Los rizomas de Curcuma longa recolectados en la localidad de Pucallpa por extracción etanólica en frío, producen por lo menos tres curcuminoides coloreados estimados mediante cromatografía en capa fina y cromatografía líquida de alta performance HPLC (Fig. 1). Cada colorante ha sido aislado mediante cromatografía en columna y las estructuras analizadas por espectroscopía IR (Fig. 2). El modelo de estructura de la curcumina y los curcuminoides similar a los carotenoides hace suponer que las insaturaciones pueden absorber oxígeno y radicales libres, además de implicar un mecanismo antiinflamatorio (Fig. 3).En conexión con los trabajos de MISRA y col (1972) acerca de la comparación de la actividad antiradicálica de la enzima superóxido dismutasa correlacionada con la oxidación o autooxidación de la epinefrina; y el trabajo de SREEJAYAN y col (1997) que utiliza el óxido nít...

A Study of the chemical composition of the essential oil of Minthostachys mollis (Kunth) Griseb, has been done by means of chromatographic and spectronic methods, in order to determine the composition according to the place of selling. We found the following: in the essential oil from Tarma (Junín, región A. A. Cáceres): l-tetradecene (23,14%), 2S-transmenthona (23,00%) and pulegone (13,21%), in the essential oil from Huaraz (Ancash. Región Chavín): 2S-trans-menthona (41,48%), pulegone (16,02%), y - terpinen (7,55%) and in case of essential oil from Pampas (Huancavelica, región Los Libertadores Wari): 2S-trans-menthona (34,51 %), pulegone (28,62%), and nerolidol (5,08%).

The leaves of Lupinus C.P. Smith were colected from the highlands in Lima, it contains among other 5 flavonoids and 5 alkaloids.The flavonoid genistein was characterized by means of visible-UV spectroscopy, observing the bathochromic and hipsochomic movements of the spectra with sodium methoxide, aluminuin chloride, boric acid and sodium acetate reagents.The IR spectrum reveals the presence of the alkaloid lupenin or hydroxylupenin.Both the flavonoid and the alkaloid show a strong antibacterial activity and the alkaloid shows in addition of this property an antifungic activity.

A Study of the chemical composition of the essential oil of Minthostachys mollis (Kunth) Griseb, has been done by means of chromatographic and spectronic methods, in order to determine the composition according to the place of selling. We found the following: in the essential oil from Tarma (Junín, región A. A. Cáceres): l-tetradecene (23,14%), 2S-transmenthona (23,00%) and pulegone (13,21%), in the essential oil from Huaraz (Ancash. Región Chavín): 2S-trans-menthona (41,48%), pulegone (16,02%), y - terpinen (7,55%) and in case of essential oil from Pampas (Huancavelica, región Los Libertadores Wari): 2S-trans-menthona (34,51 %), pulegone (28,62%), and nerolidol (5,08%).

The leaves of Lupinus C.P. Smith were colected from the highlands in Lima, it contains among other 5 flavonoids and 5 alkaloids.The flavonoid genistein was characterized by means of visible-UV spectroscopy, observing the bathochromic and hipsochomic movements of the spectra with sodium methoxide, aluminuin chloride, boric acid and sodium acetate reagents.The IR spectrum reveals the presence of the alkaloid lupenin or hydroxylupenin.Both the flavonoid and the alkaloid show a strong antibacterial activity and the alkaloid shows in addition of this property an antifungic activity.

Los rizomas de Curcuma longa recolectados en la localidad de Pucallpa por extracción etanólica en frío, producen por lo menos tres curcuminoides coloreados estimados mediante cromatografía en capa fina y cromatografía líquida de alta performance HPLC (Fig. 1). Cada colorante ha sido aislado mediante cromatografía en columna y las estructuras analizadas por espectroscopía IR (Fig. 2). El modelo de estructura de la curcumina y los curcuminoides similar a los carotenoides hace suponer que las insaturaciones pueden absorber oxígeno y radicales libres, además de implicar un mecanismo antiinflamatorio (Fig. 3).En conexión con los trabajos de MISRA y col (1972) acerca de la comparación de la actividad antiradicálica de la enzima superóxido dismutasa correlacionada con la oxidación o autooxidación de la epinefrina; y el trabajo de SREEJAYAN y col (1997) que utiliza el óxido nít...

Se diseñó y formuló un champú conteniendo el extracto alcohólico de Urtica urens L. utilizando un método analítico, experimental y comparativo. Se utilizó las hojas de la planta (Formulación champú) y conejos blancos, raza neozelandesa machos (Ensayo irritación para evaluación biológica de productos sanitarios). Formaron parte del presente estudio personas diagnosticadas con caída del cabello de origen no patológico, en número de 10 personas que fueron evaluados por un profesional médico, por espacio de 21 días. Se sometieron a observación microscópica los cabellos caídos a diario para evaluar si existe aumento del diámetro del cabello comparándolos al inicio y al final del estudio. Se obtuvo el recuento de cabellos caídos por día durante todo el tratamiento. Utilizando el método de recuento de cabellos estandarizado por 60 segundos. Se obtuvieron como resultado...

The purpose of this research has been to iso late and identify the alkaloids from the leaves of Ruta graveolens L., and to relate their chemical structure with the mutagenic activity of the leaves, which was demonstrated in a previous report. It were isolated four alkaloids named "A", "1 ", "2" and "3" which were structurally elucidated by their melting point, chemical reactions and by UV and IR spectroscopy. The alkaloid "A" was identified as acridone alkaloid, and the alkaloid "1" and "2" were identified as furoquinoline alkaloids. The remaining one, alkaloid "3" was considered as quinolone alkaloid. Due to its high amount and chemical structure, the alkaloid "A" was considered as the main responsible of the mutagenic activity of the leaves of Ruta graveolens L., while alkaloids "1" and "2" probably do not participate in the mutagenicity of the extract owing to their amount. Finally, t...

The purpose of this research has been to iso late and identify the alkaloids from the leaves of Ruta graveolens L., and to relate their chemical structure with the mutagenic activity of the leaves, which was demonstrated in a previous report. It were isolated four alkaloids named "A", "1 ", "2" and "3" which were structurally elucidated by their melting point, chemical reactions and by UV and IR spectroscopy. The alkaloid "A" was identified as acridone alkaloid, and the alkaloid "1" and "2" were identified as furoquinoline alkaloids. The remaining one, alkaloid "3" was considered as quinolone alkaloid. Due to its high amount and chemical structure, the alkaloid "A" was considered as the main responsible of the mutagenic activity of the leaves of Ruta graveolens L., while alkaloids "1" and "2" probably do not participate in the mutagenicity of the extract owing to their amount. Finally, t...

Los fucoidanos aislados y purificados del alga parda Lessonia trabeculata, mediante precipitaciones sucesivas con etanol 96º y complejamiento con cloruro de cetilpiridinio, fueron sometidos a irradiación gamma a dosis de 10, 30, 50 y 100 KGy en un irradiador modelo Gammacel 220 con fuente de Co-60, para obtener los polisacáridos sulfatados de bajo peso molecular y evaluar su efecto anticoagulante. Hay disminución de la viscosidad, conforme aumenta la dosis irradiativa del fucoidano, mientras la electroforesis en agarosa, evidencia la disminución de sus pesos moleculares en relación a la movilidad electroforética. Los fucoidanos mostraron notable actividad anticoagulante frente a la prueba TTPa, que evalúa la vía intrínseca; se seleccionó esta ruta para la evaluación de la prueba de inhibición de la generación de trombina; para la concentración de 10 mg/mL se observó que e...

Objectives: To determine the chemical composition of the essential oil of Aloysia triphylla “Cedrón”, obtained from the leaves and stems by the steam entrainment method, which in turn serves as an input for the preparation of a mouthwash that can combat halitosis. Materials and methods: The plant material was collected from the city of Huaraz and dried to the environment, the extraction of the essential oil was carried out by the hydrodistillation method with steam drag at controlled temperature and pressure, it was stored in a jar of amber glass in refrigeration. The yield was determined by the volumetric gravimetric method. The determination of the chemical components was carried out by the method of gas chromatography coupled to mass spectrometry using an Agilent Technologies 7890 gas chromatograph, Agilent Technologies 5975C mass spectrometer detector, Column J&W 122-1545.67...

Objectives: to determine the antimicrobial activity of the essential oil obtained from the leaves and stems of Aloysia triphylla “Cedrón” from the city of Huaraz, department of Ancash, district of Mancos. Materials and methods: The method of hydrodistillation by dragging of Steam to obtain the essential oil and for the determination of the antibacterial activity was carried out by the agar diffusion methodology against Streptococcus mutans ATCC 25175 and Porphyromonas gingivalis ATCC 33277, comparing them with a positive control which was a commercial chlorhexidine mouthwash at 0.05%. Results: a yield of 0.11 was obtained and in the microbiological study, 21.3 mm halos of the essential oil and 19.9 mm of the positive control against Streptococcus mutans ATCC 25175 and 35.5 mm in the essential oil were obtained. and 25.4 mm of the positive control against Porphyromonas gingivalis ATC...

Las películas comestibles con fines de empaquetamiento y reemplazo del material plástico son producidas a base de materias primas biodegradables como polisacáridos y agentes con propiedades biológicas, haciendo que el producto final se constituya en una alternativa para la protección y extensión de la vida útil de alimentos. La presente investigación tuvo como objetivo central evaluar la actividad antioxidante y antimicrobiana de biopelículas de quitosano funcionalizadas con aceite esencial de muña. Para tal fin se formularon 12 biopelículas con 3 concentraciones de quitosano (1, 2 y 3%) y 3 de aceite esencial (0.5, 2 y 5%) incluyendo blancos de solo quitosano. La actividad antioxidante evaluada en biopelículas con mayor contenido de aceite esencial de muña presenta más del 60% de captación de radical libre DPPH, mientras en la actividad antimicrobiana evaluada por placas ...

Objective: To evaluate the inhibitory potential of the α-amylase and α-glucosidase enzymes, as well as the inhibition of glucose diffusion, using polysaccharides isolated from Nostoc sphaericum Vaucher ex Bornet & Flahault and treated by in vitro simulated gastrointestinal digestion. Materials and methods: The polysaccharides obtained from the microalga were purified and treated through in vitro gastrointestinal digestibility in order to simulate digestion. The hypoglycemic activity was evaluated by methods such as the inhibition of α-glucosidase and α-amylase, and glucose diffusion of the digested polysaccharides, and compared with the medication acarbose. Results: The results showed that the concentration of 50 mg/mL of digested polysaccharides decreases by 85.26 % the spread of in vitro glucose. The inhibitory concentration (IC50) of the α-glucosidase enzyme was 314.23 ...