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artículo

Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries

Publicado por
Nishath, T, Li, X, Chandramohan, A, Othus, M, Ji, X, Zou, Y, Sultana, S, Rashid, R, Sherief, ST, Cassoux, N, Leon, JLG, Coronado, RD, Lopez, AMZ, Ushakova, TL, Polyakov, VG, Roy, SR, Ahmad, A, Reddy, A, Sagoo, MS, Harby, LA, Kim, JW, Berry, JL, Polski, A, Astbury, N, Bascaran, C, Blum, S, Bowman, R, Burton, MJ, Foster, A, Gomel, N, Keren-Froim, N, Madgar, S, Zondervan, M, Kaliki, S, Fabian, ID, Stacey, A

Publicado 2023

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Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients. Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment. Results Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher r...

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artículo

The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study

Publicado por
Lloyd, P, Westcott, M, Kaliki, S, Ji, X, Zou, Y, Rashid, R, Sultana, S, Sherief, ST, Cassoux, N, Diaz-Coronado, RY, Garcia-Leon, JL, Lopez, AMZ, Polyakov, VG, Ushakova, TL, Roy, SR, Ahmad, A, Harby, LA, Berry, JL, Kim, J, Polski, A, Astbury, NJ, Bascaran, C, Blum, S, Bowman, R, Burton, MJ, Foster, A, Gomel, N, Keren-Froim, N, Madgar, S, Stacey, AW, Mohamed, A, Zondervan, M, Sagoo, MS, Fabian, ID, Reddy, MA

Publicado 2023

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Background/Objectives: Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1. Subjects/Methods: Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods. Results: No associations were found between advanced maternal age, birth order or GDP per capita and the ratio of bilateral to unilate...

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artículo

Rising rural body-mass index is the main driver of the global obesity epidemic in adults.

Publicado por
Bixby, Honor, Bentham, James, Zhou, Bin, Di Cesare, Mariachiara, Paciorek, Christopher J., Bennett, James E., Taddei, Cristina, Stevens, Gretchen A., Rodriguez-Martinez, Andrea, Carrillo-Larco, Rodrigo M, Khang, Young-Ho, Soric, Maroje, Gregg, Edward W, Miranda, J. Jaime, Bhutta, Zulfiqar A., Savin, Stefan, Sophiea, Marisa K., Iurilli, Maria L. C., Solomon, Bethlehem D., Cowan, Melanie J., Riley, Leanne M., Danaei, Goodarz, Bovet, Pascal, Chirita-Emandi, Adela, Hambleton, Ian R., Hayes, Alison J., Ikeda, Nayu, Kengne, Andre P., Laxmaiah, Avula, Li, Yanping, McGarvey, Stephen T., Mostafa, Aya, Neovius, Martin, Starc, Gregor, Zainuddin, Ahmad A., NCD Risk Factor Collaboration (NCD-RisC)*

Publicado 2019

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NCD Risk Factor Collaboration (NCD-RisC)* Abarca-Gomez, Leandra Abdeen, Ziad A Abdrakhmanova, Shynar Abdul Ghaffar, Suhaila Abdul Hamid, Zargar Abubakar Garba, Jamila Abu-Rmeileh, Niveen M Acosta-Cazares, Benjamin Adams, Robert J Aekplakorn, Wichai Afsana, Kaosar Agdeppa, Imelda A Aguilar-Salinas, Carlos A Agyemang, Charles Ahmad, Mohamad Hasnan Ahmad, Noor Ani Ahmadi, Naser Ahmadvand, Alireza Ahrens, Wolfgang Ajlouni, Kamel AlBuhairan, Fadia AlDhukair, Shahla Al-Hazzaa, Hazzaa M Ali, Mohamed M Ali, Osman Alkerwi, Ala'a Al-Othman, Amani Rashed Al-Raddadi, Rajaa Alvarez-Pedrerol, Mar Aly, Eman Amarapurkar, Deepak N Amouyel, Philippe Amuzu, Antoinette Andersen, Lars Bo Anderssen, Sigmund A Angquist, Lars H Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Aounallah-Skhiri, Hajer Araujo, Joana Ariansen, Inger Aris, Tahir Arku, Raphael E Arlappa, Nimmathota Aryal, Krishna K Aspelund, Thor Assah...

4

artículo

Global Retinoblastoma Presentation and Analysis by National Income Level

Publicado por
Global Retinoblastoma Study Group, Fabian, ID, Abdallah, E, Abdullahi, SU, Abdulqader, RA, Adamou Boubacar, S, Ademola-Popoola, DS, Adio, A, Afshar, AR, Aggarwal, P, Aghaji, AE, Ahmad, A, Akib, MNR, Al Harby, L, Al Ani, MH, Alakbarova, A, Portabella, SA, Al-Badri, SAF, Alcasabas, APA, Al-Dahmash, SA, Alejos, A, Alemany-Rubio, E, Alfa Bio, AI, Alfonso Carreras, Y, Al-Haddad, C, Al-Hussaini, HHY, Ali, AM, Alia, DB, Al-Jadiry, MF, Al-Jumaily, U, Alkatan, HM, All-Eriksson, C, Al-Mafrachi, AARM, Almeida, AA, Alsawidi, KM, Al-Shaheen, AASM, Al-Shammary, EH, Amiruddin, PO, Antonino, R, Astbury, NJ, Atalay, HT, Atchaneeyasakul, LO, Atsiaya, R, Attaseth, T, Aung, TH, Ayala, S, Baizakova, B, Balaguer, J, Balayeva, R, Balwierz, W, Barranco, H, Bascaran, C, Beck Popovic, M, Benavides, R, Benmiloud, S, Guebessi, N, Berete, RC, Berry, JL, Bhaduri, A, Bhat, S, Biddulph, SJ, Biewald, EM, Bobrova, N, Boehme, M, Boldt, HC, Bonanomi, MTBC, Bornfeld, N, Bouda, GC, Bouguila, H, Boumedane, A, Brennan, RC, Brichard, BG, Buaboonnam, J, Calderón-Sotelo, P, Calle Jara, DA, Camuglia, JE, Cano, MR, Capra, M, Cassoux, N, Castela, G, Castillo, L, Català-Mora, J, Chantada, GL, Chaudhry, S, Chaugule, SS, Chauhan, A, Chawla, B, Chernodrinska, VS, Chiwanga, FS, Chuluunbat, T, ieslik KCockcroft, RL, Comsa, C, Correa, ZM, Correa Llano, MG, Corson, TW, Cowan-Lyn, KE, Csóka, M, Cui, X, Da Gama, IV

Publicado 2020

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Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale.