Resultados de Búsqueda por Autor

artículo

Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma

Publicado por
Hicks, RM, Ji, X, Zou, Y, Sultana, S, Rashid, R, Sherief, ST, Cassoux, N, Garcia, Leon, JL, Diaz, Coronado, RY, López, AMZ, Ushakova, TL, Polyakov, VG, Roy, SR, Ahmad, A, Reddy, MA, Sagoo, MS, Harby, LA, Berry, JL, Polski, A, Astbury, NJ, Bascaran, C, Blum, S, Bowman, R, Burton, MJ, Gomel, N, Keren-Froim, N, Madgar, S, Zondervan, M, Kaliki, S, Fabian, ID, Stacey, AW

Publicado 2024

Enlace

PURPOSE. Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS. A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005. RESULTS. We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no signif...