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artículo

Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest

Publicado por
Paul S., Zhang A., Ludeña Y., Villena G.K., Yu F., Sherman D.H., Gutiérrez-Correa M.

Publicado 2017

Enlace

Here, we report the complete genome sequence of a high alkaline cellulase producing Aspergillus fumigatus strain LMB-35Aa isolated from soil of Peruvian Amazon rainforest. The genome is ∼27.5 mb in size, comprises of 228 scaffolds with an average GC content of 50%, and is predicted to contain a total of 8660 protein-coding genes. Of which, 6156 are with known function; it codes for 607 putative CAZymes families potentially involved in carbohydrate metabolism. Several important cellulose degrading genes, such as endoglucanase A, endoglucanase B, endoglucanase D and beta-glucosidase, are also identified. The genome of A. fumigatus strain LMB-35Aa represents the first whole sequenced genome of non-clinical, high cellulase producing A. fumigatus strain isolated from forest soil.

artículo

Development of the pediatric neuro-oncology services assessment aid: An assessment tool for pediatric neuro-oncology service delivery capacity

Publicado por
Rajagopal, R, Coronado, RD, Hamid, SA, Martin, del, Campo, RN, Boop, F, Bag, A, Reséndiz, AEB, Vasudeva, Bhat, K, Campos, D, Chang, K, Cirt, R, Rahmartani, LD, Foo, JC, Hoveyan, J, Lucas, JT,, Jr, Ngcana, T, Ul, Ain, R, Omran, N, Osorio, DS, Qureshi, BM, Sabin, ND, Schandorf, E, Bankah, P, Dadzie, M-A, Gbadamos, H, Sharafeldin, H, Somathilaka, M, Yang, P, Jean-Jacques, YA, Zhang, A, Salman, Z, Gonzalez, M, Friedrich, P, Rodriguez-Galindo, C, Qaddoumi, I, Moreira, DC

Publicado 2024

Enlace

Background. To enhance the quality of care available for children with central nervous system (CNS) tumors across the world, a systematic evaluation of capacity is needed to identify gaps and prioritize interventions.To that end, we created the pediatric neuro-oncology (PNO) resource assessment aid (PANORAMA) tool. Methods. The development of PANORAMA encompassed 3 phases: operationalization, consensus building, and piloting. PANORAMA aimed to capture the elements of the PNO care continuum through domains with weighted assessments reflecting their importance. Responses were ordinally scored to reflect the level of satisfaction. PANORAMA was revised based on feedback at various phases to improve its relevance, usability, and clarity. Results. The operationalization phase identified 14 domains by using 252 questions.The consensus phase involved 15 experts (6 pediatric oncologists, 3 radiat...