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artículo

Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease

Publicado por
Arab, Juan Pablo, Dirchwolf, Melisa, Álvares-da-Silva, Mário Reis, Barrera, Francisco, Benítez, Carlos, Castellanos-Fernandez, Marlene, Castro-Narro, Graciela, Chavez-Tapia, Norberto, Chiodi, Daniela, Cotrim, Helma, Cusi, Kenneth, de Oliveira, Claudia Pinto Marques Souza, Díaz, Javier, Fassio, Eduardo, Gerona, Solange, Girala, Marco, Hernandez, Nelia, Marciano, Sebastián, Masson, Walter, Méndez-Sánchez, Nahum, Leite, Nathalie, Lozano, Adelina, Padilla, Martín, Panduro, Arturo, Paraná, Raymundo, Parise, Edison, Perez, Marlene, Poniachik, Jaime, Restrepo, Juan Carlos, Ruf, Andrés, Silva, Marcelo, Tagle, Martín, Tapias, Monica, Torres, Kenia, Vilar-Gomez, Eduardo, Costa Gil, José Eduardo, Gadano, Adrian, Arrese, Marco

Publicado 2020

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Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic F...

artículo

Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America

Publicado por
Farias, Alberto Queiroz, Vilalta, Anna Curto, Zitelli, Patrícia Momoyo, Pereira, Gustavo, Goncalves, Luciana L., Torre, Aldo, Diaz, Juan Manuel, Gadano, Adrian C., Mattos, Angelo Z., Mendes, Liliana S.C., Alvares-da-Silva, Mario R., Bittencourt, Paulo L., Benitez, Carlos, Couto, Claudia Alves, Mendizabal, Manuel, Toledo, Claudio L., Mazo, Daniel F., Barradas, Mauricio Castillo, Uson Raposo, Eva M., Padilla-Machaca, P. Martín, Lozano Miranda, Adelina Zarela, Malé-Velázquez, René, Lyra, André Castro, Dávalos-Moscol, Milagros B., Pérez Hernandez, Jose L, Ximenes, Rafael O., Silva, Giovanni Faria, Beltrán-Galvis, Oscar A., González Huezo, María S., Bessone, Fernando, Rocha, Tarciso D.S., Fassio, Eduardo, Terra, Carlos, Marín, Juan I., Casas, Patricia Sierra, Peña-Ramirez, Carlos de la, Parera, Ferran Aguilar, Fernandes, Flavia, da Penha Zago-Gomes, Maria, Méndez-Guerrero, Osvely, Marciano, Sebastián, Mattos, Angelo A., Oliveira, Joao C., Guerreiro, Gabriel T.S., Codes, Liana, Arrese, Marco, Nardelli, Mateus J., Silva, Marcelo O., Palma-Fernandez, Renato, Alcantara, Camila, Garrido, Cristina Sánchez, Trebicka, Jonel, Gustot, Thierry, Fernández, Javier, Clària, Joan, Jalan, Rajiv, Angeli, Paolo, Arroyo, Vicente, Moreau, Richard, Carrilho, Flair J.

Publicado 2023

Enlace

BACKGROUND & AIMS: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (e.g., Covid-19). This study aimed to investigate the association of genetic ancestry and race with acute-onchronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure and high risk of short-term death. METHODS: This prospective cohort study analyzed a comprehensive set of data including genetic ancestry and race, among several others, in 1274 patients with acutely decompensated cirrhosis (ADC) who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS: 395 (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4%...