Letter to the Editor (without abstract)

Letter to the Editor (without abstract)

Objetivo: Determinar las variantes alélicas del gen CYP2C9 y la monitorización clínica del valproato en plasma como fundamento de la Medicina Personalizada. Material y métodos: Se utilizaron reactivos GR, estándar VPA USP y kit de extracción de ADN. Se determinó las variantes alélicas por Real Time PCR utilizando sondas TaqMan, y las concentraciones séricas por espectrofotometría UV/Vis a 210 nm. El tipo de estudio fue experimental, observacional, prospectivo de corte transversal. Se incluyó a 55 pacientes ambulatorios del HSJ-Callao, con diagnóstico de epilepsia según la definición de la ILAE, y que recibían VPA en monoterapia y con inductores; todos firmaron el consentimiento informado en forma individual y voluntaria. Resultados: Se encontró 10 pacientes con variantes alélicas, 06 fueron metabolizadores intermedios (MI) y 04 lentos (ML); mientras que 45 son metaboliza...

Introduction: Innovative and similar branded medications are expensive and are not accessible in the poorest sectors of Peru, hence the importance of having bioequivalent generic medications. This study aims to evaluate the in vitro biopharmaceutical quality of risperidone 2-mg tablets and their impact on public health. Methods: Four brands of risperidone from the local market were studied (two generic [G1T, G2A], one similar [M1], and one reference [R1]). An analytical and experimental study was conducted using a spectrophotometric method for the dissolution profile in a United States Pharmacopeia (USP) apparatus 2 at 50 rpm with 500 mL of dissolution medium at pH 1.2, 4.5, and 6.8, at 37 ± 0.5 °C. Weight, hardness, and friability were also evaluated. Similarity factor (f2), dissolution efficiency, and mean dissolution time were used as statistical indicators of biopharmaceutical qual...

The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates the detoxification of these metabolites by conjugating them with glutathione. The presence of the CYP1A1*2A genetic variant intensifies the production of these reactive metabolites, and the deletion of the GSTM1 gene (GSTM1*0) impairs their detoxification. This enzymatic imbalance leads to the formation of DNA adducts, which are known to contribute to cancer and other diseases. Given the importance of studying these genes within the framework of 4P medicine (predictive, preventive, personalized, and participatory), the primary objective of this study was to investigate the prevalence of GSTM1*0 and CYP1A1*2A in the central Peruvian coastal Population as genetic biomarkers. The study included 131 individual residents of the Peruvi...

The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates the detoxification of these metabolites by conjugating them with glutathione. The presence of the CYP1A1*2A genetic variant intensifies the production of these reactive metabolites, and the deletion of the GSTM1 gene (GSTM1*0) impairs their detoxification. This enzymatic imbalance leads to the formation of DNA adducts, which are known to contribute to cancer and other diseases. Given the importance of studying these genes within the framework of 4P medicine (predictive, preventive, personalized, and participatory), the primary objective of this study was to investigate the prevalence of GSTM1*0 and CYP1A1*2A in the central Peruvian coastal Population as genetic biomarkers. The study included 131 individual residents of the Peruvi...