Objective: To validate a virtual reality (VR) model designed for neuroanatomy learning by evaluating its impact in terms of realism, usefulness, practicality, enjoyment, and recommendation. Materials and methods: A descriptive, instrument-validation study was conducted to assess the model through expert judgment in the field of neuroscience. Forty-two professionals in neurology, neurosurgery, and psychiatry participated in the study. The system was rated for realism, usefulness, practicality, enjoyment, and recommendation using a structured 13-item questionnaire based on a five-point Likert scale. The VR model, developed through advanced photogrammetry, enabled interactive manipulation of three-dimensional (3D) brain structures. Participants employed VR headsets and hand controllers to explore, in detail, the anatomical and functional relationships within the brain. Results: Participants...