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artículo

Potentially hepatotoxic drugs are still being prescribed to liver disease patients under tertiary care: it is time to say enough

Publicado por
Dorelo, Rodrigo, Barcelos, Samantha T.A., Barros, Magela, Elustondo, Valeria, Pérez, Ysela Y.P., Oricchio, Martin, Uribe, Nelson D.S., Hernandez, Nelia, Joveleviths, Dvora, Alvares-da-Silva, Mario R.

Publicado 2021

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Introduction and aim: Drug-induced liver injury (DILI) manifests as a spectrum of clinical presentations that carries morbidity and mortality. Patients with chronic liver disease (CLD), particularly hospitalized, are at high risk for developing DILI. We aimed to investigate the use of potentially hepatotoxic drugs (PHD) in patients with CLD in a tertiary university hospital. Materials and methods: Adult (≥ 18 years-old) with CLD admitted to the hospital from January 2016 to December 2018 were evaluated regarding PHD, assessing the risk of DILI and liver enzymes behavior after exposure. Results: From 931 hospitalized patients with CLD, 291 (31.3%) were exposed to hepatotoxic drugs during their hospitalization. Of those, 244 (83.8%) were cirrhotic. The most frequent causes of liver disease were hepatitis C (41.2%), followed by alcohol (13.2%), hepatitis C/alcohol (11.7%) and non-alcoholi...

artículo

Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America

Publicado por
Farias, Alberto Queiroz, Vilalta, Anna Curto, Zitelli, Patrícia Momoyo, Pereira, Gustavo, Goncalves, Luciana L., Torre, Aldo, Diaz, Juan Manuel, Gadano, Adrian C., Mattos, Angelo Z., Mendes, Liliana S.C., Alvares-da-Silva, Mario R., Bittencourt, Paulo L., Benitez, Carlos, Couto, Claudia Alves, Mendizabal, Manuel, Toledo, Claudio L., Mazo, Daniel F., Barradas, Mauricio Castillo, Uson Raposo, Eva M., Padilla-Machaca, P. Martín, Lozano Miranda, Adelina Zarela, Malé-Velázquez, René, Lyra, André Castro, Dávalos-Moscol, Milagros B., Pérez Hernandez, Jose L, Ximenes, Rafael O., Silva, Giovanni Faria, Beltrán-Galvis, Oscar A., González Huezo, María S., Bessone, Fernando, Rocha, Tarciso D.S., Fassio, Eduardo, Terra, Carlos, Marín, Juan I., Casas, Patricia Sierra, Peña-Ramirez, Carlos de la, Parera, Ferran Aguilar, Fernandes, Flavia, da Penha Zago-Gomes, Maria, Méndez-Guerrero, Osvely, Marciano, Sebastián, Mattos, Angelo A., Oliveira, Joao C., Guerreiro, Gabriel T.S., Codes, Liana, Arrese, Marco, Nardelli, Mateus J., Silva, Marcelo O., Palma-Fernandez, Renato, Alcantara, Camila, Garrido, Cristina Sánchez, Trebicka, Jonel, Gustot, Thierry, Fernández, Javier, Clària, Joan, Jalan, Rajiv, Angeli, Paolo, Arroyo, Vicente, Moreau, Richard, Carrilho, Flair J.

Publicado 2023

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BACKGROUND & AIMS: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (e.g., Covid-19). This study aimed to investigate the association of genetic ancestry and race with acute-onchronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure and high risk of short-term death. METHODS: This prospective cohort study analyzed a comprehensive set of data including genetic ancestry and race, among several others, in 1274 patients with acutely decompensated cirrhosis (ADC) who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS: 395 (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4%...