Abstract Drug-induced esophageal ulcers constitute an acquired chemical injury to the esophageal mucosa, most frequently associated with tetracyclines, particularly doxycycline. We report a case of "kissing ulcers" diagnosed through esophagogastroduodenoscopy in a young woman undergoing doxycycline treatment for rosacea. The pathogenesis is linked to drug-specific factors, such as caustic effects, hyperosmolar properties, and prolonged mucosal contact with the medication, in addition to patient-specific risks, including esophageal motility disorders, reduced saliva production, and mid-esophageal anatomical compression. Clinically, patients commonly present with abrupt-onset chest pain, dysphagia, and odynophagia, while endoscopic findings often reveal mucosal erythema, erosions, and specular distribution esophageal ulcers (referred to as “kissing ulcers”). Management involves discont...

Latin America presents a high prevalence of Helicobacter pylori (Hp) infection. Between 1996-2003, the prevalence in Santiago, Chile, was 70%; recent studies indicate a decrease in this infection. Updating the frequency of Hp is crucial due to its associated health impact. Objective: Our objective was to describe the trend in Hp infection in patients undergoing ambulatory esophagogastroduodenoscopy (EGD) in a Chilean population. Materials and methods: A retrospective observational study was conducted on patients over 18 years old who attended a first EGD with a rapid urease test between 2010-2020. Time trends were described through time series analysis. A Poisson model was constructed to estimate the risk of infection, adjusted for age and gender. Results: 11,355 patients were included [66.9% females; mean age 52 years; Hp 41.6%]. Male gender presented a higher frequency of Hp infection ...

El artículo tiene por objetivo analizar y encontrar la valoración de la satisfacción laboral en relación con la cultura organizacional y el compromiso cristiano de 426 docentes de la Universidad Peruana Unión de Lima durante el periodo 2013. El diseño utilizado corresponde a un tipo descriptivo correlacional, pues las variables de estudio ya existen en la realidad. La técnica de análisis que se utiliza corresponde a una correlación múltiple con cierta causalidad que pretende explicar las relaciones existentes entre las variables estudiadas estableciendo una dirección, identificando cuáles son las causas y efectos. Es decir se trató de establecer la contribución independiente de diversas variables predictoras sobre la variable criterio. Considerando el análisis de regresión múltiple para explicar los distintos modelos según las hipótesis de trabajo formuladas se llegó ...

La investigación tuvo como problema: ¿De qué manera se aplican la validez normativa y las técnicas de interpretación jurídica en la Sentencia Casatoria N° 456-2012 Del Santa emitida por la Corte Suprema, en el expediente Nº 1278-2011-23-2501-JR-PE-01 , del Distrito Judicial del Santa – Chimbote, 2020?; el objetivo general fue: Determinar la aplicación de la validez normativa y las técnicas de interpretación jurídica en la Sentencia Casatoria N° 456-2012 del Santa emitida por la Corte Suprema. Es tipo cuantitativo cualitativo (mixto); nivel exploratorio – hermenéutico; diseño método hermenéutico dialéctico. La unidad muestral fue un expediente judicial, seleccionado mediante muestreo por conveniencia; para recolectar los datos se utilizó las técnicas de la observación y el análisis de contenido; y como instrumento una lista de cotejo, validado mediante juicio de ...

La investigación tiene el objetivo de analizar y encontrar la valoración de la satisfacción laboral en relación con la cultura organizacional y el compromiso cristiano de 426 docentes de la Universidad Peruana Unión de Lima durante el periodo 2013. El diseño de la investigación corresponde a un tipo correlacional, pues las variables de estudio ya existen en la realidad y, por lo tanto, no se manipula ninguna variable, tampoco se agrupan a los sujetos de la muestra siguiendo un criterio determinado. La técnica de análisis que se utiliza corresponde a una correlación múltiple con cierta causalidad, pretende explicar las relaciones existentes entra las variables estudiadas, estableciendo una dirección, identificando cuáles son las causas y efectos. Es decir, se trató de establecer la contribución independiente de diversas variables predictoras sobre la variable criterio. El n...

This study chooses to determine the association between personal and work factors, and Burnout syndrome in nursing professionals at the Chepén Support Hospital, within the framework of the COVID-19 pandemic in the different hospitalization services. It is descriptive, quantitative, non-experimental, correlational and cross-sectional, with a sample population of 45 nurses. Regarding the collection of information, a questionnaire on labor factors and the presence of Burnout syndrome was applied. The data obtained were analyzed with the SPSS V25 program. The CHI square (X2) statistical test was applied, with a 95% confidence interval at a significance level of 5%. Finally, we reach the conclusion that the nursing professionals evaluated have been affected to a greater extent at a moderate level and to a lesser extent at a mild level; Therefore, their performance at the work level will be a...

Por su presunción de validez los actos administrativos de determinación de obligaciones tributarias (incluso de tipo definitivo) no deben ser revisados a iniciativa de la propia administración salvo que exista una causal legal que lo habilite. En materia tributaria dichas causales son especiales y la realidad las ha sobrepasado. Aun subsiste la reforma peyorativa (que merece ser revisada para evitar su inutilidad) y la posibilidad de revisar los actos de la Administración Tributaria invocando causales no expresas en la ley, así como causales que tienen que aplicarse conforme a los efectos de los tratados internacionales. Se refuerza la irrevisibilidad del acto producto de la fiscalización pero persiste, sobre la base del deber de contribuir, la necesidad de invocar causales extra legales con contenido valioso para afectar el carácter de integral, único y definitivo de la fiscaliz...

Potato plants are often subjected to heat stress during growth and development, resulting in loss of yield and quality. However, the possibility exists that commercially important genotypes show tolerance to heat stress. In this study, we aim to investigate the morphological and physiological effects of moderate conditions of heat stress on tuberization in nine potato genotypes, and how it affects propagation using an ex vitro and in vitro system. The plant material came from the In Vitro Germplasm Bank of the International Potato Center (CIP). The incubation temperatures of the cultures in in vitro and ex vitro conditions were the ambient in the laboratory and greenhouse, respectively. In in vitro system a randomized complete block design was employed in nine genotypes, two treatments: multiplication culture medium and the same culture medium supplemented with 8.0% sucrose and 500 mg/L-...

Endoscopic intermuscular dissection (EID) emerges as an alternative for the treatment of patients with rectal lesions with suspected deep invasion or with extensive fibrosis which are not candidates for endoscopic submucosal dissection (ESD). In EID the dissection is performed between the inner (circular) and outer (longitudinal) layers of the muscularis propia. We present the case of a patient successfully treated with EID technique. 54-year-old female patient with a history sessile adenomatous lesion of the rectum of approximately 40 mm resected with conventional endoscopic mucosal resection technique. She presented a recurrence of the lesion on the prior resection scar. EID was performed on the scar of prior endoscopic resection, accessing and exposing the intermuscular plane. En bloc resection of the lesion was achieved with negative histological lateral and deep margins, fulfilling ...

The Amazon rainforest is one of the most biodiverse and at the same time most threatened ecosystems in the biosphere. Its different habitats provide a unique floristic pattern. Therefore, we aimed to identify the floristic arboreal composition in an area of the Amazon rainforest and determine the local patterns of diversity in its different habitats. This study was conducted around the Tambopata Research Center, Madre de Dios, Peru. To achieve our goals, we established 20 (50 × 30 m) plots distributed equally in four habitats, these being: Mauritia Palm Swamp, Floodplain Forest, Successional Floodplain Forest, and Tierra Firme Forest. In each plot, we collected all individuals with a diameter at a breast height ≥ of 10 cm. Subsequently, the individuals were identified and classified by cluster and diversity analysis. We found 57 families, 173 genera, 300 species, and 1958 individuals....

The Amazon rainforest is one of the most biodiverse and at the same time most threatened ecosystems in the biosphere. Its different habitats provide a unique floristic pattern. Therefore, we aimed to identify the floristic arboreal composition in an area of the Amazon rainforest and determine the local patterns of diversity in its different habitats. This study was conducted around the Tambopata Research Center, Madre de Dios, Peru. To achieve our goals, we established 20 (50 × 30 m) plots distributed equally in four habitats, these being: Mauritia Palm Swamp, Floodplain Forest, Successional Floodplain Forest, and Tierra Firme Forest. In each plot, we collected all individuals with a diameter at a breast height ≥ of 10 cm. Subsequently, the individuals were identified and classified by cluster and diversity analysis. We found 57 families, 173 genera, 300 species, and 1958 individuals....

Introduction: Esophageal adenocarcinoma (EAC) is increasing in Western countries, and Barrett’s esophagus (BE) represents its only known premalignant condition. BE affects approximately 1–2% of the general population and up to 14% of patients with gastroesophageal reflux disease (GERD). Data from Latin America and Chile remain limited. Objectives: To determine the prevalence of BE, the neoplasia detection rate (NDR), and the endoscopic quality criteria associated with neoplasia detection in a Chilean university center. Materials and methods: A longitudinal cohort study including all patients with BE identified among upper gastrointestinal endoscopies performed at the Red de Salud UC CHRISTUS between January 2015 and December 2022. Patients with a history of other digestive neoplasms or referred with previously diagnosed BE/EAC were excluded. Demographic, endoscopic, and histopatholog...

Los aceites esenciales de especies amazónicas están ganando un creciente interés en todo el mundo debido a sus aplicaciones medicinales y cosméticas; sin embargo, la relación entre los constituyentes químicos y sus propiedades biológicas no está bien explorada. Por lo tanto, la presente investigación tiene como objetivo obtener una comprensión de la bioactividad de los compuestos químicos en los aceites esenciales de plantas de la familia Annonaceae (Bocageopsis pleiosperma, Onychopetalum amazonicum, Unonopsis duckei, U. floribunda, U. rufescens, U. stipitata, U. guatterioides, Duguetia flagellaris y Xylopia benthamii). Mediante cromatografía de gases acoplada a espectrometría de masas, ensayos citotóxicos y antilipasa in vitro, análisis de componentes principales y acoplamiento molecular, fue posible establecer los principales compuestos que pueden ser responsables del ef...