions of the government. The purpose of this study is to investigate the inflationary tendencies in India particularly from the fiscal point of view. The study also examines the influence of other potential determinants such as output growth rate, interest rate, tradeopenness (TO) and oil price inflation (OPI). Design/methodology/approach: To examine the dynamic nature of association between fiscal deficit and inflation, the study applies the Toda-Yamamoto (1995) test and Breitung and Candelon (2006) test to investigate the nature of causality in time and frequency domain frameworks. In addition, to scrutinize the possibility ...
9
artículo
Publicado 2020
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Purpose: Among the many factors fueling the inflationary tendencies in an economy such as monetary shocks, structural shocks, demand shocks, external shocks and demographic changes, the issue of inflation (INF) has also been found to be related to fiscal policy decisions of the government. The purpose of this study is to investigate the inflationary tendencies in India particularly from the fiscal point of view. The study also examines the influence of other potential determinants such as output growth rate, interest rate, tradeopenness (TO) and oil price inflation (OPI). Design/methodology/approach: To examine the dynamic nature of association between fiscal deficit and inflation, the study applies the Toda-Yamamoto (1995) test and Breitung and Candelon (2006) test to investigate the nature of causality in time and frequency domain frameworks. In addition, to scrutinize the possibilit...
10
artículo
Publicado 2021
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The following paper will reveal the varieties of English pronunciation in India, its features and characteristics. This research helped us to consider the history of occurrence of English in India, the influence of local languages on it, the birth of its own unique English, which is used in India now. The research highlights the impact of English on Indians in general and its modification as the individual language differs from other English variants. The paper illustrates the features of translation and vocabulary in Indian English, which will explore the specification uses of it. The research also provides variations of Indian English as dialect and pronunciation in India because it changes from north to south and east to west. To complete our study, we used a lot of methods, such as observation, comparative, elicitation approaches, collection and analysis of diverse information. Such ...
11
artículo
Publicado 2021
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The following paper will reveal the varieties of English pronunciation in India, its features and characteristics. This research helped us to consider the history of occurrence of English in India, the influence of local languages on it, the birth of its own unique English, which is used in India now. The research highlights the impact of English on Indians in general and its modification as the individual language differs from other English variants. The paper illustrates the features of translation and vocabulary in Indian English, which will explore the specification uses of it. The research also provides variations of Indian English as dialect and pronunciation in India because it changes from north to south and east to west. To complete our study, we used a lot of methods, such as observation, comparative, elicitation approaches, collection and analysis of diverse information. Such ...
12
artículo
Publicado 2022
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Cloud computing is about delivery of different computing services involving databases, analytics, software, networking with the use of internet to enhance innovation, incorporate flexibility in resources and broaden profitability. However, Internet of Things (IoT) is an essential system for interrelating computer devices, digital machines, people and others which are offered with unique identifiers where data can be transferred with human involvement and wireless network. 42% of organisations in UK use cloud computing. The problem with cloud computing revolves around security and privacy issues as data is stored by a third party from inside or outside of the organisation leading to broken authentication, compromising of credentials and others. The use of IoT is vulnerable as it provides connectivity to devices, machines and people therefore, it needs to contain more storage that is made ...
13
artículo
Publicado 2025
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Introduction: Adenoma detection rate (ADR) and sessile serrated lesion (SSL) detection rate (SDR) are crucial quality indicators for colonoscopy, as their improvement contributes to effective prevention of colorectal cancer. Artificial intelligence (AI) has been shown to significantly increase ADR. This study compared white light imaging (WLI) versus AI-assisted WLI for neoplasia detection. Materials and methods: This was a prospective, randomised trial of screening, surveillance, and symptomatic patients. Our primary objective was to evaluate ADR. Secondary objectives included SDR, mean number of adenomas per patient (MAP), neoplasia detection rate (NDR), advanced ADR (AADR), and colonoscope withdrawal time. Results: A total of 621 adenomas were diagnosed in 711 patients, with 310 adenomas in the WLI group and 311 adenomas in the WLI+AI group (p=0.65). Eighty-three SSLs and two intramuc...
14
artículo
Publicado 2025
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Multiple sclerosis (MS) is a chronic autoimmune condition causing damage to the protective covering of nerves in the central nervous system. Pediatric multiple sclerosis is a rare form of the disease that affects 3-5% of individuals with multiple sclerosis. Pediatric Onset Multiple Sclerosis (POMS) has a rather different clinical profile from the more prevalent adult multiple sclerosis. Alongside the classic symptoms of multiple sclerosis, children tend to present with various atypical symptoms that can impact motor milestones, speech development, and cognitive functions. This review aims to explore the pathogenesis, clinical features, diagnosis and progression of Pediatric Onset Multiple Sclerosis into adulthood, address the challenges accompanying this transition and identify strategies and therapies to overcome them. Pediatric multiple sclerosis patients transitioning into adulthood f...
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artículo
Background: To emphasize treatment speed for time-sensitive conditions, emergency medicine has developed not only the concept of the golden hour, but also the platinum half-hour. Patients with acute stroke treated within the first half-hour of onset have not been previously characterized. Methods: In this cohort study, we analyzed patients enrolled in the FAST-MAG (Field Administration of Stroke Therapy-Magnesium) trial, testing paramedic prehospital start of neuroprotective agent ≤2 hours of onset. The features of all acute cerebral ischemia, and intracranial hemorrhage patients with treatment starting at ≤30 m of last known well were compared with later-treated patients. Results: Among 1680 patients, 203 (12.1%) received study agents within 30 minutes of last known well. Among platinum half-hour patients, median onset-to-treatment time was 28 minutes (interquartile range, 25-30), a...
16
artículo
Publicado 2022
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Importance: Most of the global morbidity and mortality in chronic obstructive pulmonary disease (COPD) occurs in low- and middle-income countries (LMICs), with significant economic effects. Objective: To assess the discriminative accuracy of 3 instruments using questionnaires and peak expiratory flow (PEF) to screen for COPD in 3 LMIC settings. Design, Setting, and Participants: A cross-sectional analysis of discriminative accuracy, conducted between January 2018 and March 2020 in semiurban Bhaktapur, Nepal; urban Lima, Peru; and rural Nakaseke, Uganda, using a random age- and sex-stratified sample of the population 40 years or older. Exposures: Three screening tools, the COPD Assessment in Primary Care to Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE; range, 0-6; high risk indicated by a score of 5 or more or score 2-5 with low PEF [<250 L/min for females and <...
17
artículo
Publicado 2024
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Background: Identification of biomarkers to optimize treatment strategies for early-stage triple-negative breast cancer (TNBC) is crucial. This study presents the development and validation of TNBC-DX, a novel test aimed at predicting both short- and long-term outcomes in early-stage TNBC. The objective of this study was to evaluate the association between TNBC-DX and efficacy outcomes [pathologic complete response (pCR), distant disease-free survival (DDFS) or event-free survival (EFS), and overall survival (OS)] in the validation cohorts. Methods: Information from 1259 patients with early-stage TNBC (SCAN-B, CALGB-40603, and BrighTNess) was used to establish the TNBC-DX scores. Independent validation of TNBC-DX was carried out in three studies: (i) WSG-ADAPT-TN; (ii) MMJ-CAR-2014-01; and (iii) NeoPACT, including 527 patients with stage I-III TNBC undergoing neoadjuvant chemotherapy. In...
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artículo
BACKGROUND: These clinical standards aim to provide guidance for diagnosis, treatment, and management of drug-susceptible TB in children and adolescents. METHODS: Fifty-two global experts in paediatric TB participated in a Delphi consensus process. After eight rounds of revisions, 51/52 (98%) participants endorsed the final document. RESULTS: Eight standards were identified: Standard 1, Age and developmental stage are critical considerations in the assessment and management of TB; Standard 2, Children and adolescents with symptoms and signs of TB disease should undergo prompt evaluation, and diagnosis and treatment initiation should not depend on microbiological confirmation; Standard 3, Treatment initiation is particularly urgent in children and adolescents with presumptive TB meningitis and disseminated (miliary) TB; Standard 4, Children and adolescents should be treated with an approp...
19
artículo
Publicado 2025
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In spite of the growing interest in the microbiome in human cancer, there are currently only small-scale lung cancer microbiome studies conducted directly on tissue. As part of the Sherlock-Lung study, we studied the microbiomes of 940 lung cancers (4,090 samples) in never smokers (LCINS) directly from lung tissue using three data types: 16S rRNA gene sequencing (16S), whole-genome sequencing (WGS) with paired blood, and RNA-seq. We observe very low biomass and few microbiome associations in LCINS using 16S and WGS tissue. Using RNA-seq, we observe more total microbial reads, and decreased relative abundance of several commensal bacteria at the genus and species levels in tumors relative to paired normal lung tissue. Among all datasets, we see no consistent associations between the lung tissue microbiome, or circulating bacterial DNA, and any available demographic and clinical features, ...
20
artículo
Publicado 2023
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As the adverse impacts of hydrological extremes increase in many regions of the world, a better understanding of the drivers of changes in risk and impacts is essential for effective flood and drought risk management and climate adaptation. However, there is currently a lack of comprehensive, empirical data about the processes, interactions, and feedbacks in complex human–water systems leading to flood and drought impacts. Here we present a benchmark dataset containing socio-hydrological data of paired events, i.e. two floods or two droughts that occurred in the same area. The 45 paired events occurred in 42 different study areas and cover a wide range of socio-economic and hydro-climatic conditions. The dataset is unique in covering both floods and droughts, in the number of cases assessed and in the quantity of socio-hydrological data. The benchmark dataset comprises (1) detailed rev...
