1
artículo
Publicado 2018
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Objective: To report if there are hematologic and biochemical differences among patients with and without type 2 diabetes mellitus (T2DM) undergoing hemodialysis (HD). Materials and methods: An observational, retrospective, cohort study of patients treated in the Renal Health Program at the Centro de Prevención de Enfermedad Renal S.A.C. (CENPER) in Lima, Peru. The hematologic and biochemical parameters of 3 patients with T2DM and 3 patients without T2DM undergoing HD were compared. Results: Significant differences (p < 0.05) were found in the lymphocyte percentage, lymphocyte/monocyte ratio (LMR), hemoglobin and hematocrit concentration (lower in diabetic patients), monocyte percentage, and neutrophil/ lymphocyte ratio (NLR) (higher in diabetic patients). In the biochemical parameters, the only significant difference was found in the glutamic-oxaloacetic transaminase (GOT) value,...
2
artículo
Publicado 2006
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This paper aims to develop the thermal process integration and PINCH applying technology to the production of ethanol from sweet potato variety INIA 306 Huambachero. The first part is presented, process technology, which consisted of a first tase hydrolysis of starch. a brewing malt enzymes obtained in a maximum time of 20 minutes, followed by fermentation with yeast saccharomyces cerevisiae. providing a yield of 85 to 95 liters of ethanol per ton of sweet potato and representing about economic benefit of up to 25% reduction in production costs of ethanol per liter compared with conventional alcohol as raw sugar cane molasses.
3
artículo
Publicado 2006
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This paper aims to develop the thermal process integration and PINCH applying technology to the production of ethanol from sweet potato variety INIA 306 Huambachero. The first part is presented, process technology, which consisted of a first tase hydrolysis of starch. a brewing malt enzymes obtained in a maximum time of 20 minutes, followed by fermentation with yeast saccharomyces cerevisiae. providing a yield of 85 to 95 liters of ethanol per ton of sweet potato and representing about economic benefit of up to 25% reduction in production costs of ethanol per liter compared with conventional alcohol as raw sugar cane molasses.
4
artículo
Publicado 2008
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The goal of this research work is the design of a cleaner process for the production of fuel ethanol sweet potato. Applying the principles of conceptual design, Pinch analysis and the use of simulators chem cad and pinch cad, it is determined that the process with molecular sieves is the most effective to get ethanol from 99.5% purity with a power demand of 1400 Kj/kg of ethanol. We conclude that these results impacting positively on the economy of Peru by establishing a path of sustainable development both technically, economically, socially and environmentally.
5
artículo
Publicado 2008
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The goal of this research work is the design of a cleaner process for the production of fuel ethanol sweet potato. Applying the principles of conceptual design, Pinch analysis and the use of simulators chem cad and pinch cad, it is determined that the process with molecular sieves is the most effective to get ethanol from 99.5% purity with a power demand of 1400 Kj/kg of ethanol. We conclude that these results impacting positively on the economy of Peru by establishing a path of sustainable development both technically, economically, socially and environmentally.
6
artículo
Publicado 2013
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Objectives: Data on chemotherapy regimens in elderly patients with metastatic breast cancer (MBC) are limited. The aim of this retrospective pooled analysis was to determine efficacy and safety of ixabepilone plus capecitabine versus capecitabine alone in patients with MBC aged ≥ 65 years. Materials and methods: A total of 1973 patients with MBC previously treated with or resistant to anthracyclines and taxanes were randomized in two open-label, multinational, phase 3 studies (study 046 and study 048). Patients received ixabepilone (40 mg/m(2) as a 3-hour intravenous infusion every 3 weeks) plus oral capecitabine (1000 mg/m(2) administered twice each day), or capecitabine alone (1250 mg/m(2) twice each day). Results: In total, 251 randomized patients were aged ≥ 65 years (ixabepilone plus capecitabine, n=116; capecitabine monotherapy, n=135). Efficacy results were consistent in patie...
7
artículo
Publicado 2020
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Basal-like breast cancer (BLBC) is an aggressive disease that lacks a clinically approved targeted therapy. Traditional chemotherapy is effective in BLBC, but it spares the cancer stem cell (CSC)-like population, which is likely to contribute to cancer recurrence after the initial treatment. Dual specificity phosphatase-4 (DUSP4) is a negative regulator of the mitogen-activated protein kinase (MAPK) pathway that is deficient in highly aggressive BLBCs treated with chemotherapy, leading to aberrant MAPK activation and resistance to taxane-induced apoptosis. Herein, we investigated how DUSP4 regulates the MAP-ERK kinase (MEK) and c-jun-NH2-kinase (JNK) pathways in modifying CSC-like behavior. DUSP4 loss increased mammosphere formation and the expression of the CSC-promoting cytokines interleukin (IL)-6 and IL-8. These effects were caused in part by loss of control of the MEK and JNK pathwa...
8
artículo
Introducción: El conocimiento de la Ley de Seguridad de Salud en el Trabajo debe ser un deber y un derecho de los trabajadores, para exigir su cumplimiento y poder proteger a los trabajadores de los riesgos ocupacionales. Objetivo: El objetivo fue determinar el nivel de conocimiento de salud ocupacional en trabajadores de dos hospitales de Lima. Métodos: Estudio transversal analítico, se encuestó al personal de salud laborando en el Hospital Nacional De Emergencias José Casimiro Ulloa y en el Hospital Municipal de Los Olivos. Se les consideró con buen nivel de conocimiento a aquellos cuyas respuestas correctas superaran el 50%, además de variables socio-laborales. Se obtuvieron las razones de prevalencias crudas (RPc) y ajustadas (RPa) de las variables socio-educativas según haber aprobado. Resultados: De los 207 encuestados, el 52,9% (109) tuvo un inadecuado nivel de conocimient...
9
artículo
Publicado 2020
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Background: The aim of this study was to determine the utility of the neutrophil-to-lymphocyte ratio (NLR) as a biomarker for predicting early-mortality (<2 years) among females with metastatic triple-negative breast cancer (mTNBC). Methods: We reviewed 118 medical records of females with mTNBC. The cut-off value for the NLR (<2.5 and ≥2.5) was determined with receiver operating characteristic curves (area under the curve: 0.73; 95% CI: 0.62-0.85). Survival curves were estimated using the Kaplan-Meier method and compared with the Log-rank test. Multivariate Cox regression was used to identify the risk of mortality at two years. Moreover, we performed sensitivity analyses with different cut-off values and a subgroup analysis in females that only received chemotherapy. Results: The median follow-up was 24 months. Females with NLR ≥2.5 had a poor overall survival compared to females wit...
10
artículo
Publicado 2023
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Purpose: Predictive biomarkers for capecitabine benefit in triple-negative breast cancer (TNBC) have been recently proposed using samples from phase III clinical trials, including non-basal phenotype and biomarkers related to angiogenesis, stroma, and capecitabine activation genes. We aimed to validate these findings on the larger phase III GEICAM/CIBOMA clinical trial. Experimental Design: Tumor tissues from patients with TNBC randomized to standard (neo)adjuvant chemotherapy followed by capecitabine versus observation were analyzed using a 164-gene NanoString custom nCounter codeset measuring mRNA expression. A prespecified statistical plan sought to verify the predictive capacity of PAM50 non-basal molecular subtype and tested the hypotheses that breast tumors with increased expression of (meta) genes for cytotoxic cells, mast cells, endothelial cells, PDL2, and 38 individual genes be...
11
artículo
Publicado 2019
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Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the ...
12
objeto de conferencia
Publicado 2023
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Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The combined analysis of SOFT-TEXT compared outcomes in 4,690 premenopausal women with estrogen/progesterone receptor-positive (ER/PgR+) early breast cancer randomly assigned to 5 years of exemestane + ovarian function suppression (OFS) versus tamoxifen + OFS. After a median follow-up of 9 years, exemestane + OFS significantly improved disease-free survival (DFS) and distant recurrence-free interval (DRFI), but not overall survival, compared with tamoxifen + OFS. We now rep...
