Objetivo: analizar la razón de muerte materna (RMM), sus características sociodemográficas y obstétricas de las muertes maternas (MM) ocurridas entre  años 2012 y 2018 en el Hospital Regional Docente de Cajamarca (HRDC). Métodos: Estudio descriptivo sobre datos obtenidos del registro de muertes maternas de la Oficina de Epidemiología de la DIRESA Cajamarca. Resultados : 42 MM, RMM promedio  171.4/100000 NV; 42.8% de  20 a 29 años de edad, 30.9% de 36 años a más. Procedieron de provincia de Cajamarca: 50%. Tuvieron estudios de primaria: 47.6%; analfabetas: 4.8%. Amas de casa: 80.9%; convivientes: 71.4%. Edad gestacional: 47.1% entre 28-36 semanas, 26.2% entre 37-40 semanas. 42.8% fueron multíparas, 4.8% gran multípara. Control prenatal: 69% inadecuado; afiliadas al SIS: 95%. MM directas: 76.2% y 23.8% indirectas; hipertensión inducida por embarazo: 65.6%; 21.9%...

Se hizo un estudio comparativo, prospectivo, transversal, aplicativo con diseño de una casilla con el objetivo de comparar la exactitud entre el Papanicolaou y la inspección visual con ácido acético (IVAA) en el tamizaje de las lesiones precursoras de cáncer de cuello uterino. Se evaluaron 138 pacientes del Preventorio Oncológico del Hospital Regional Docente de Cajamarca entre los 25 y 45 años, a quienes se les aplicaron ambos métodos de tamizaje y colposcopia con biopsia cervical – cuando estaba indicada- como método de referencia. Se halló que la exactitud de ambos métodos era similar (0.90 y 0.89 para el Papanicolaou y la inspección visual con ácido acético respectivamente), siendo el primer método más sensible, sin embargo, el segundo más específico. Se recomienda la implementación de la inspección visual con ácido acético en los lugares en que no esté dispo...

Objective: To determine the prevalence and risk factors of sexually transmitted infections (STIs) including Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma genitalium among asymptomatic women with human papillomavirus (HPV) infection. Methods: A cross-sectional study was performed in 842 asymptomatic women from Cajamarca, Peru. The pathogens were detected using polymerase chain reaction (PCR) and the results were analyzed according to the HPV status: high-risk HPV, low-risk HPV and negative for HPV. Demographical and gyneco-obstetric data was analyzed to identify risk factors. Results: We found that 23.99% (202/842) women were positive for HPV, of whom 79.21% (160/202) were infected with a high-risk genotype. Co-infections were evaluated and 14.38% (23/160) were positive for Ureaplasma urealyticum, 9.38% (15/160) for Chlamydia trachomatis and 1.25% (2/160) for Mycoplasma gen...

Objective: Describe the prevalence of HPV genotypes via PCR and DNA sequencing in 397 women who attended to the gynecological outpatient center in the Hospital Regional Docente de Cajamarca from March to September 2017. Results: A positive PCR result for HPV was observed in 121 cervical samples. A high-risk genotype was found in 63.6% (77/121) of patients, a probably oncogenic type in 23.1% (28/121) and a low-risk type in 7.4%. Among the high-risk genotypes, HPV-31 was the most common one present in 20% (21/77), followed by HPV-16 in 11.4% (12/77). Coinfections between two or more genotypes were observed in 12 cases.

Objective: To characterize the cervicovaginal microbiota of HPV-positive and HPV-negative asymptomatic Peruvian women, by identifying the presence of 13 representative bacteria genus. Results: A total of 100 HPV-positive and 100 HPV-negative women were matched by age for comparison of microbiota. The following bacteria were more frequently identified in HPV-positive patients compared to HPV-negative: Eubacterium (68 vs 32%), Actinobacteria (46 vs 33%), Fusobacterium (11 vs 6%) and Bacteroides (20 vs 13%). A comparison between high-risk and low-risk genotypes was performed and differences were found in the detection of Actinobacteria (50 vs 33.33%), Bifidobacterium (50 vs 20.83%) and Enterococcus (50 vs 29.17%).

Objective: To determine the general and genotype-specific prevalence of HPV and to identify potential risk factors for the infection in a population-based screening of Peruvian women. Results: A total of 524 samples were analyzed by PCR and a total of 100 HPV positive samples were found, of which 89 were high-risk, 19 were probably oncogenic, 9 were low-risk and 27 other HPV types. The 26–35 and 36–45 age groups showed the highest proportion of HPV positive samples with a total of 37% (37/100) and 30% (30/100), respectively. Moreover, high-risk HPV was found in 33.7% of both groups and probably oncogenic HPV in 52.6% and 31.6%, respectively. High-risk HPV were the most frequent types identified in the population studied, being HPV-52, HPV-31 and HPV-16 the most commonly detected with 17.6%, 15.7% y 12.9%, respectively. Demographic characteristics and habits were assessed in the studi...