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artículo

Treatment Outcomes and Definition Inconsistencies in High-Risk Unilateral Retinoblastoma

Publicado por
Arazi, M, Baum, A, Casavilca-Zambrano, S, Alarcon-Leon, S, Diaz-Coronado, R, Ahmad, Alia, Mushtaq, Asma, Hussain, M, Ushakova, T, Yuri, S, Vladimir, P, Shields, Cl, Eagle, RC, Berry, JL, Pike, S, Brown, B, Roy, Sr, Huque, F, Fabian, Ina, Frenkel, S, Eiger-Moscovich, Maya, Pe'er, J, Hubbard, GB, Olson, TA, Grossniklaus, H, Reddy, MA, Sagoo, MA, Staffieri, SE, Elder, JE, Mckenzie, JD, Tanabe, M, Kaliki, S, Fabian, ID

Publicado 2024

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Purpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition. Design: Retrospective multinational clinical cohort study. Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited. Centers retrieved clinical data and were asked to report detailed histopathology findings, as well as indicate cases defined locally as high-risk. For analysis, only unilateral cases with standardized HRHF, defined as retrolaminar optic nerve invasion, massive choroidal invasion, scleral invasion, anterior-segment involvement, and/or combined nonmassive choroidal and prelaminar/laminar optic nerve...