1
artículo
Publicado 2024
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Escherichia coli es una enterobacteria que forma parte del microbioma intestinal de los mamíferos y es capaz de causar diversas enfermedades, especialmente en poblaciones vulnerables. Adicionalmente, la emergencia de variantes de E.coli resistentes a los antibióticos supone una creciente amenaza global para la salud pública. Esta resistencia, usualmente codificada por múltiples genes, que codifican para la expresión de enzimas, proteínas de membrana, porinas, bombas de flujo o mutaciones de la molécula diana. Investigaciones recientes han reportado mutaciones específicas asociadas a resistencia, como qnr, pmrB, glpT, y la variante blaTEM (C32T). El objetivo de este estudio fue identificar la frecuencia de mutaciones cromosómicas que otorgan resistencia antibiótica en genomas de E. coli provenientes de niños en el distrito de Villa El Salvador en Lima, Perú. Un total de 19 ge...
2
artículo
Publicado 2022
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“Mycobacterium gordonae is a nontuberculous mycobacterium found in diverse environments and is considered an opportunistic pathogen in immunocompromised patients. We report the draft genome sequence of a Mycobacterium gordonae strain isolated from a free-living amoeba found in a nosocomial environment in Lima, Peru.“
3
artículo
Publicado 2022
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“Mycobacterium gordonae is a nontuberculous mycobacterium found in diverse environments and is considered an opportunistic pathogen in immunocompromised patients. We report the draft genome sequence of a Mycobacterium gordonae strain isolated from a free-living amoeba found in a nosocomial environment in Lima, Peru.“
4
artículo
Background: Peru recorded one of the world’s highest COVID-19 mortality rates, with nearly 4.5 million reported cases and 220,000 deaths by March 2024. Understanding the emergence and spread of SARS-CoV-2 variants in this context is key to informing effective public health responses. This study describes the genomic diversity, transmission dynamics, and geographic spread of SARS-CoV-2 in Peru from 2020 to 2024. Methods: We analyzed nearly 50,000 high-quality public SARS-CoV-2 genome sequences collected nationwide between March 2020 and March 2024. Phylogeographic and mutational analyses were performed to identify variant lineages, trace their origins, and map viral movements within and beyond Peru. Results: We show that Peru’s epidemic waves were shaped by the emergence of locally evolved variants, including Lambda (C.37), Gamma (P.1.12), and Omicron (XBB.2.6 and DJ.1) sub-lineages. ...
