Objective: To analyze the association between blood glucose (BG) at admission and severe sepsis during hospitalization in non-diabetic patients admitted for infection. Material and method: An analytical, retrospective and cross-sectional study using clinical records of 140 non-diabetic patients admitted for infection to Hospital Regional Docente de Truijllo. BG was recorded on admission, divided by quartiles of the data obtained, and if they developed severe sepsis during hospitalization, also were registered: age, sex, place of infection, creatinine level and hospitalization time. The Gamma statistic was used to evaluate the association between main variables. Results: Mean BG=110.79 ± 25.4 mg/dL, yielding four working groups (G), according to quartiles: 92.75, 103 and 127 mg/dL. There were no significant differences between age, sex, place of infection, creatinine level and time of ho...

El síndrome de Cushing es un trastorno endocrino que causa infertilidad anovulatoria secundaria a hipercortisolismo; por lo tanto, el embarazo rara vez ocurre durante su curso. Presentamos el caso de una mujer de 24 años, gestante de 16 semanas, con aumento de peso no intencionado de 10 meses de evolución, giba dorsal, comedones no pruriginosos, hirsutismo y caída del cabello. Las investigaciones bioquímicas, hormonales y ecográficas iniciales revelaron hipopotasemia, aumento de la cortisolemia nocturna y una masa suprarrenal derecha. El paciente presentaba hipertensión arterial persistente, hiperglucemia e hipercortisolemia. Inicialmente fue tratada con medicamentos antihipertensivos y terapia con insulina. El síndrome de Cushing endógeno se confirmó mediante una resonancia magnética abdominal que demostró un adenoma suprarrenal derecho. El paciente fue sometido a suprarrena...

Aims: Differentiation between patients with Takotsubo syndrome and acute coronary syndrome (ACS) remains a challenge. We performed a systematic review to identify and evaluate diagnostic predictive models to distinguish both conditions. Methods and results: We performed an electronic search in PubMed, EMBASE, and Scopus until January 2024. Observational studies that developed and/or validated multivariable diagnostic models to differentiate Takotsubo syndrome from ACS were included. The risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). We conducted a narrative synthesis of the performance measures of the diagnostic models evaluated in each study. In addition, a random-effects meta-analysis of the c-statistic with its 95% confidence interval (CI) of the InterTAK model was performed. Of 1015 articles, a total of 11 studies (n = 4552) were included...

Objetivo: En feocromocitomas, la producción acelerada de catecolaminas puede causar diabetes secundaria. El gen responsable de los feocromocitomas relacionados con la neoplasia endocrina múltiple tipo 2 (MEN2) es el protooncogén RET . El objetivo de este informe es describir un caso único de remisión quirúrgica de diabetes mellitus tipo 2 (DM2) mal diagnosticada en una mujer con feocromocitoma bilateral y mutación del protooncogén RET . Métodos: Se realizó examen clínico, nivel de metanefrina en orina, tomografía computarizada (TC) abdominal trifásica con protocolo suprarrenal, tomografía por emisión de positrones con 18 F-fluorodesoxiglucosa integrada con TC, anatomía patológica y estudio genético. Resultados: Una mujer de 46 años con antecedentes de DM2 aparente complicada con neuropatía de 5 años de evolución, sin antecedentes familiares contribuyentes, presenta ...