Realiza un estudio basado en los tallos de la especie Dracontium loretense Krause de la familia aráceas. El material fue recolectado de acuerdo a las indicaciones etnobotánicas en la ciudad de Iquitos-Loreto. Efectúa la determinación taxonómica hasta llegar a su identificación y realiza un estudio morfológico e histológico. Realiza ensayos preliminares sobre tallos a los cuales aplica método de Dragendorff, método fitoquímico simplificado y método fitoquímico modificado. Analiza su composición química para confirmar la presencia de los principios activos a los cuales se les atribuye la acción farmacológica, como cafetaninos, glicósidos fenólicos y los esteroides. Encuentra principalmente cafetaninos, con el cual desarrolla ensayos farmacológicos y microbiológicos para confirmar la razón de su uso en medicina tradicional.

The aguaymanto is a native species of the Peruvian highland, which has a tiny fruit that disagrees with its greatness and nutritional therapy. The present investigation had as objetive to assess and compare the total polyphenol content by the Folin-Ciocalteu method and antioxidant capacity of the fruits of Physalis peruviana L., from Huánuco, Junín, Ancash y Cajamarca by the method of the DPPH (1,1-diphenyl-2-picril-hidrazilo). The fruit coming from Huánuco presented a higher content of phenolic compounds expressed as 149.3 ± 1.62 mg/Eq of gallic acid/100g fruit. In addition, greater antioxidant capacity obtaining as inhibitory concentration IC50 1.86 mg/mL, compared with the fruits from Junín, Ancash y Cajamarca; and it would be a good source of consumption in benefit for the health.

Juglans neotropica Diels "peruvian walnut" is a tree that grows in jungle, in areas ofmontane and montane rain forest whose leaves have antioxidant, astringent, antibacterial andantiseptic properties. The objective was to determine the antioxidant activity of a standardizedhydroalcoholic extract of Juglans neotropica Diels leaves. Leaves from Huandoval district,Pallasca province, Ancash Region were used. Standardization analysis included determinationof moisture, physicochemical parameters, solubility march, phytochemical screening, andthin layer chromatography; antioxidant activity was determined by the DPPH inhibitionassay. In phytochemical screening there was a greater concentration of phenolic compoundsand antioxidant activity was at 25 and 35 μg/mL respectively, with an IC 50 of 12.82 μg/mL.In conclusion, the standardized hydroalcoholic extract from Juglans neotropica Diels leaves...

La investigación tuvo como objetivo evaluar la eficacia del extracto etanólico del fruto de Passiflora edulis Sims (maracuyá) sobre el nivel de glicemia en ratas aloxanizadas. El fruto de maracuyá fue recolectado en el valle de Chanchamayo, La Merced Junín-Perú; Para la evaluación del efecto hipoglicemiante se siguió el modelo según Kameswara Rao et al., 1999; donde se utilizaron 36 ratas albinas que fueron adquiridas del Instituto Nacional de Salud y se dividieron aleatoriamente en grupos de 6 ratas cada uno, donde el 1° grupo recibió Aloxano 130 mg/Kg (A) el 2° (A) + Insulina 4 UI/Kg, el 3° (A) + Glibenclamida 5 mg/Kg, y grupos 4°, 5° y 6° recibieron extracto a 50, 100 y 200 mg/kg respectivamente; se extrajo sangre para medir la glicemia (mg/dL) a tiempo 0, 48, 50, 52, 96 y 98 horas después de las administraciones. Los datos se evaluaron mediante técnicas multivariada...

Objective: To determine the antibacterial, in vitro activity of ethanolic extract of Caesalpinia spinosa (Tara), on the oral biofilm bacteria cultures. Material and methods: An in vitro experimental study was carried out, in which the antibacterial activity of an ethanolic extract of C. spinosa and the controls (chlorhexidine 0.12%, oral antiseptic (OA), ethanol and distilled water), were compared to strain cultures strains of Streptococcus mutans (ATCC® 25175), Streptococcus sanguinis (ATCC® 10556), Enterococcus faecalis (ATCC® 29212), Staphylococcus aureus (ATCC® 6538) and Porphyromonas gingivalis (ATCC® 30277). The agar diffusion method with 6 mm diameter wells was used, with the experimental group and controls Results: It was evident that the average of the inhibition zone formed by the application of the ethanolic extract of C. spinosa on S. aureus was much larger than the one ...

Objective: To evaluate the antimicrobial activity, through the agar diffusion method with wells, of camu camu (CC) against oral microorganisms. Methods: Strains of S. aureus, S. mutans, C. albicans and P. gingivalis were inoculated in Petri dishes. Ethanolic extracts (EEs) of peel, pulp and CC seed and controls (0.12% chlorhexidine, oral antiseptic, 70° alcohol and distilled water) were loaded into 6 mm diameter wells. All plates were incubated for 24-48 h and 11 days (P. gingivalis) at 35°C and the antimicrobial activity was determined by the formation of a zone of microbial growth inhibition (ZMGI), around the wells and measured by a Vernier caliper, by a researcher, calibrated interexaminer. The average of the different ZMGI areas (mm) was determined. The experiment was executed between 3 and 14 replicas. Descriptive and inferential statistics were applied (p<0.05). Results: Seed...

Objective: To evaluate the inhibitory potential of the α-amylase and α-glucosidase enzymes, as well as the inhibition of glucose diffusion, using polysaccharides isolated from Nostoc sphaericum Vaucher ex Bornet & Flahault and treated by in vitro simulated gastrointestinal digestion. Materials and methods: The polysaccharides obtained from the microalga were purified and treated through in vitro gastrointestinal digestibility in order to simulate digestion. The hypoglycemic activity was evaluated by methods such as the inhibition of α-glucosidase and α-amylase, and glucose diffusion of the digested polysaccharides, and compared with the medication acarbose. Results: The results showed that the concentration of 50 mg/mL of digested polysaccharides decreases by 85.26 % the spread of in vitro glucose. The inhibitory concentration (IC50) of the α-glucosidase enzyme was 314.23 ...

La investigación tuvo como objetivo evaluar la eficacia y seguridad de supositorios de aceite de Copaifera officinalis L. “copaiba” en pacientes con diagnóstico definitivo de crisis hemorroidal aguda. El ensayo fue clínico prospectivo, controlado, comparativo, aleatorio y se realizó en el Instituto de Investigaciones Clínicas de la Facultad de Medicina de UNMSM. y Servicio de Gastroenterología del Hospital Nacional Dos de Mayo. Los pacientes evaluados presentaban diagnóstico definitivo de crisis hemorroidal aguda. El diagnóstico se realizó mediante estudio clínico y proctoscópico antes y después del tratamiento, además de exámenes auxiliares serológicos; 60 pacientes fueron enrolados voluntariamente al protocolo cumpliendo con los criterios éticos de investigación; los cuales fueron distribuidos en 3 grupos de 20 casos cada uno, administrándoseles supositorios de co...