Objective: To predict by using bioinformatic tools Mycobacterium tuberculosis (MT) metabolic pathways under hypoxic conditions. Design: Biology analysis. Setting: Instituto de Química Biológica, Microbiología y Biotecnología Marco Antonio Garrido Malo Biological, Microbiologic and Biotechnologic Chemistry Institute, Faculty of Pharmacy and Biochemistry, UNMSM. Biologic material: Mycobacterium tuberculosis genes. Methods: The study began with the selection of 355 genes of MT H37Rv whose expression has been shown by other studies is induced by hypoxic conditions and 359 genes whose expression was repressed. Up and down expressed genes were comparatively analyzed, localizing genes of each group within the MT genome and predicting some physicochemical properties (isoelectric point and hydrophobic moment) for their protein products. In order to assign a metabolic or regulatory pathway to ...

In the present study were evaluated the bioactive compounds and antioxidant activity and satisfaction degree of a drink made with purple corn and stevia. Were used HPLC, ABTS, ORAC, DPPH methods and was done comparison according to the hedonic scale. Results showed close phenolic compounds to 2 mg/mL, high in anthocyanins (50,84 mg/100 mL) and antioxidant activity with ABTS (TEAC 17,96 pmol/mL), ORAC (31,01 μmol TEAC/mL) and DPPH (GAE 0,706 mg/mL). The useful life assessment revealed a synergistic effect between the purple corn anthocyanins and the active components of stevia. The satisfaction degree revealed that the formulation was described between "really like " (19%) and "like slightly " (33%) according to the hedonic scale about attributes of color, smell, taste and overall acceptability.

En la presente investigación se evaluaron los compuestos bioactivos, y se determinaron la actividad antioxidante y el grado de satisfacción de una bebida de maíz morado y estevia, mediante los métodos por HPLC, ABTS, ORAC, DPPH y por comparación según la escala hedónica. Los resultados mostraron compuestos fenólicos cercanos a 2 mg/mL, altos contenidos de antocianinas (50,84 mg/100 mL) y actividad antioxidante según ABTS (17,96 μmol TEAC/mL), ORAC (31,01 μmol TEAC/mL) y DPPH (0,706 GAE mg/mL). La evaluación de vida útil reveló un efecto sinérgico entre las antocianinas del maíz morado y los componentes activos de la estevia. El grado de satisfacción reveló que el formulado se califica entre “me gusta mucho” (19%) y “me gusta ligeramente” (33%) según escala hedónica sobre los atributos de color, olor, sabor y aceptabilidad en general.

To study extracts of the cotton biocides it has collected more than thirty species of plants, which were classified taxonomically in the Natural History Museum of the Universidad Nacional Mayor de San Marcos, between species that are considered relevant for its insecticidal properties we have the following species: Tephrosia cinerea (sacha barbasco), Artemisia absinthium (wormwood), Ryania speciosa (riania), Cissampelos grandifolia (legia), Datura stramonium (chamico), Hura crepitans (catahua), Schinus molle (molle), Annona cherimola (chirimoya), Annona muricata (guanabana or graviola), Tagetes patula (Marigold), Tanacetum parthenium (santa maria), Chromolaena laevigata (sacha huaca), Clibadium asperum (huaca), Lonchocarpus nicou (Mount mullein), Lonchocarpus spiciflorus (yumanasa), Centropogon cornutus (arco sacha), Erythrina berteroana (small amasisa), Erythrina edulis (pajuro), Erythr...

To study extracts of the cotton biocides it has collected more than thirty species of plants, which were classified taxonomically in the Natural History Museum of the Universidad Nacional Mayor de San Marcos, between species that are considered relevant for its insecticidal properties we have the following species: Tephrosia cinerea (sacha barbasco), Artemisia absinthium (wormwood), Ryania speciosa (riania), Cissampelos grandifolia (legia), Datura stramonium (chamico), Hura crepitans (catahua), Schinus molle (molle), Annona cherimola (chirimoya), Annona muricata (guanabana or graviola), Tagetes patula (Marigold), Tanacetum parthenium (santa maria), Chromolaena laevigata (sacha huaca), Clibadium asperum (huaca), Lonchocarpus nicou (Mount mullein), Lonchocarpus spiciflorus (yumanasa), Centropogon cornutus (arco sacha), Erythrina berteroana (small amasisa), Erythrina edulis (pajuro), Erythr...

The present study was conducted to evaluate the hypoglycemic effect of Smallanthus sonchifolius (yacon) leaves, in the form of infusion (aqueous extract) administered to patients with type 2 diabetes mellitus. After signing informed consent, were included 206 people aged 30 to 70 years old, male and female: 105 diagnosed with type 2 diabetes mellitus and 101 apparently healthy control group. Type 2 diabetic patients were people who go to Scholar Healthcare of Clinical Analysis (SAAAC), Office of Pharmaceutical Care (GAF) of the Faculty of Pharmacy and Biochemistry, Club of type 2 diabetic patients of Cayetano Heredia Hospital and Patrucco Raul Puig Health Center (CERIT). From type 2 diabetic patients receiving drug treatment, there were 46 metabolically controlled patients and 59 not metabolically controlled ones. The latter group was given filter bags of yacon leaves of 1 g each, to be ...

The present study was conducted to evaluate the hypoglycemic effect of Smallanthus sonchifolius (yacon) leaves, in the form of infusion (aqueous extract) administered to patients with type 2 diabetes mellitus. After signing informed consent, were included 206 people aged 30 to 70 years old, male and female: 105 diagnosed with type 2 diabetes mellitus and 101 apparently healthy control group. Type 2 diabetic patients were people who go to Scholar Healthcare of Clinical Analysis (SAAAC), Office of Pharmaceutical Care (GAF) of the Faculty of Pharmacy and Biochemistry, Club of type 2 diabetic patients of Cayetano Heredia Hospital and Patrucco Raul Puig Health Center (CERIT). From type 2 diabetic patients receiving drug treatment, there were 46 metabolically controlled patients and 59 not metabolically controlled ones. The latter group was given filter bags of yacon leaves of 1 g each, to be ...

Introduction: Pharmacogenetics can be used in clinical analysis to assess the efficiency of drugs according to the patient’s genetic profile, and it is becoming important for population genetics and precision medicine. The type 2 diabetes mellitus (T2DM) is highly prevalent all over the world, including Peru. Among the different drugs for T2DM, metformin is used the most and patient’s response to it can be influenced by the Val/Met polymorphism of the OCT1 (SLC22) gene, where Met is associated with a lower response. The frequencies of these polymorphisms vary according to ethnic origin. Objective: To evaluate the distribution of the Val/Met polymorphism in the OCT1 gene in samples of Lima and Puno, and to assess their impact on pharmacogenetics of T2DM. Design: Descriptive, cross-sectional study. Settings: Faculties of Pharmacy and Biochemistry, and Medicine, Universidad Nacional May...