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artículo
Publicado 2022
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Objective: To characterize the geriatric patient profile and identify the mortality-associated factors in a population over 80 years hospitalized with COVID-19 infection in the geriatric ward of a university hospital in the city of Bogotá.Materials and methods: An analytical observational retrospective cohort study based on chart reviews was conducted. The study included patients over 80 years with confirmed COVID-19 infection from March 1, 2020 to February 28, 2021. The dependent variable was mortality and the independent variables were age, clinical factors, baseline characteristics and paraclinical status.Results: Two hundred eighty (280) patients with a median age of 84 years, most of whom were overweight, were identified. The most frequent symptom was cough followed by dyspnea. Out of all patients, 60.3 % presented lymphopenia and elevated D-dimer levels (> 1,000 μg/L), and mos...
2
artículo
Publicado 2023
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Introduction. There is a knowledge gap concerning patients with acute myeloid leukemia (AML) who are not eligible for intensive induction chemothera-py; this, together with a recent increase in the incidence in Latin America, encloses a need. Through real-world evidence, we describe and compare the results of the different treatment strategies within this context. Methodology. This is a longitu-dinal, descriptive, retrospective study of a cohort of Latin American patients with AML not eligible for intensive induction chemotherapy, treated with low-intensity chemotherapy or with the best supportive care alone between January 1, 2015, to December 31, 2018. Results. Of a total of 125 patients (median age 74.8 years), the majority received low-intensity chemotherapy (78.4%). The median time in months of overall survival (9.2), progression-free survival (4.8), and time to treatment failure (3...
3
artículo
Publicado 2019
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Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in suscept...
