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1
artículo
Publicado 2019
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When we refer to pain, we are faced with an unpleasant sensation that causes certain reactions in the human body that prevent its production, so it is of vital importance to understand what the symptomatology of pain is, how it is produced and how it can be avoided. production, there are cases where the pain becomes pathological where found in the patient's thoughts, therefore the present work tries to demonstrate that its production can be avoided in the face of intense painful situations that occur when working in the recovery of the mobility of the patient. articulation of the knee, which by its nature is painful, added to the fear of feeling pain on the part of the patient does not help the patient's recovery, the experimentation consists of taking the pain from the approach of not thinking about it and relaxing and evaluating it by an environment of cerebral analysis through the lev...
2
artículo
The need to develop a BCI brain- computer interface system for the control of a robotic arm in Peru arises from the possibility of interconnecting the human nervous system with a robotic or mechatronic system, and using this concept to recover some motor function. Brain Computer Interface (BCI) is a communication system based on the recording of brain signals (EEG). The electroencephalogram is the basis and support of the BCI technology. It is a novel technology that allows human-machine interaction in a virtual or physical environment, through a communication channel between the central nervous system and a robotic device. In recent years, the aforementioned systems have caused the interest of important research centers worldwide.
3
objeto de conferencia
In the present project it is focused on patients Amotrophy Lateral Sclerosis (ALS), so these patients do not have control of their motor functions therefore are unable to move on their own, requiring third party assistance to move with his wheelchair. Patients of Amyotrophic Lateral Sclerosis do not lose their cognitive ability, which is why you can use it to control his wheelchair as part of a computer chandler system using Cyton board of open BCI brain signals is extracted and with the help of deep learning classification of signals, so the patient can move their own means be held. In this project it was possible to perform communication computer brain, in addition to the proper functioning of the system, in addition it was possible to implement a security system that protects the patient against accidents, so the patient is safer to move; whole system gives the patient, partial indepe...
4
artículo
Publicado 2025
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Background: Disorders of gut–brain interaction (DGBI) are multifactorial. Early-life events are proposed as factors involved in their etiopathogenesis. The relationship between mode of delivery, prematurity, and DGBI development remains unclear. This study examines whether cesarean delivery and prematurity contribute to early childhood DGBI. Methods: Caregivers of children aged 1 month to 4 years from four Colombian cities participated in a cross-sectional study. Pediatricians completed the Spanish-validated Questionnaire of Pediatric Gastrointestinal Symptoms Rome IV (QPGS-IV). Data of children born by cesarean delivery and prematurity were compared with controls. Categorical data were analyzed using Fisher’s exact test, and odds ratios (ORs) with 95% confidence intervals (CIs). Results: DGBIs were identified in 26.6% of children, with functional constipation (FC) being the most pre...
5
artículo
Publicado 2020
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Objective: To describe the treatment of acute ischemic strokes with intravenous rtPA and determine the factors associated with the functional outcomes of patients treated with thrombolysis in a Peruvian hospital. Material and Methods: A prospective, longitudinal cohort study of patients with ischemic stroke who received rtPA over a period of 3 years was performed. The association of demographic and clinical data with functional status was assessed 3 months after the intervention. Simple and multivariate Poisson regression models were performed to evaluate associations with functional prognosis, and Relative Risk (RR) with a 95% confidence interval (CI) was used as a measure of association. Results: During the study period, 74 patients (1.19% of the total) received IV thrombolysis, and 68.18% of them achieved functional independence (mRS 0-2) at 90 days. We found a mortality of 6%, an int...
6
artículo
Introduction: Computed tomography (CT) is the primary diagnostic tool used in evaluating acute Trauma Brain Injury (TBI). Single-photon Emission Computerized Tomography (SPECT) is been used in TBI, with better results in brain functional evaluation than CT or MRI. Relationship between CT and SPECT after TBI was studied, but neurocognitive status is not included. Patients may have neurocognitive impairment with none or few abnormalities in structural images from CT. Material and Methods: Twenty patients between 16 and 60 years old with mild or moderate trauma brain injury were studied. CT scan, brain SPECT and neuropsychological evaluation were made at admission. Obtained data was matched. Results: CT scan and SPECT were abnormal in 16 and 19 patients. CT scan showed 15 brain lesions and SPECT 29 brain lesions. All patients with neurocognitive impairment had an abnormal SPECT. Discussion:...
7
artículo
Publicado 2016
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This paper intends to approach to the notion of ‘brain death’ as a paradigm used to determine ‘clinical death’, not as the death of the brain and the survival of the body, but rather as the cessation of all vital functions, i.e. death per se. This notion of ‘brain death’ will be analyzed based on what neurosciences can contribute today regarding the nature and complexity of the brain, and simultaneously, breaking new grounds when attempting to give an answer to this matter.
8
artículo
Publicado 2016
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This paper intends to approach to the notion of ‘brain death’ as a paradigm used to determine ‘clinical death’, not as the death of the brain and the survival of the body, but rather as the cessation of all vital functions, i.e. death per se. This notion of ‘brain death’ will be analyzed based on what neurosciences can contribute today regarding the nature and complexity of the brain, and simultaneously, breaking new grounds when attempting to give an answer to this matter.
9
artículo
Publicado 2024
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Exposure to high-altitude hypobaric hypoxia provides a useful pathophysiological model for studying the brain's response to reduced oxygen availability. In this study, gene expression was analyzed in different brain regions (hypothalamus, striatum, hippocampus, and cerebral cortex) of rats exposed to 3153 m a.s.l., focusing on markers of inflammation and cellular adaptation: NLRP3, IL-1β, and HIF-1α. For the samples obtained from each brain region, three consecutive procedures were performed following the manufacturer's instructions: total RNA extraction, reverse transcription to complementary DNA (cDNA), and quantification by real-time PCR (qPCR). Findings showed limited induction of NLRP3, whereas IL-1β and HIF-1α were markedly overexpressed. These results suggest that cerebral hypoxia triggers a sustained inflammatory response during the 28-day exposure period, accompanied by HI...
10
artículo
Publicado 2011
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Background: Maca, Lepidium meyenii walp, is a plant that grows in Peruvian Andes’ highlands. It is used as food because of its nutritional value and its ethnical and medical properties related to fertility and vitality. Currently public interest has increased on food and dietetic supplements that contain active principles like polyphenol compounds with inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities, thus improving cognitive functions through mechanisms yet unknown; for this reason maca has been proposed as an adaptogen that increases energy and resistance and diminishes stress. Objectives: To determine the energetic effect of yellow maca on memory and learning by biochemical tests, in an animal model of weaning rats. Design: Experimental study. Setting: Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Mar...
11
artículo
Publicado 2022
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Introducción: La enfermedad oncológica cerebral de tipo estesioneuroblastoma es un tumor poco frecuente, pero con extensiones que pueden llegar hasta la base del cráneo y, en ocasiones, puede presentar metástasis a grandes distancias que comúnmente llegan hasta los pulmones. Esta investigación tuvo como propósito, identificar y analizar los cambios neuropsicológicos antes y después de la intervención quirúrgica. Método: Se consideró apenas un participante para este estudio de caso, un hombre con 53 años que residía en la ciudad de Lisboa. Se aplicó un screening constituido por diversas subpruebas de la WISC y la figura compleja de Rey, además se evaluó la regulación emocional a partir de la prueba EADS. Resultados: En la evaluación preoperatoria se verificaron alteraciones significativas para la atención, memoria, funciones ejecutivas y todos...
12
artículo
Publicado 2025
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The relationship between executive functions (EF), creative personality, and academic performance in Argentine university students was examined. A total of 248 students (M = 22.97 years, SD = 4.43) from various Argentine provinces participated. The Adult Executive Functioning Inventory (ADEXI), the Cognitive Flexibility Scale, the Creative Behavior Scale (ECC), and the Creative Personality Scale (EPC) were used, along with academic performance data and sociodemographic information. Data were collected online through Google Forms and analyzed using Spearman correlations and mediation analysis with robust Maximum Likelihood estimator and Bootstrap. Cognitive flexibility exhibited the most robust correlation with grade point average (r = .281, p < .001), followed by working memory difficulties (r = -.234, p < .001). Creative personality correlated positively with grade point average (...
13
artículo
Publicado 2024
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The systematic review was carried out using the PRISMA methodology and focused on the search for scientific articles in which the effects of omega-3 or creatine supplementation in adults over 60 years of age and its effect on cognitive function had been investigated. The search criteria were supplementation, omega 3, creatine, older adults, memory, function and cognitive impairment. The exclusion criteria were athletes and people under 60 years of age. Articles from PubMed, ScienceDirect and SciELO were included. 223 articles were found investigating the effect of omega-3 supplementation and 25 articles on creatine supplementation, of which 29 and 3 were selected that met the inclusion and exclusion criteria respectively for each group. Concluding that adequate consumption of sources of omega 3 and creatine has a preventive benefit against memory conditions and cognitive deterioration re...
14
artículo
Publicado 2024
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The systematic review was carried out using the PRISMA methodology and focused on the search for scientific articles in which the effects of omega-3 or creatine supplementation in adults over 60 years of age and its effect on cognitive function had been investigated. The search criteria were supplementation, omega 3, creatine, older adults, memory, function and cognitive impairment. The exclusion criteria were athletes and people under 60 years of age. Articles from PubMed, ScienceDirect and SciELO were included. 223 articles were found investigating the effect of omega-3 supplementation and 25 articles on creatine supplementation, of which 29 and 3 were selected that met the inclusion and exclusion criteria respectively for each group. Concluding that adequate consumption of sources of omega 3 and creatine has a preventive benefit against memory conditions and cognitive deterioration re...
15
artículo
Publicado 2020
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Recent studies report a high prevalence of psychotic and substance use disorders sharing common brain mechanisms that may affect cognitive performance, response to treatment, the ability to commit to it and, consequently, increase the risk of relapse. Objective: To compare cognitive performance in patients with alcoholism and schizophrenia. Material and Methods: Observational study designed to evaluated 18 patients with schizophrenia and 32 with mental disorders due to alcohol consumption. The short neuropsychological battery NEUROPSI, validated in Spanish, was the main study instrument. Results: Significant differences were found between both groups in areas of executive function and long-term memory, with the sub-group of patients with schizophrenia showing greater deterioration levels. Conclusion: The results assist in explaining and understanding the difficulties that patients with s...
16
artículo
Publicado 2013
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Introduction: Computed tomography (CT) is the primary diagnostic tool used in evaluating acute Trauma Brain Injury (TBI). Single-photon Emission Computerized Tomography (SPECT) is been used in TBI, with better results in brain functional evaluation than CT or MRI. Relationship between CT and SPECT after TBI was studied, but neurocognitive status is not included. Patients may have neurocognitive impairment with none or few abnormalities in structural images from CT. Material and Methods: Twenty patients between 16 and 60 years old with mild or moderate trauma brain injury were studied. CT scan, brain SPECT and neuropsychological evaluation were made at admission. Obtained data was matched. Results: CT scan and SPECT were abnormal in 16 and 19 patients. CT scan showed 15 brain lesions and SPECT 29 brain lesions. All patients with neurocognitive impairment had an abnormal SPECT. Discussion:...
17
artículo
Publicado 2008
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This work has been supported by the Ministerio de Educación y Ciencia (BFU2005-02241/BFI), Spain and by the CONCYTEC: PROCYT project 2006, Peru. The authors thank Ewing Rafael Duque for his technical assistance, N. Skinner for stylistic revision of the English text and Professor Gerard Tramu (University of Bordeaux I, France) for kindly providing the CGRP antiserum.
18
artículo
Publicado 2025
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Objective: To validate a virtual reality (VR) model designed for neuroanatomy learning by evaluating its impact in terms of realism, usefulness, practicality, enjoyment, and recommendation. Materials and methods: A descriptive, instrument-validation study was conducted to assess the model through expert judgment in the field of neuroscience. Forty-two professionals in neurology, neurosurgery, and psychiatry participated in the study. The system was rated for realism, usefulness, practicality, enjoyment, and recommendation using a structured 13-item questionnaire based on a five-point Likert scale. The VR model, developed through advanced photogrammetry, enabled interactive manipulation of three-dimensional (3D) brain structures. Participants employed VR headsets and hand controllers to explore, in detail, the anatomical and functional relationships within the brain. Results: Participants...
19
artículo
Publicado 2025
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The paper analyzes the case of Adriana Smith, a pregnant woman who suffered brain death in Georgia, USA, and whose body was kept on life support to preserve the fetus despite her family’s opposition. From the perspective of Peruvian law, it examines the legal definition of death (irreversible cessation of brain activity) and the legal nature of the corpse as a sui generis object, protected by post-mortem rights derived from prior personality. It highlights that, in Peru, the unborn is recognized as a legal subject from conception, with special protection of life, constitutionally and legally acknowledged. Article 10 of the Civil Code allows the use of corpses to prolong human life, requiring that the family be informed but without needing their consent. Thus, preserving pregnancy through the maintenance of bodily functions would be legally valid, although it entails a delicate balance ...
20
tesis de grado
Publicado 2024
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El objetivo primordial del siguiente estudio del tema clínico ejecutado queda encaminado en un plan de interposiciones para el cuidado holístico del paciente, con los 11 patronos funcionales de Marjory Gordon, restituyendo así los patrones sobresaltados según nuestra evaluación, diagnosticado con esta patología Traumatismo craneocefalico utilizando las taxonomías NANDA, NIC Y NOC, se elaboró un proceso de atención de enfermería para el esmero adecuado y bienestar de una paciente en los días que estuvo hospitalizado en el Hospital de la policía Luis Sáenz. El presente estudio es un enfoque cuantitativo, de tipo descriptivo, de diseño no experimental y de corte transversal. En la cual se ejecutó la investigación de un caso clínico aplicado en la patología de un paciente, manejando los libros NANDA, NIC Y NOC, así finiquitar con los resultados alcanzados en la enfermería...
