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artículo

Treatment Efficacy, Adherence, and Quality of Life Among Women Younger Than 35 Years in the International Breast Cancer Study Group TEXT and SOFT Adjuvant Endocrine Therapy Trials

Publicado por
Saha, P, Regan, MM, Pagani, O, Francis, PA, Walley, BA, Ribi, K, Bernhard, J, Luo, W, Gómez, HL, Burstein, HJ, Parmar, V, Torres, R, Stewart, J, Bellet, M, Perelló, A, Dane, F, Moreira, A, Vorobiof, D, Nottage, M, Price, KN, Coates, AS, Goldhirsch, A, Gelber, RD, Colleoni, M, Fleming, GF, SOFT TEXT Investigators, International Breast Cancer Study Group

Publicado 2017

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Purpose To describe benefits and toxicities of adjuvant endocrine therapies in women younger than 35 years with breast cancer (n = 582) enrolled in the Suppression of Ovarian Function Trial (SOFT) and Tamoxifen and Exemestane Trial (TEXT). Methods In SOFT, women still premenopausal after surgery with or without chemotherapy were randomly assigned to tamoxifen alone, tamoxifen plus ovarian function suppression (OFS), or exemestane plus OFS. In TEXT, all received OFS with or without concomitant chemotherapy and were randomly assigned to exemestane plus OFS or tamoxifen plus OFS. We summarize treatment efficacy, quality of life, and adherence of the cohort of women younger than 35 years in SOFT and TEXT, alongside data from the cohort of older premenopausal women. Results For 240 human epidermal growth factor receptor 2-negative patients younger than 35 years enrolled in SOFT after receivin...

artículo

Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project

Publicado por
Vale, FF, Roberts, RJ, Kobayashi, I, Camargo, MC, Rabkin, CS, Wang, D, Hicks, B, Zhu, B, Yeager, M, Hutchinson, A, Teshome, K, Jones, K, Luo, W, Goldstein, AM, Hu, N, Taylor, PR, Song, M, Gutiérrez-Escobar, AJ, Yu, K, Abnet, CC, Chanock, SJ, Romero-Gallo, J, Krishna, U, Peek, RM, Piazuelo, MB, Wilson, KT, Loh, JT, Cover, TL, Raaf, N, Aftab, H, Akada, J, Matsumoto, T, Yamaoka, Y, Haesebrouck, F, Bartelli, TF, Nunes, DN, Pelosof, A, Sztokfisz, CZ, Dias-Neto, E, Assumpção, PP, Tishkov, I, Goodman, KJ, Geary, J, Cromarty, TJ, Price, NL, Quilty, D, Corvalan, AH, Serrano, CA, Gonzalez, R, Riquelme, A, García-Cancino, A, Parra-Sepúlveda, C, Castillo, F, Bravo, MM, Pazos, A, Bravo, LE, Fox, JG, Ramírez-Mayorga, V, Molina-Castro, S, Durán-Bermúdez, S, Campos-Núñez, C, Chaves-Cervantes, M, Tshibangu-Kabamba, E, Tumba, GD, Tshimpi-Wola, A, de Jesus Ngoma-Kisoko, P, Ngoyi, DM, Cruz, M, Hosking, C, Abreu, JJ, Varon, C, Benejat, L, Jehanne, Q, Lehours, P, Megraud, F, Secka, O, Link, A, Malfertheiner, P, Adinortey, MB, Bockarie, AS, Adinortey, CA, Ofori, EG, Sgouras, DN, Martinez-Gonzalez, B, Michopoulos, S, Georgopoulos, S, Hernandez, E, Dominguez, RL, Morgan, DR, Harðardóttir, H, Gunnarsdóttir, AI, Guðjónsson, H, Jónasson, JG, Björnsson, ES, Ballal, M, Shetty, V, Miftahussurur, M, Sugihartono, T, Alfaray, RI, Waskito, LA, Fauzia, KA

Publicado 2024

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Prophages can have major clinical implications through their ability to change pathogenic bacterial traits. There is limited understanding of the prophage role in ecological, evolutionary, adaptive processes and pathogenicity of Helicobacter pylori, a widespread bacterium causally associated with gastric cancer. Inferring the exact prophage genomic location and completeness requires complete genomes. The international Helicobacter pylori Genome Project (HpGP) dataset comprises 1011 H. pylori complete clinical genomes enriched with epigenetic data. We thoroughly evaluated the H. pylori prophage genomic content in the HpGP dataset. We investigated population evolutionary dynamics through phylogenetic and pangenome analyses. Additionally, we identified genome rearrangements and assessed the impact of prophage presence on bacterial gene disruption and methylome. We found that 29.5% (298) of ...