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artículo

Pathological Response in a Triple-Negative Breast Cancer Cohort Treated with Neoadjuvant Carboplatin and Docetaxel According to Lehmann's Refined Classification

Publicado por
Echavarria, I, López-Tarruella, S, Picornell, A, García-Saenz, JÁ, Jerez, Y, Hoadley, K, Gomez, HL, Moreno, F, Monte-Millan, MD, Márquez-Rodas, I, Alvarez, E, Ramos-Medina, R, Gayarre, J, Massarrah, T, Ocaña, I, Cebollero, M, Fuentes, H, Barnadas, A, Ballesteros, AI, Bohn, U, Perou, CM, Martin, M

Publicado 2018

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Purpose: Triple-negative breast cancer (TNBC) requires the iden- tification of reliable predictors of response to neoadjuvant chemotherapy (NACT). For this purpose, we aimed to evaluate the performance of the TNBCtype-4 classifier in a cohort of patients with TNBC treated with neoadjuvant carboplatin and docetaxel (TCb).Methods: Patients with TNBC were accrued in a nonrandomized trial of neoadjuvant carboplatin AUC 6 and docetaxel 75 mg/m2 for six cycles. Response was evaluated in terms of pathologic complete response (pCR, ypT0/is ypN0) and residual cancer burden by Symmans and colleagues. Lehmann's subtyping was performed using the TNBCtype online tool from RNAseq data, and germline sequencing of a panel of seven DNA damage repair genes was conducted.Results: Ninety-four out of the 121 patients enrolled in the trial had RNAseq available. The overall pCR rate was 44.7%. Lehmann sub...

artículo

TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy

Publicado por
Martín, M, Stecklein, SR, Gluz, O, Villacampa, G, Monte-Millán, M, Nitz, U, Cobo, S, Christgen, M, Brasó-Maristany, F, Álvarez, EL, Echavarría, I, Conte, B, Kuemmel, S, Bueno-Muiño, C, Jerez, Y, Kates, R, Cebollero, M, Kolberg-Liedtke, C, Bueno, O, García-Saenz, JÁ, Moreno, F, Grischke, E-M, Forstbauer, H, Braun, M, Warm, M, Hackmann, J, Uleer, C, Aktas, B, Schumacher, C, Wuerstleins, R, Graeser, M, zu, Eulenburg, C, Kreipe, HH, Gómez, H, Massarrah, T, Herrero, B, Paré, L, Bohn, U, López-Tarruella, S, Vivancos, A, Sanfeliu, E, Parker, JS, Perou, CM, Villagrasa, P, Prat, A, Sharma, P, Harbeck, N

Publicado 2024

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Background: Identification of biomarkers to optimize treatment strategies for early-stage triple-negative breast cancer (TNBC) is crucial. This study presents the development and validation of TNBC-DX, a novel test aimed at predicting both short- and long-term outcomes in early-stage TNBC. The objective of this study was to evaluate the association between TNBC-DX and efficacy outcomes [pathologic complete response (pCR), distant disease-free survival (DDFS) or event-free survival (EFS), and overall survival (OS)] in the validation cohorts. Methods: Information from 1259 patients with early-stage TNBC (SCAN-B, CALGB-40603, and BrighTNess) was used to establish the TNBC-DX scores. Independent validation of TNBC-DX was carried out in three studies: (i) WSG-ADAPT-TN; (ii) MMJ-CAR-2014-01; and (iii) NeoPACT, including 527 patients with stage I-III TNBC undergoing neoadjuvant chemotherapy. In...