1
artículo
Publicado 2015
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The aim of this study was to establish the frequency of resistance and susceptible genotypes to scrapie in the Junin sheep breed. For this, 56 blood samples were collected in a sheep farm in the central highlands of Peru. The DNA was extracted and the PCR products were analyzed by enzymatic digestion using restriction endonucleases that recognize the PrP gene polymorphisms. Four of the 5 haplotypes reported for the PrP gene were identified: ARR (48.2%), ARQ (35.7%), AHQ (10.7%) and VRQ (5.4%). In addition, 7 of the 15 reported genotypes for the Prion gene were found: ARR/ARR (17.9%), ARR/AHQ (10.7%), ARR/ARQ (42.9%), ARQ/AHQ (10.7%), ARQ/ARQ (7.1%), ARR/VRQ (7.1%) and ARQ/VRQ (3.6%). Finally, 82.1% of the animals had genotypes resistant to the disease and 17.9% showed genotypes of susceptibility.
2
artículo
Publicado 2015
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The aim of this study was to establish the frequency of resistance and susceptible genotypes to scrapie in the Junin sheep breed. For this, 56 blood samples were collected in a sheep farm in the central highlands of Peru. The DNA was extracted and the PCR products were analyzed by enzymatic digestion using restriction endonucleases that recognize the PrP gene polymorphisms. Four of the 5 haplotypes reported for the PrP gene were identified: ARR (48.2%), ARQ (35.7%), AHQ (10.7%) and VRQ (5.4%). In addition, 7 of the 15 reported genotypes for the Prion gene were found: ARR/ARR (17.9%), ARR/AHQ (10.7%), ARR/ARQ (42.9%), ARQ/AHQ (10.7%), ARQ/ARQ (7.1%), ARR/VRQ (7.1%) and ARQ/VRQ (3.6%). Finally, 82.1% of the animals had genotypes resistant to the disease and 17.9% showed genotypes of susceptibility.
3
artículo
Publicado 2008
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Introducción: En Perú la incidencia de glomeruloesclerosis focal y segmentaria primaria ha aumentado considerablemente durante la última década y actualmente es la primera causa de glomerulonefritis primaria en adultos. Por su prevalencia y alta probabilidad de progresar a insuficiencia renal crónica terminal, se buscaron factores con valor pronóstico para supervivencia renal y remisión de proteinuria. Pacientes y métodos: Cohorte histórica de 44 pacientes. Estudiamos las características clínicas e histológicas al momento de la biopsia renal y la función renal al seguimiento. ≥Los desenlaces principales fueron: deterioro renal (incremento de creatinina 50% y/o insuficiencia renal terminal) y remisión de proteinuria (parcial 0,3-3,49 g/día y completa < 0,3 g/día). Se usaron curvas de Kaplan-Meier y regresión multivariable de Cox. Resultados: El 59% de los pacientes fuer...
4
artículo
Publicado 2021
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Several studies have shown that the main problem in the construction industry is low productivity. Therefore, this study focuses on developing a proposal through a methodology that can increase productivity in the construction of buildings. The proposed methodology is Virtual Design and Construction (VDC), which has 4 pillars: Building Information Modeling (BIM), Integrated Concurrent Engineering (ICE), metrics and Project Production Management (PPM). However, the article mainly develops BIM and ICE sessions. In addition, in the ICE sessions, "work executors"will be added, so that the information is fed back by both parties, specialist engineers and work executors. Finally, the proposal will be applied in a multi-family building project in the city of Lima - Peru, in order to obtain improvement results.
5
artículo
Publicado 2021
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The aim of this study was to evaluate the digestibility of nutrients and digestible and metabolizable energy of precooked and processed (pelletized and extruded) of seed and meal of sacha inchi (Plukenetia volubilis L) in guinea pigs. In each trial, 15 male guinea pigs, 3 months old and average weight of 700 g, were used. Pelletizing was carried out at 87 °C and extrusion at 105 °C. The digestibility and metabolic tests were determined using the substitution method and total excreta collection (faeces and urine). The apparent digestibility values (%) for dry matter, crude protein, crude fibre and ethereal extract for the pelleted seed were 54.4, 79.6, 27.0, 76.1 and for extruded seed were 48.7, 83.5, 16.2 and 81.7 respectively; while for pelletized cake were 82.5, 81.2, 98.7 and 65.9 and for extruded cake were 76.7, 83.2, 92.8 and 62.4. The digestible energy in the pelletized and extru...
6
artículo
Publicado 2021
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El estudio tuvo como objetivo evaluar la digestibilidad de los nutrientes y energía digestible y metabolizable de la semilla y torta de sacha inchi (Plukenetia volubilis L) precocida y procesada (peletizado y extruido) en cuyes. En cada ensayo se utilizaron 15 cuyes machos, de 3 meses edad y peso promedio de 700 g. El peletizado se realizó a 87 °C y la extrusión a 105 °C. La digestibilidad y metabolicidad fue determinada utilizando el método de sustitución y colección total de excretas (heces y orina). Los valores de digestibilidad aparente (%) para materia seca, proteína bruta, fibra cruda y extracto etéreo para la semilla peletizada fueron de 54.4, 79.6, 27.0, 76.1 y semilla extruida de 48.7, 83.5, 16.2 y 81.7 respectivamente; mientras que para torta peletizada fueron de 82.5, 81.2, 98.7, 65.9 y torta extruida 76.7, 83.2, 92.8 y 62.4. La energía digestible en la semilla pele...
7
artículo
Publicado 2019
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Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in suscept...
