The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates the detoxification of these metabolites by conjugating them with glutathione. The presence of the CYP1A1*2A genetic variant intensifies the production of these reactive metabolites, and the deletion of the GSTM1 gene (GSTM1*0) impairs their detoxification. This enzymatic imbalance leads to the formation of DNA adducts, which are known to contribute to cancer and other diseases. Given the importance of studying these genes within the framework of 4P medicine (predictive, preventive, personalized, and participatory), the primary objective of this study was to investigate the prevalence of GSTM1*0 and CYP1A1*2A in the central Peruvian coastal Population as genetic biomarkers. The study included 131 individual residents of the Peruvi...

The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates the detoxification of these metabolites by conjugating them with glutathione. The presence of the CYP1A1*2A genetic variant intensifies the production of these reactive metabolites, and the deletion of the GSTM1 gene (GSTM1*0) impairs their detoxification. This enzymatic imbalance leads to the formation of DNA adducts, which are known to contribute to cancer and other diseases. Given the importance of studying these genes within the framework of 4P medicine (predictive, preventive, personalized, and participatory), the primary objective of this study was to investigate the prevalence of GSTM1*0 and CYP1A1*2A in the central Peruvian coastal Population as genetic biomarkers. The study included 131 individual residents of the Peruvi...

Background/Objectives: Epilepsy is characterized by recurrent, unprovoked, self-limiting seizures of genetic, acquired, or unknown origin. It affects more than 50 million people worldwide. The prevalence in Peru is 11.9–32.1 per 1000 people. Our objective was to describe the association between CYP2C9 and CYP2C19 genetic polymorphisms and adverse reactions induced by antiseizure medications among Peruvian patients with epilepsy. Methods: A descriptive observational study was conducted on Peruvian patients with epilepsy. Non-probability, non-randomized, purposive sampling was carried out through consecutive inclusion. Genomic DNA was obtained from venous blood samples. Genotypes were determined by real-time PCR using specific TaqMan probes to identify the alleles of interest. Results: In total, 89 Peruvian patients with epilepsy were recruited at the Alberto Sabogal Sologuren National H...

The presence of CYP1A1 allelic variants and deletion of the glutathione S-transferase GSTM1 gene, and their imbalance, have been suggested as risk factors for inducing colorectal cancer (CRCa). The objective was to identify CYP1A1 and GSTM1 and evaluate the association with the risk of developing colorectal cancer in a sample of cases and controls from Lima, Peru. This was a case-control study of CYP1A1 and GSTM1 genes in 50 samples from patients diagnosed with colorectal cancer and 50 samples from controls without cancer, using the PCR-based restriction fragment length polymorphism method. A significant risk of developing CRCa was found in the following groups: GSTM1*0 carriers with no history of smoking or family history of cancer (OR = 3.56, 95% CI 1.43–8.88, p = 0.0060); GSTM1*0 with family history of cancer without smoking (OR = 2.81, 95% CI 0.35–22.49, p = 0.3280); GSTM1*0 exac...