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Neovascular Glaucoma as a Predictor of Retinoblastoma High-Risk Histopathology in an International Multicentre Study

Publicado por
Negretti, GS, Ushakova, T, Yuri, S, Vladimir, P, Berry, JL, Pike, S, Shields, CL, Hubbard, GB,, III, Eiger-Moscovich, M, Pe'er, J, Staffieri, SE, Elder, JE, McKenzie, JD, Ahmad, A, Hussain, M, Casavilca-Zambrano, S, Alarcon-Leon, S, Yousef, YA, Mohammad, M, Tanabe, M, Arazi, M, Fabian, ID, Goldstein, S, Kaliki, S, Sagoo, MS, Reddy, MA

Publicado 2024

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Purpose: To assess histopathology and outcomes following primary enucleation of eyes with retinoblastoma presenting with neovascular glaucoma (NVG). Methods: This was an international multi-centre case series study across five continents. Retrospective review of patient charts was performed for all patients undergoing primary enucleation for retinoblastoma (n=1420) using a standardised data-collection spreadsheet. Clinical features, pathological grade, and outcomes were compared between NVG patients and those with an American Joint Commission on Cancer (AJCC) 8th edition clinical stage of cT2. High-risk histopathology was defined as AJCC 8th edition pathological stage ≥pT2b. Results: NVG was seen in 224/1420 (16%) patients. Mean age at presentation of those with NVG was 30 months (median 25, range 0-120 months) and 131(58%) patients had high-risk histopathology. The univariate logistic...