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Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer

Publicado por
Bonilla, CE, Montenegro, P, O-Connor, JM, Hernando-Requejo, O, Aranda, E, Pinto-Llerena, J, Llontop, A, Gallardo-Escobar, J, Diaz-Romero, MDC, Bautista-Hernandez, Y, Graña-Suarez, B, Batagelj, EJ, Wali-Mushtaq, A, Garcia-Foncillas, J

Publicado 2023

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Advances in genomic technologies have significantly improved the management of colorectal cancer (CRC). Several biomarkers have been identified in CRC that enable personalization in the use of biologic agents that have shown to enhance the clinical outcomes of patients. However, technologies used for their determination generate massive amounts of information that can be difficult for the clinician to interpret and use adequately. Through several discussion meetings, a group of oncology experts from Spain and several Latin American countries reviewed the latest literature to provide practical recommendations on the determination of biomarkers in CRC based on their clinical experience. The article also describes the importance of looking for additional prognostic biomarkers and the use of histopathology to establish an adequate molecular classification. Present and future of immunotherapy...

artículo

High-risk histopathological features of retinoblastoma following primary enucleation: A Global Study Of 1,426 Patients From 5 Continents

Publicado por
Kaliki, S, Vempuluru, VS, Bakal, KR, Dorji, S, Tanna, V, Shields, CN, Fallon, SJ, Raval, V, Ahmad, A, Mushtaq, A, Hussain, M, Yousef, YA, Mohammad, M, Roy, SR, Huque, F, Tatiana, U, Yuri, S, Vladimir, P, Zambrano, SC, Alarcón-León, S, Valdiviezo-Zapata, C, Vargas-Martorellet, M, Gutierrez-Chira, C, Buitrago, M, Ortiz, JS, Diaz-Coronado, R, Tripathy, D, Rath, S, Patil, G, Berry, JL, Pike, S, Brown, B, Tanabe, M, Frenkel, S, Eiger-Moscovich, M, Pe'er, J, Shields, CL, Eagle, RC,, Jr, Laiton, A, Velasco, AM, Vega, K, Desimone, J, Bejjanki, KM, Kapoor, AG, Venkataraman, A, Bryant, V, Reddy, MA, Sagoo, MS, Hubbard, GB, Azarcon, CP, Olson, TA, Grossniklaus, H, Rolfe, O, Staffieri, SE, O'day, R, Mathew, AA, Elder, JE, Mckenzie, JD, Fabian, ID, Shemesh, R, Vishnevskia-Dai, V, Ali, MH, Jakati, S, Mishra, DK, Palkonda, VAR

Publicado 2024

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Purpose: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. Methods: A retrospective study of 1,426 primarily enucleated retinoblastoma eyes from five continents. Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathological features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, P = 0.001), postlaminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, P = 0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, P = 0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, P = 0.68). Adjuvant chemotherapy with/withou...