Toxemia - Other mechanisms, predictive and diagnostic tests, local experiences

Introduction: Bidens pilosa species belonging to the Asteraceae family, known in Peru as love dry bur, is credited with anti-inflammatory, diuretic, hepatoprotective effects. Objectives: To determine the protective effect of phenolic compounds and flavonoids extracted from Bidens pilosa L whole plant on breast cancer induced in rats by 7,12-dimethylbenz (A) anthracene (DMBA). Design: Experimental. Setting: Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Bidens pilosa L whole plant collected in Santiago de Cao, Ascope, La Libertad, and female rats. Interventions: Phenolic compounds and flavonoids were obtained by rapid column chromatography with solvents of increasing polarity; by thin layer chromatography on a preparative scale four phenolic compounds were isolated and elucidated by UV-Visible spectroscopy with s...

651 pregnant women at 26 to 36 weeks gestation were tested 1 hour with 50 g oral load of glucose (Test 50 g). They are passing the threshold of greater than or equal 130 mg / dl in plasma were suspicious of Gestational Diabetes (SDG). You're were subsequently tested oral glucose tolerance (OGTT) stop the diagnosis of gestational diabetes mellitus (BG) according to the criteria of the National Diabetes Data Group. The age of pregnant women was 26.3 ± 6.4 years (mean ± SD), range 16-45 years. 310 pregnant women (47.6%) did not have any risk factors for diabetes mellitus. 57 pregnant women (8.7%) were SDG. 32 (4.9%) underwent OGTT, resulting DG 24 patients (3.7%). There was no significant difference in the incidence of BG in people with risk factors and those that had not. The sensitivity of the test was 50 g of 88.9% and specificity of 95.2%. There were 3 DG not detected by the test; so ...

OBJECTIVES: To determine pregnancy complicated by arterial hypertension pathogenic factors. DESIGN: Retrospective clinical study. SETTING: Hospital Nacional Docente Madre-Niño San Bartolome, Lima.PARTICIPANTS: Women with pregnancies complicated by arterial hypertension. INTERVENTIONS: The hospital’s perinatal information technology system was reviewed from January 1991 through December 2006 in order to determine the prevalence of pregnancies complicated by arterial hypertension, to establish associated factors and describe its natural history. MAIN OUTCOME MEASURES: Pregnancy arterial hypertension prevalence and conditioning factors. RESULTS: Pregnancy arterial hypertension prevalence was 8,6% (8 506/98 956). Preeclampsia and eclampsia represented 95% (8 085/8 506) of these cases, preeclampsia prevalence was 8,5% and eclampsia, 0,11%. Preeclampsia and eclampsia conditioning factors we...

OBJECTIVES: To determine pregnancy complicated by arterial hypertension pathogenic factors. DESIGN: Retrospective clinical study. SETTING: Hospital Nacional Docente Madre-Niño San Bartolome, Lima.PARTICIPANTS: Women with pregnancies complicated by arterial hypertension. INTERVENTIONS: The hospital’s perinatal information technology system was reviewed from January 1991 through December 2006 in order to determine the prevalence of pregnancies complicated by arterial hypertension, to establish associated factors and describe its natural history. MAIN OUTCOME MEASURES: Pregnancy arterial hypertension prevalence and conditioning factors. RESULTS: Pregnancy arterial hypertension prevalence was 8,6% (8 506/98 956). Preeclampsia and eclampsia represented 95% (8 085/8 506) of these cases, preeclampsia prevalence was 8,5% and eclampsia, 0,11%. Preeclampsia and eclampsia conditioning factors we...

Objectives: To determine whether oral administration of Mimosa pudica (mimosa) leaves ethanol extract modifies fertility in normal rats. Design: Experimental study. Setting: Instituto de Investigaciones Clinicas, Facultad de Medicina, Facultad de Farmacia, Universidad Nacional Mayor de San Marcos, Hospital Nacional Hipolito Unanue, Lima, Peru. Biological material: Albino rats and Mimosa pudica leaves. Methods: Forty-eight animals were divided randomly into groups of six animals each. The first was control and received saline solution 5 mL/kg and the others 50, 250 and 500 mg/kg oral extracts for 28 days. Each group considered 6 males and 6 females together. The animals were killed to observe the presence of fetuses in uterus. FSH, estradiol and progesterone levels were determined in μg /dL in female rats’ blood samples and hormone dosage was done by electrochemoluminiscence method. In...

Objective: To determine whether oral administration of the ethanolic flower extract from Laccopetalum giganteum (pacra-pacra) increases fertility in normal rats. Design: Experimental study. Setting: Faculty of Medicine and Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos. Biologic material: Rats. Interventions: Forty-eight rats were randomly distributed into 2 groups of 24 rats each. The first control group received solución salina fisiológica (SSF) 5 mL/kg and the second group 300 mg/kg of the extract, orally, for 15 days. Each group had 6 female rats and 6 male rats living together and 6 female rats and 6 male rats lived separate. The animals living together were sacrificed in order to observe the fetuses in the uterus. The animals that lived separate had blood samples taken in order to determine testosterone levels in male rats and LH, FSH, estrogen and...