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artículo

Perspectives on Strengthening Cancer Research and Control in Latin America Through Partnerships and Diplomacy: Experience of the National Cancer Institute's Center for Global...

Publicado por
Frech, S, Muha, CA, Stevens, LM, Trimble, EL, Brew, R, Perin, DP, Luciani, S, Mohar, A, Piñeros, M, Vidaurre, T, Morgan, DR, Hawk, ET, Schmeler, KM, Foxhall, LE, Rabadan-Diehl, C, Duran, D, Rendler-Garcia, M, Cazap, EL, Santini, L, Zoss, W, Delgado, LB, Pearlman, PC, Given, L, Hohman, K, Lopez, MS, Kostelecky, B

Publicado 2018

Enlace

According to the Pan American Health Organization, noncommunicable diseases, including cancer, are the leading causes of preventable and premature death in the Americas. Governments and health care systems in Latin America face numerous challenges as a result of increasing morbidity and mortality from cancer. Multiple international organizations have recognized the need for collaborative action on and technical support for cancer research and control in Latin America. The Center for Global Health at the US National Cancer Institute (NCI-CGH) is one entity among many that are working in the region and has sought to develop a strategy for working in Latin America that draws on and expands the collaborative potential of engaged, skilled, and diverse partners. NCI-CGH has worked toward developing and implementing initiatives in collaboration with global partners that share the common objecti...

artículo

Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project

Publicado por
Vale, FF, Roberts, RJ, Kobayashi, I, Camargo, MC, Rabkin, CS, Wang, D, Hicks, B, Zhu, B, Yeager, M, Hutchinson, A, Teshome, K, Jones, K, Luo, W, Goldstein, AM, Hu, N, Taylor, PR, Song, M, Gutiérrez-Escobar, AJ, Yu, K, Abnet, CC, Chanock, SJ, Romero-Gallo, J, Krishna, U, Peek, RM, Piazuelo, MB, Wilson, KT, Loh, JT, Cover, TL, Raaf, N, Aftab, H, Akada, J, Matsumoto, T, Yamaoka, Y, Haesebrouck, F, Bartelli, TF, Nunes, DN, Pelosof, A, Sztokfisz, CZ, Dias-Neto, E, Assumpção, PP, Tishkov, I, Goodman, KJ, Geary, J, Cromarty, TJ, Price, NL, Quilty, D, Corvalan, AH, Serrano, CA, Gonzalez, R, Riquelme, A, García-Cancino, A, Parra-Sepúlveda, C, Castillo, F, Bravo, MM, Pazos, A, Bravo, LE, Fox, JG, Ramírez-Mayorga, V, Molina-Castro, S, Durán-Bermúdez, S, Campos-Núñez, C, Chaves-Cervantes, M, Tshibangu-Kabamba, E, Tumba, GD, Tshimpi-Wola, A, de Jesus Ngoma-Kisoko, P, Ngoyi, DM, Cruz, M, Hosking, C, Abreu, JJ, Varon, C, Benejat, L, Jehanne, Q, Lehours, P, Megraud, F, Secka, O, Link, A, Malfertheiner, P, Adinortey, MB, Bockarie, AS, Adinortey, CA, Ofori, EG, Sgouras, DN, Martinez-Gonzalez, B, Michopoulos, S, Georgopoulos, S, Hernandez, E, Dominguez, RL, Morgan, DR, Harðardóttir, H, Gunnarsdóttir, AI, Guðjónsson, H, Jónasson, JG, Björnsson, ES, Ballal, M, Shetty, V, Miftahussurur, M, Sugihartono, T, Alfaray, RI, Waskito, LA, Fauzia, KA

Publicado 2024

Enlace

Prophages can have major clinical implications through their ability to change pathogenic bacterial traits. There is limited understanding of the prophage role in ecological, evolutionary, adaptive processes and pathogenicity of Helicobacter pylori, a widespread bacterium causally associated with gastric cancer. Inferring the exact prophage genomic location and completeness requires complete genomes. The international Helicobacter pylori Genome Project (HpGP) dataset comprises 1011 H. pylori complete clinical genomes enriched with epigenetic data. We thoroughly evaluated the H. pylori prophage genomic content in the HpGP dataset. We investigated population evolutionary dynamics through phylogenetic and pangenome analyses. Additionally, we identified genome rearrangements and assessed the impact of prophage presence on bacterial gene disruption and methylome. We found that 29.5% (298) of ...