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artículo

Clinical characteristics and outcomes of children with WAGR syndrome and Wilms tumor and/or nephroblastomatosis: The 30-year SIOP-RTSG experience

Publicado por
Hol, JA, Jongmans, MCJ, Sudour-Bonnange, H, Ramírez-Villar, GL, Chowdhury, T, Rechnitzer, C, Pal, N, Schleiermacher, G, Karow, A, Kuiper, RP, de Camargo, B, Avcin, S, Redzic, D, Wachtel, A, Segers, H, Vujanic, GM, van Tinteren, H, Bergeron, C, Pritchard-Jones, K, Graf, N, van den Heuvel-Eibrink, MM, International Society of Pediatric Oncology Renal Tumor Study Group (SIOP-RTSG)

Publicado 2021

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Background: WAGR syndrome (Wilms tumor, aniridia, genitourinary anomalies, and range of developmental delays) is a rare contiguous gene deletion syndrome with a 45% to 60% risk of developing Wilms tumor (WT). Currently, surveillance and treatment recommendations are based on limited evidence. Methods: Clinical characteristics, treatments, and outcomes were analyzed for patients with WAGR and WT/nephroblastomatosis who were identified through International Society of Pediatric Oncology Renal Tumor Study Group (SIOP-RTSG) registries and the SIOP-RTSG network (1989-2019). Events were defined as relapse, metachronous tumors, or death. Results: Forty-three patients were identified. The median age at WT/nephroblastomatosis diagnosis was 22 months (range, 6-44 months). The overall stage was available for 40 patients, including 15 (37.5%) with bilateral disease and none with metastatic disease. ...

artículo

Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project

Publicado por
Vale, FF, Roberts, RJ, Kobayashi, I, Camargo, MC, Rabkin, CS, Wang, D, Hicks, B, Zhu, B, Yeager, M, Hutchinson, A, Teshome, K, Jones, K, Luo, W, Goldstein, AM, Hu, N, Taylor, PR, Song, M, Gutiérrez-Escobar, AJ, Yu, K, Abnet, CC, Chanock, SJ, Romero-Gallo, J, Krishna, U, Peek, RM, Piazuelo, MB, Wilson, KT, Loh, JT, Cover, TL, Raaf, N, Aftab, H, Akada, J, Matsumoto, T, Yamaoka, Y, Haesebrouck, F, Bartelli, TF, Nunes, DN, Pelosof, A, Sztokfisz, CZ, Dias-Neto, E, Assumpção, PP, Tishkov, I, Goodman, KJ, Geary, J, Cromarty, TJ, Price, NL, Quilty, D, Corvalan, AH, Serrano, CA, Gonzalez, R, Riquelme, A, García-Cancino, A, Parra-Sepúlveda, C, Castillo, F, Bravo, MM, Pazos, A, Bravo, LE, Fox, JG, Ramírez-Mayorga, V, Molina-Castro, S, Durán-Bermúdez, S, Campos-Núñez, C, Chaves-Cervantes, M, Tshibangu-Kabamba, E, Tumba, GD, Tshimpi-Wola, A, de Jesus Ngoma-Kisoko, P, Ngoyi, DM, Cruz, M, Hosking, C, Abreu, JJ, Varon, C, Benejat, L, Jehanne, Q, Lehours, P, Megraud, F, Secka, O, Link, A, Malfertheiner, P, Adinortey, MB, Bockarie, AS, Adinortey, CA, Ofori, EG, Sgouras, DN, Martinez-Gonzalez, B, Michopoulos, S, Georgopoulos, S, Hernandez, E, Dominguez, RL, Morgan, DR, Harðardóttir, H, Gunnarsdóttir, AI, Guðjónsson, H, Jónasson, JG, Björnsson, ES, Ballal, M, Shetty, V, Miftahussurur, M, Sugihartono, T, Alfaray, RI, Waskito, LA, Fauzia, KA

Publicado 2024

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Prophages can have major clinical implications through their ability to change pathogenic bacterial traits. There is limited understanding of the prophage role in ecological, evolutionary, adaptive processes and pathogenicity of Helicobacter pylori, a widespread bacterium causally associated with gastric cancer. Inferring the exact prophage genomic location and completeness requires complete genomes. The international Helicobacter pylori Genome Project (HpGP) dataset comprises 1011 H. pylori complete clinical genomes enriched with epigenetic data. We thoroughly evaluated the H. pylori prophage genomic content in the HpGP dataset. We investigated population evolutionary dynamics through phylogenetic and pangenome analyses. Additionally, we identified genome rearrangements and assessed the impact of prophage presence on bacterial gene disruption and methylome. We found that 29.5% (298) of ...