1
artículo
Publicado 2017
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Con frecuencia se encuentran donantes de Banco de Sangre con presencia en suero del Anti-HBc total, en ausencia del Antígeno de superficie (HBsAg) y el anticuerpo contra el antígeno de superficie (Anti- HBs). Se diseñó el presente estudio para determinar la respuesta serológica a la vacunación contra el virus de la Hepatitis B y evaluar la efectividad de la vacuna en dichos casos, considerando que los títulos protectores en Hepatitis B se miden en niveles superiores a 10 mUI/ml. Se incluyeron 31 pacientes con el patrón serológico HBsAg(-)/Anti-HBs (-)/Anti-HBc (+). Se les administró 3 dosis de la vacuna ADN recombinante (Hepavax Gene 20 μg), siguiendo el esquema 0,1,2 meses. Se midieron los niveles de Anti-HBs 30 días después de la aplicación de la última dosis. Luego de las 3 dosis de vacuna, los niveles de Anti-HBs fueron > 100 mUI/ml en el 89%, > 500 en el 50% y &...
2
artículo
Publicado 2017
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Objetivos: Describir las características clínicas y bioquímicas en pacientes con histología compatible con esteatohepatitis del Hospital Nacional Arzobispo Loayza en el periodo 2010-2012. La frecuencia de esteatohepatitis alcohólica y no alcohólica, la presencia de síndrome metabólico y otros factores asociados a esteatohepatitis no alcohólica, sus principales indicaciones de biopsia hepática, y las características bioquímicas de acuerdo a la severidad del cuadro histológico. Materiales y métodos: Se evaluaron todas las biopsias hepáticas del período 2010-2012, se seleccionaron las muestras con diagnóstico de esteatohepatitis. Luego se revisaron sus respectivas historias clínicas. Resultados: 32 pacientes con esteatohepatitis cumplieron los criterios de inclusión, 28 fueron de sexo femenino y 4 masculino, cuya edad fue 49±12 años, 30 (94%) presentaba esteatohepatitis...
3
artículo
Publicado 2021
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Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT we...
4
artículo
Publicado 2021
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Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and...
5
artículo
Publicado 2023
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BACKGROUND & AIMS: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (e.g., Covid-19). This study aimed to investigate the association of genetic ancestry and race with acute-onchronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure and high risk of short-term death. METHODS: This prospective cohort study analyzed a comprehensive set of data including genetic ancestry and race, among several others, in 1274 patients with acutely decompensated cirrhosis (ADC) who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS: 395 (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4%...
