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artículo

Microbiome analysis of 940 lung cancers in neversmokers reveals lack of clinically relevant associations

Publicado por
McElderry, John P., Zhang, Tongwu, Zhao, Wei, Hoang, Phuc H., Samuel , Anyaso-Samuel, Sang, Jian, Khandekar, Azhar, Hartman, Caleb, Colón-Mato, Frank J., Miraftab, Mona, Saha, Monjoy, Lee, Olivia, Sharma, Sunandini, Jones, Kristine M., Zhu, Bin, Díaz-Gay, Marcos, Mas, Luis, Arrieta Rodriguez, Oscar Gerardo, Edell, Eric S., Martínez Santamaría, Jacobo, Schabath, Matthew B., Yendamur, Sai, Manczuk, Marta, Lissowska, Jolanta, Świątkowska, Beata, Mukeria, Anush, Shangina, Oxana, Zaridze, David, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Ognjanovic, Simona, Savic, Milan, Kontic, Milica, Bossé, Yohan, Gould Rothberg, Bonnie E., Christiani, David C., Gaborieau, Valerie, Brennan, Paul, Liu, Geoffrey, Hofman, Paul, Pik Wong, Maria, Chung Leung, Kin, Chen, Chih-Yi, Hsiung, Chao Agnes, Rothman, Nathaniel, Leduc, Charles, Baine, Marina K., Travis, William D., Sholl, Lynette M., Joubert, Philippe, Homer, Robert, Yang, Soo-Ryum, Lan, Qing, Nowak, Martin A., Wedge, David C., Alexandrov, Ludmil B., Chanock, Stephen J., Vogtmann, Emily, Abnet, Christian C., Shi, Jianxin, Landi, Maria Teresa

Publicado 2025

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In spite of the growing interest in the microbiome in human cancer, there are currently only small-scale lung cancer microbiome studies conducted directly on tissue. As part of the Sherlock-Lung study, we studied the microbiomes of 940 lung cancers (4,090 samples) in never smokers (LCINS) directly from lung tissue using three data types: 16S rRNA gene sequencing (16S), whole-genome sequencing (WGS) with paired blood, and RNA-seq. We observe very low biomass and few microbiome associations in LCINS using 16S and WGS tissue. Using RNA-seq, we observe more total microbial reads, and decreased relative abundance of several commensal bacteria at the genus and species levels in tumors relative to paired normal lung tissue. Among all datasets, we see no consistent associations between the lung tissue microbiome, or circulating bacterial DNA, and any available demographic and clinical features, ...