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artículo

Evaluation of the oncolytic activity of Newcastle disease virus (rLS1) in human prostate and renal carcinoma cell lines

Publicado por
Guerrero-Fonseca, Gloria, Carbajal-Lévano, Brigith, Rojas-Neyra, Aldo, Poma-Acevedo, Astrid, Ygnacio, Freddy, Calderón, Katherine, Fernández-Sánchez, Manolo, Fernández-Díaz, Manolo

Publicado 2025

Enlace

Introduction. Oncolytic virotherapy has emerged as a novel method for treating cancer. The newcastle disease virus (ndv) exhibits oncolytic potential and selectively replicates in tumor cells. Human prostate and renal cancer are the leading causes of death worldwide. Objective. To evaluate the oncolytic activity of the rLS1 viral construct on prostate carcinoma (DU-145) and renal cancer (786-O) cell lines, as well as its selective replication in both tumor lines and the non-tumoral madin-darby canine kidney (MDCK) cell line. Methods. The oncolytic effectiveness was determined by reducing cell viability and apoptosis using the (3-[4,5-dimethylthiazol-2-yl]-5-[3-carboxymethoxyphenyl]-2-[4-sulfophenyl]-2h-tetrazolium) MTS colorimetric assay and by labeling with annexin v/anxa5-pe/sytox blue dead cell, respectively. The viral replicative selectivity in cells was evaluated by crystal violet s...

artículo

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M<sup>PRO</sup>

Publicado por
Jiménez-Avalos, Gabriel, Vargas-Ruiz, A. Paula, Delgado-Pease, Nicolás E., Olivos-Ramirez, Gustavo E., Sheen, Patricia, Fernández-Díaz, Manolo, Quiliano, Miguel, Zimic, Mirko, Agurto-Arteaga, Andres, Antiparra, Ricardo, Ardiles-Reyes, Manuel, Calderon, Katherine, Cauna-Orocollo, Yudith, de Grecia Cauti-Mendoza, Maria, Chipana-Flores, Naer, Choque-Guevara, Ricardo, Chunga-Girón, Xiomara, Criollo-Orozco, Manuel, De La Cruz, Lewis, Delgado-Ccancce, Elmer, Elugo-Guevara, Christian, Fernández-Sanchez, Manolo, Guevara-Sarmiento, Luis, Gutiérrez, Kristel, Heredia-Almeyda, Oscar, Huaccachi-Gonzalez, Edison, Huerta-Roque, Pedro, Icochea, Eliana, Isasi-Rivas, Gisela, Juscamaita-Bartra, Romina A., Licla-Inca, Abraham, Montalvan, Angela, Montesinos-Millan, Ricardo, Núñez-Fernández, Dennis, Ochoa-Ortiz, Adiana, Páucar-Montoro, Erika, Pauyac, Kathy, Perez-Martinez, Jose L., Perez-M, Norma, Poma-Acevedo, Astrid, Quiñones-Garcia, Stefany, Ramirez-Ortiz, Ingrid, Ramos-Sono, Daniel, Rios-Angulo, Angela A., Rios-Matos, Dora, Rojas-Neyra, Aldo, Romero, Yomara K., Salguedo-Bohorquez, Mario I., Sernaque-Aguilar, Yacory, Soto, Luis F., Tataje-Lavanda, Luis, Ticona, Julio, Vallejos-Sánchez, Katherine, Villanueva-Pérez, Doris, Ygnacio-Aguirre, Freddy

Publicado 2021

Enlace

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.