Peripartum cardiomyopathy (PPCM) is a potentially life-threatening condition that can occur during the late pregnancy or puerperium. A 31-year-old woman with a recent twin pregnancy presented with heart failure symptoms nine days postpartum. On admission, she had volume overload and hemodynamic compromise, which was rapidly reversed with inotropic levosimendan support. Echocardiography revealed a left ventricular ejection fraction (LVEF) of 20% with global hypokinesia. Once stabilized, she was discharged on heart failure medication, bromocriptine, and warfarin. Cardiac magnetic resonance imaging at five weeks demonstrated a preserved LVEF of 57% and no evidence of myocardial scarring or edema. During the 4-year follow-up, the patient remained stable with no new pregnancies. This case highlights the importance of considering PPCM in the differential diagnosis of heart failure in t...

Introducción: A medida que la edad de diagnóstico de cáncer aumenta y la supervivencia mejora, el desarrollo de cardiotoxicidad relacionada con el tratamiento se vuelve más posible. Se necesitan datos epidemiológicos, ecocardiográficos y biomarcadores que ayuden a predecir el riesgo de toxicidad cardiovascular. Método: Este será un estudio de cohorte prospectivo observacional en el Hospital Nacional Edgardo Rebagliati Martins. Identificaremos pacientes mujeres entre los 30 y 70 años de edad con diagnóstico de cáncer de mama HER 2 positivo entre Enero y Junio del 2021, que recibirán Trastuzumab. Se recolectará datos epidemiológicos, biomarcadores y hallazgos ecocardiográficos basales, con seguimiento trimestral por 12 meses. Se realizará regresión de Cox para indentificar los factores de riesgo clínicos y laboratoriales para cardiotoxicidad.

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening condition that can occur during the late pregnancy or puerperium. A 31-year-old woman with a recent twin pregnancy presented with heart failure symptoms nine days postpartum. On admission, she had volume overload and hemodynamic compromise, which was rapidly reversed with inotropic levosimendan support. Echocardiography revealed a left ventricular ejection fraction (LVEF) of 20% with global hypokinesia. Once stabilized, she was discharged on heart failure medication, bromocriptine, and warfarin. Cardiac magnetic resonance imaging at five weeks demonstrated a preserved LVEF of 57% and no evidence of myocardial scarring or edema. During the 4-year follow-up, the patient remained stable with no new pregnancies. This case highlights the importance of considering PPCM in the differential diagnosis of heart failure in the perip...

Aims: Differentiation between patients with Takotsubo syndrome and acute coronary syndrome (ACS) remains a challenge. We performed a systematic review to identify and evaluate diagnostic predictive models to distinguish both conditions. Methods and results: We performed an electronic search in PubMed, EMBASE, and Scopus until January 2024. Observational studies that developed and/or validated multivariable diagnostic models to differentiate Takotsubo syndrome from ACS were included. The risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). We conducted a narrative synthesis of the performance measures of the diagnostic models evaluated in each study. In addition, a random-effects meta-analysis of the c-statistic with its 95% confidence interval (CI) of the InterTAK model was performed. Of 1015 articles, a total of 11 studies (n = 4552) were included...

Objetivo: Describir la evolución de pacientes con COVID-19 que desarrollaron síndrome coronario agudo (SICA) durante su hospitalización. Métodos: Estudio descriptivo de serie de casos. Se identificaron a pacientes que presentaron el diagnóstico de SICA durante su hospitalización por COVID-19 en el periodo marzo 2020 a marzo 2021 registrados en un estudio previo de los investigadores. Se realizó un seguimiento de los participantes hasta el final de la hospitalización. Se describieron las características clínicas de los participantes y se exploró la asociación entre el resultado final de la hospitalización y los factores registrados de interés mediante análisis bivariados no paramétricos y una regresión de Poisson robusta. Resultados: Se presentaron 38 casos de SICA sin elevación de ST (63,33%) y 22 con elevación del ST (36,67%). La mediana de la fracción de eyección f...