Mediante la simulación con el método de Monte Carlo se realizó una descripción atomística de la estructura y procesos de ordenación en el sistema Cu-Au en un modelo bidimensional. El modelo ABV de la aleación es un sistema de N átomos A y B, situados en los sitios de una red rígida con algunos sitios vacantes. En el modelo se asume la interacción par a primeros vecinos con una energía de ordenación constante J = 0.03 eV. La dinámica fue introducida por medio de una vacancia que intercambia de lugar con los átomos vecinos más próximos. Las simulaciones fueron realizadas en una red cuadrada con 1024 y 4096 partículas, usando condiciones de frontera periódicas para evitar efectos de borde. Fueron calculados los dos primeros parámetros de corto alcance de Warren–Cowley como función de la concentración y temperatura. También se estudió las probabilidades de formación...

On the base of the application of multielemental analytic methods of characterization of organic samples, such as the fluorescence of X-rays, neutron activation analysis and Coleman chemical analysis, the possibility of use of several parts of the plant named Quinua, Chenopodium quinoa Willd is suggested as alternative natural fertilizer for this crop.

Adolescence is a fundamental stage in identity formation. This study examines how different dimensions of the school climate influence the development of self-concept among Peruvian adolescents, all within the bioecological framework proposed by Bronfenbrenner. Using a cross-sectional correlational design, 224 students (50% female, 50% male; M=15.42 years) from a public school in northern Peru were evaluated in 2025. The School Climate Scale, the Garley Self-Concept Questionnaire, and a sociodemographic questionnaire were administered. A paradox was identified: a moderately adequate school climate (M=50.98±3.64) coexists with low levels of self-concept (M=123.87±20.56), particularly in the physical and intellectual dimensions. A negative correlation was observed between school climate stability and intellectual self-concept (r=-0.206, p<0.002), suggesting that overly structured environ...

Introducción. Las enfermedades cardiovasculares son unas de las comorbilidades más reportadas en los casos de COVID-19. Objetivo. Evaluar la asociación entre la presencia de enfermedades cardiovasculares y muerte por COVID-19 en una cohorte de pacientes hospitalizados en el departamento de Cajamarca, durante el año 2020. Métodos. Cohorte retrospectiva de 576 pacientes hospitalizados por COVID-19 entre julio y diciembre del 2020, provenientes de cuatro hospitales de Cajamarca. Se realizó un análisis de sobrevida mediante regresión de Cox para establecer la asociación entre la muerte por COVID-19 y la presencia de hipertensión arterial (HTA), diabetes tipo 2, obesidad y multimorbilidad, mediante modelos ajustados por factores sociodemográficos y clínicos buscando identificar posibles variables modificadoras de efecto. Resultados. La mortalidad por COVID-19 fue de 45,1%. En el a...

AIM:To investigate clinicopathological features and biomarkers of BC tumors in males and their prognostic value in Peruvian population. METHODS: This study looked at a single-institution series of 54 Peruvian males with invasive BC who were diagnosed from Jan 2004 to June 2018. Standard pathological features, TIL levels, MMR proteins, AR immunohistochemistry staining, and PIK3CA gene mutations were prospectively evaluated in cases with available paraffin material. Percentage of AR and estrogen receptor (ER) positive cells was additionally calculated by software after slide scanning. Statistical analyses included association tests, intraclass correlation test and Kaplan Meier overall survival curves. RESULTS: The median age was 63 years and most cases were ER-positive (85.7%), HER2 negative (87.2%), Luminal-A phenotype (60%) and clinical stage II (41.5%) among our male breast tumors. Medi...

Objective: To evaluate the frequency distribution of viral infections in Peruvian Breast Cancer (BC) lesions and its association with clinicopathological features. Additionally, a prospective evaluation of p16 and Tumor-infiltrating lymphocytes (TIL) levels were performed for developing a comprehensive analysis. Methods: Detection of high risk- human papillomavirus (HR- HPV) through qPCR was performed in 447 BC and 79 non-cancer frozen samples. Paired paraffin samples from 238 BC were stained with Human cytomegalovirus (HCMV) and p16 immunohistochemistry. TIL was calculated in 397 BC cases. Results: HCMV was positive in 72.5%. HR- HPV was detected in 2.9% of BC and 1.3% of non-malignant samples. P16+ was found in 28.15% and median TIL percentage was 30. HR- HPV infection was associated with non-ductal histology (p=0.003) and p16+ (p=0.017). Positive P16+ was associated with higher T stag...

Objective: To evaluate the relationship between circulating tumor DNA (ctDNA) presence and tumor features including tumor-infiltrating lymphocyte (TIL) levels in Peruvian breast cancer patients. Materials and Methods: This was a prospective study conducted at the Instituto Nacional de Enfemedades Neoplasicas, Peru. We evaluated level of TIL and PIK3CA mutations in ctDNA. Clinical characteristics, including outcome data, were collected from the patient file. Survival was calculated from the date of blood sample drawn to the event time. Data collected were analyzed using SPSS software version 25. Results: We analyzed plasma samples from 183 breast cancer patients. most cases were of Luminal-B (44.8%) phenotype and stage II (41.5%), and median stromal TIL was 30%. PIK3CA mutation in ctDNA was detected in 35% cases (most with E545K) and was associated with lower TIL level (p=0.04). PIK3CA in...