Obejetive: To identify the etiopathogenic factors associated to both fetal and neonatal deaths in Lima, Peru. Materials and methods: Retrospective study of all the cases of fetal death over 20 weeks gestation and neonatal death before 28 days of life that underwent autopsy and histopathologic study, in order to identify the cause of perinatal death. Settings: Hospital San Bartolomé in Lima, between January 1, 1996 and December 31, 2000. Results: The prevalence of fetal death was 1,68% (508/30125) and neonatal death 1,44% (434/30125). All fetal deaths and 58,8% (255/434) of the neonatal deaths underwent autopsy. Among 508 fetal deaths, 92 (18%) presented signs of autolysis that did not allow appropiate identification of the etiopathogenic process. Fetal death was associated to prematurity (60,5%), nutricional/vascular defect (78,1%), social privation (60,8%), congenital anomaly (14,6%) a...

OBJECTIVE: To determine the consequences of asymptomatic bacteriuria. MATERIAL AND METHODS: Prospective, comparative study of 3,602 pregnant women belonging to the Epidemiologic Surveillance Program of Glucose Intolerance in the Woman and Infant at San Bartolomé Hospital, Lima, from june 1990 through December 1994. RESULTS: 720 (20%) presented significant bacteriuria. From other 1.432 selected pregnant females without urinary symptom and with prenatal control, 304 (21,1) presented aymptomatic bacteriuria. Compared with the general pregnant population, asyimptomatic bacteriuria was three times more frequent inpregnant women that had of urinary tract infection before current gestation. Compared with non bacteriuric pregnant females, those with bacteriuria presented significant ferropenic anemia, arterial hipertension, premature rupture ofmembranes, pretem delivery, perineal condiloma peri...

Objective: To ascertain that social and emotional deprivation of the mother is associated with fetal growth restriction, fetal death, preterm birth and congenital defects. Materials and Methods: We retrieved the maternal and perinatal outcome from the Informatic Perinatal System of all pregnancies with antenatal care whose delivery occurred between January 1, 1992 and December 31, 2001. Three groups of patients with social and emotional deprivation were included: 1) single women (n=1285), 2) teenage women with absent prenatal care (APC), (n=2131), and 3) primigravid with stature lower than 160 cm (n=35722). Maternal and perinatal outcome were compared with: 1) women living with sexual partner (n=5550), 2) teenage women with prenatal care (n=7644), and 3) primigravids taller than 159 cm (n=5264). Odds ratio and 95% confidence interval (CI) were calculated. Results: Single women presented ...

OBJECTIVES: To determine pregnancy complicated by arterial hypertension pathogenic factors. DESIGN: Retrospective clinical study. SETTING: Hospital Nacional Docente Madre-Niño San Bartolome, Lima.PARTICIPANTS: Women with pregnancies complicated by arterial hypertension. INTERVENTIONS: The hospital’s perinatal information technology system was reviewed from January 1991 through December 2006 in order to determine the prevalence of pregnancies complicated by arterial hypertension, to establish associated factors and describe its natural history. MAIN OUTCOME MEASURES: Pregnancy arterial hypertension prevalence and conditioning factors. RESULTS: Pregnancy arterial hypertension prevalence was 8,6% (8 506/98 956). Preeclampsia and eclampsia represented 95% (8 085/8 506) of these cases, preeclampsia prevalence was 8,5% and eclampsia, 0,11%. Preeclampsia and eclampsia conditioning factors we...

During normal pregnancy, the cytotrophoblast becomes their epithelial phenotype to endothelial phenotype (termed pseudo-vasculogenesis) and invade the maternal spiral arteries. This physiological transformation myometrial spiral arteries increases blood flow and nutrient supply to the fetus at the end of the first quarter. Vascular, such as vascular endothelial growth factor (VEGF), placental growth factor (PIGF), the tyrosine kinase-1 soluble fms-like receptor (sFlt1) factors involved in this process. At the origin of circulating angiogenic proteins involved preeclampsia. Furthermore, serum from women with preeclampsia reduced the viability of the trophoblast, which is related to changes in the sensitivity of trophoblast to Fas-mediated apoptosis, which could be mediated by proinflammatory cytokines, which have been found increased in patients with preeclampsia. In preeclompsia, there i...

During normal pregnancy, the cytotrophoblast becomes their epithelial phenotype to endothelial phenotype (termed pseudo-vasculogenesis) and invade the maternal spiral arteries. This physiological transformation myometrial spiral arteries increases blood flow and nutrient supply to the fetus at the end of the first quarter. Vascular, such as vascular endothelial growth factor (VEGF), placental growth factor (PIGF), the tyrosine kinase-1 soluble fms-like receptor (sFlt1) factors involved in this process. At the origin of circulating angiogenic proteins involved preeclampsia. Furthermore, serum from women with preeclampsia reduced the viability of the trophoblast, which is related to changes in the sensitivity of trophoblast to Fas-mediated apoptosis, which could be mediated by proinflammatory cytokines, which have been found increased in patients with preeclampsia. In preeclompsia, there i...

OBJECTIVES: To determine pregnancy complicated by arterial hypertension pathogenic factors. DESIGN: Retrospective clinical study. SETTING: Hospital Nacional Docente Madre-Niño San Bartolome, Lima.PARTICIPANTS: Women with pregnancies complicated by arterial hypertension. INTERVENTIONS: The hospital’s perinatal information technology system was reviewed from January 1991 through December 2006 in order to determine the prevalence of pregnancies complicated by arterial hypertension, to establish associated factors and describe its natural history. MAIN OUTCOME MEASURES: Pregnancy arterial hypertension prevalence and conditioning factors. RESULTS: Pregnancy arterial hypertension prevalence was 8,6% (8 506/98 956). Preeclampsia and eclampsia represented 95% (8 085/8 506) of these cases, preeclampsia prevalence was 8,5% and eclampsia, 0,11%. Preeclampsia and eclampsia conditioning factors we...