We present the first case of application of therapeutic hypothermia in a newborn with a diagnosis of moderate ischemic hypoxic encephalopathy with the inclusion criterias. Risk factors, diagnostic criteria, evolution and monitoring during hypothermia and the followed-up post-discharge, are reported in our institution.

We present the first case of application of therapeutic hypothermia in a newborn with a diagnosis of moderate ischemic hypoxic encephalopathy with the inclusion criterias. Risk factors, diagnostic criteria, evolution and monitoring during hypothermia and the followed-up post-discharge, are reported in our institution.

ABSTRACTMaple syrup urine disease is a congenital metabolic disorder, commonly presenting as acute neonatal encephalopathy.Case 1. A 7-day-old neonate exhibited somnolence and refusal to breastfeed, later developing respiratory failure, neurological impairment, metabolic acidosis, and death. Elevated levels of branched-chain amino acids and a confirmatorygenetic test established the diagnosis. Case 2. A 10-day-old neonate was admitted with breastfeeding refusal, hypoglycemia, and seizures. Elevated branched-chain amino acids confirmed the diagnosis genetically. The patient receivedparenteral nutrition and a special formula, leading to progressive neurological improvement. Currently, at 2 years and 7months, the patient remains under multidisciplinary follow-up. Conclusion. Early detection of maple syrup urine diseasethrough neonatal screening significantly improves neurological outcomes.Â...

ABSTRACTMaple syrup urine disease is a congenital metabolic disorder, commonly presenting as acute neonatal encephalopathy.Case 1. A 7-day-old neonate exhibited somnolence and refusal to breastfeed, later developing respiratory failure, neurological impairment, metabolic acidosis, and death. Elevated levels of branched-chain amino acids and a confirmatorygenetic test established the diagnosis. Case 2. A 10-day-old neonate was admitted with breastfeeding refusal, hypoglycemia, and seizures. Elevated branched-chain amino acids confirmed the diagnosis genetically. The patient receivedparenteral nutrition and a special formula, leading to progressive neurological improvement. Currently, at 2 years and 7months, the patient remains under multidisciplinary follow-up. Conclusion. Early detection of maple syrup urine diseasethrough neonatal screening significantly improves neurological outcomes.Â...

El objetivo del estudio fue analizar el uso de la punción lumbar (PL) en las sospechas de sepsis neonatal tardía. Se utilizó una cohorte de 414 neonatos con peso al nacer <2000 g en tres hospitales de Lima. Se realizó la PL en 45/214 (21,0%) sospechas de sepsis y en 13/48 (27,1%) sepsis confirmadas por hemocultivo. Se diagnosticó meningitis en 8/214 (3,7%) sospechas y en 8/45 (17,5%) episodios en los que se realizó la PL. El tiempo de tratamiento de los episodios sin PL fue similar a los episodios de sepsis con meningitis descartada y menor a los episodios de meningitis. El uso de la PL es bajo, lo que puede resultar en meningitis no diagnosticadas y tratadas inadecuadamente.

We report the first successful case of fetal surgery for spina bifida repair in Peru. A pregnant woman was referred to our center at 23 weeks’ gestation because of prenatal diagnosis of spina bifida. We formed a multidisciplinary international team with the goal of performing the first open intrauterine surgery in Peru. We performed a successful intrauterine surgery at 25 weeks of gestation and a healthy infant was born by cesarean section at 37 weeks of gestation. We demonstrated the feasibility of this complex intrauterine surgery in our local setting.