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DataSheet_1_Preclinical Assessment of IgY Antibodies Against Recombinant SARS-CoV-2 RBD Protein for Prophylaxis and Post-Infection Treatment of COVID-19.docx
Publicado por
Agurto-Arteaga, Andres, Poma-Acevedo, Astrid, Rios-Matos, Dora, Choque-Guevara, Ricardo, Montesinos-Millán, Ricardo, Montalván, Ángela, Isasi-Rivas, Gisela, Cauna-Orocollo, Yudith, Cauti-Mendoza, María de Grecia, Pérez-Martínez, Norma, Gutierrez-Manchay, Kristel, Ramirez-Ortiz, Ingrid, Núñez-Fernández, Dennis, Salguedo-Bohorquez, Mario I., Quiñones-Garcia, Stefany, Fernández Díaz, Manolo, Guevara Sarmiento, Luis A., Zimic, Mirko, COVID-19 Working Group in Peru
Publicado 2022 Enlace
Within the framework of the current COVID-19 pandemic, there is a race against time to find therapies for the outbreak to be controlled. Since vaccines are still tedious to develop and partially available for low-income countries, passive immunity based on egg-yolk antibodies (IgY) is presented as a suitable approach to preclude potential death of infected patients, based on its high specificity/avidity/production yield, cost-effective manufacture, and ease of administration. In the present study, IgY antibodies against a recombinant RBD protein of SARS-CoV-2 were produced in specific-pathogen-free chickens and purified from eggs using a biocompatible method. In vitro immunoreactivity was tested, finding high recognition and neutralization values. Safety was also demonstrated prior to efficacy evaluation, in which body weight, kinematics, and histopathological assessments of hamsters cha...
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artículo
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M<sup>PRO</sup>
Publicado por
Jiménez-Avalos, Gabriel, Vargas-Ruiz, A. Paula, Delgado-Pease, Nicolás E., Olivos-Ramirez, Gustavo E., Sheen, Patricia, Fernández-Díaz, Manolo, Quiliano, Miguel, Zimic, Mirko, Agurto-Arteaga, Andres, Antiparra, Ricardo, Ardiles-Reyes, Manuel, Calderon, Katherine, Cauna-Orocollo, Yudith, de Grecia Cauti-Mendoza, Maria, Chipana-Flores, Naer, Choque-Guevara, Ricardo, Chunga-Girón, Xiomara, Criollo-Orozco, Manuel, De La Cruz, Lewis, Delgado-Ccancce, Elmer, Elugo-Guevara, Christian, Fernández-Sanchez, Manolo, Guevara-Sarmiento, Luis, Gutiérrez, Kristel, Heredia-Almeyda, Oscar, Huaccachi-Gonzalez, Edison, Huerta-Roque, Pedro, Icochea, Eliana, Isasi-Rivas, Gisela, Juscamaita-Bartra, Romina A., Licla-Inca, Abraham, Montalvan, Angela, Montesinos-Millan, Ricardo, Núñez-Fernández, Dennis, Ochoa-Ortiz, Adiana, Páucar-Montoro, Erika, Pauyac, Kathy, Perez-Martinez, Jose L., Perez-M, Norma, Poma-Acevedo, Astrid, Quiñones-Garcia, Stefany, Ramirez-Ortiz, Ingrid, Ramos-Sono, Daniel, Rios-Angulo, Angela A., Rios-Matos, Dora, Rojas-Neyra, Aldo, Romero, Yomara K., Salguedo-Bohorquez, Mario I., Sernaque-Aguilar, Yacory, Soto, Luis F., Tataje-Lavanda, Luis, Ticona, Julio, Vallejos-Sánchez, Katherine, Villanueva-Pérez, Doris, Ygnacio-Aguirre, Freddy
Publicado 2021 Enlace
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
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