Resultados de Búsqueda por Autor

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artículo

IFN-gamma production in response to Tax 161-233, and frequency of CD4(+) Foxp3(+) and Lin(-) HLA-DRhigh CD123(+) cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carri...

Publicado por
Best, I, Lopez, G, Verdonck, K, Gonzalez, E, Tipismana, M, Gotuzzo, E, Vanham, G, Clark, D

Publicado 2009

Enlace

Human T-lymphotropic virus 1 (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the pathogenesis of HAM/TSP by focusing on the CD8(+) T-cell response. Twenty-three HTLV-1-seronegative controls (SC), 29 asymptomatic HTLV-1 carriers (AC) and 48 patients with HAM/TSP were enrolled in the study. We evaluated the production of interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells stimulated with Tax overlapping peptides, the expression of genes related to the CD8(+) cytotoxic T-cell response, the frequency of CD4(+) Foxp3(+) cells and of dendritic cells, and the HTLV-1 provirus load (PVL). The frequency of cells producing IFN-gamma in response to Tax 161-233, but not to Tax 11-19, discriminated patients with HAM/TSP from AC. The increased pro-inflammatory response observed in patients with H...

2

artículo

Short Communication An Interferon-gamma ELISPOT Assay with Two Cytotoxic T Cell Epitopes Derived from HTLV-1 Tax Region 161-233 Discriminates HTLV-1-Associated Myelopathy/Tropical...

Publicado por
Best, I, Lopez, G, Talledo, M, MacNamara, A, Verdonck, K, Gonzalez, E, Tipismana, M, Asquith, B, Gotuzzo, E, Vanham, G, Clark, D

Publicado 2011

Enlace

We thank the staff at the Instituto de Medicina Tropical Alexander von Humboldt for their valuable assistance in their attention to the HTLV-1-infected people. This work was supported by the Directorate-General for Development Cooperation of the Belgian Government through the Framework Agreement with the Institute of Tropical Medicine of Antwerp and through the Flemish Interuniversity Council (VLIR), and by the Peruvian National Board for Science and Technology (CONCYTEC).

3

artículo

Building a network for multicenter, prospective research of central nervous system infections in South America: process and lessons learned.

Publicado por
Delgado, A., Nelson, Christina, Mori, Nicanor, Thanh Ton, Zunt, Joseph, Kochel, T., Romero, A., Gadea, N., Tilley, D., Ticona, E., Soria, J., Celis, V., Huanca, D., Rivas, M., Stiglich, M., Sihuincha, M., Donayre, G., Celis, J., Romero, R., Tam, N., Tipismana, M., Espinoza, I., Rozas, M., Peralta, A., Sanchez, E., Vasquez, L., Muñoz, P., Ramirez, G., Reyes, I.

Publicado 2018

Enlace

Las redes de colaboración de multicentros son esenciales para el avance de la investigación y mejorando la atención clínica de variedad de condiciones. La redes de investigación son particularmente importantes para las infecciones del sistema nervioso central, las cuales son difíciles de estudiar. Se revisa nuestra experiencia de desarrollo de redes de investigación en encefalitis en doce hospitales de cinco ciudades peruanas desde el año 2009, y se presentan sugerencias prácticas para ayudar a otros grupos de investigación en áreas de recursos limitados.