Resultados de Búsqueda por Autor

artículo

Treatment Outcomes and Definition Inconsistencies in High-Risk Unilateral Retinoblastoma

Publicado por
Arazi, M, Baum, A, Casavilca-Zambrano, S, Alarcon-Leon, S, Diaz-Coronado, R, Ahmad, Alia, Mushtaq, Asma, Hussain, M, Ushakova, T, Yuri, S, Vladimir, P, Shields, Cl, Eagle, RC, Berry, JL, Pike, S, Brown, B, Roy, Sr, Huque, F, Fabian, Ina, Frenkel, S, Eiger-Moscovich, Maya, Pe'er, J, Hubbard, GB, Olson, TA, Grossniklaus, H, Reddy, MA, Sagoo, MA, Staffieri, SE, Elder, JE, Mckenzie, JD, Tanabe, M, Kaliki, S, Fabian, ID

Publicado 2024

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Purpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition. Design: Retrospective multinational clinical cohort study. Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited. Centers retrieved clinical data and were asked to report detailed histopathology findings, as well as indicate cases defined locally as high-risk. For analysis, only unilateral cases with standardized HRHF, defined as retrolaminar optic nerve invasion, massive choroidal invasion, scleral invasion, anterior-segment involvement, and/or combined nonmassive choroidal and prelaminar/laminar optic nerve...

artículo

High-risk histopathological features of retinoblastoma following primary enucleation: A Global Study Of 1,426 Patients From 5 Continents

Publicado por
Kaliki, S, Vempuluru, VS, Bakal, KR, Dorji, S, Tanna, V, Shields, CN, Fallon, SJ, Raval, V, Ahmad, A, Mushtaq, A, Hussain, M, Yousef, YA, Mohammad, M, Roy, SR, Huque, F, Tatiana, U, Yuri, S, Vladimir, P, Zambrano, SC, Alarcón-León, S, Valdiviezo-Zapata, C, Vargas-Martorellet, M, Gutierrez-Chira, C, Buitrago, M, Ortiz, JS, Diaz-Coronado, R, Tripathy, D, Rath, S, Patil, G, Berry, JL, Pike, S, Brown, B, Tanabe, M, Frenkel, S, Eiger-Moscovich, M, Pe'er, J, Shields, CL, Eagle, RC,, Jr, Laiton, A, Velasco, AM, Vega, K, Desimone, J, Bejjanki, KM, Kapoor, AG, Venkataraman, A, Bryant, V, Reddy, MA, Sagoo, MS, Hubbard, GB, Azarcon, CP, Olson, TA, Grossniklaus, H, Rolfe, O, Staffieri, SE, O'day, R, Mathew, AA, Elder, JE, Mckenzie, JD, Fabian, ID, Shemesh, R, Vishnevskia-Dai, V, Ali, MH, Jakati, S, Mishra, DK, Palkonda, VAR

Publicado 2024

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Purpose: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. Methods: A retrospective study of 1,426 primarily enucleated retinoblastoma eyes from five continents. Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathological features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, P = 0.001), postlaminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, P = 0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, P = 0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, P = 0.68). Adjuvant chemotherapy with/withou...