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Complex structural X chromosome abnormalities are rare in humans and animals, and not recurrent. Yet, each case provides a fascinating opportunity to evaluate X chromosome content and functional status in relation to the effect on the phenotype. Here, we report the first equine case of a complex unbalanced X-autosome rearrangement in a healthy but short in stature Thoroughbred mare. Studies of about 200 cells by chromosome banding and FISH revealed an abnormal 2n=63,X,der(X;16) karyotype with a large dicentric derivative chromosome (der). The der was comprised of normal Xp material, a palindromic duplication of Xq12q21, and a translocation of chromosome 16 to the inverted Xq12q21 segment by the centromere, whereas the distal Xq22q29 was deleted from the der. Microsatellite genotyping determined a paternal origin of the der. While there was no option to experimentally investigate the stat...

Esta tesis doctoral se realizó con el objetivo de proponer la implementación del eje de investigación formativa en el plan curricular de la FIM con la finalidad de formar profesionales investigadores.

La industria textil emplea ¨tintes artificiales¨ en las fibras de algodón, los cuales han resultado perjudiciales para la salud. El empleo de estos tintes puede ser reemplazado por el uso de variedades que producen fibras de colores, los algodones nativos del Perú, que poseen diferentes colores y tonalidades. Ante la necesidad de conocimiento en esta área se planteó como objetivo determinar la caracterización de los frutos, semillas y fibras de Gossypium barbadense “algodón pardo”. Las semillas procedieron de San Benito-Cajamarca, la fase experimental se realizó en el Laboratorio de Biotecnología del Instituto de la Papa y Cultivos Andinos de la Universidad Nacional de Trujillo con 30 repeticiones. En el fruto se encontró una longitud de 4,26 cm y un ancho de 4,11 cm. Además de presentar 3,5 lóculos por fruto. En la semilla, se presenció 0,78 cm de largo y 0,49 cm de an...

La industria textil emplea ¨tintes artificiales¨ en las fibras de algodón, los cuales han resultado perjudiciales para la salud. El empleo de estos tintes puede ser reemplazado por el uso de variedades que producen fibras de colores, los algodones nativos del Perú, que poseen diferentes colores y tonalidades. Ante la necesidad de conocimiento en esta área se planteó como objetivo determinar la caracterización de los frutos, semillas y fibras de Gossypium barbadense “algodón pardo”. Las semillas procedieron de San Benito-Cajamarca, la fase experimental se realizó en el Laboratorio de Biotecnología del Instituto de la Papa y Cultivos Andinos de la Universidad Nacional de Trujillo con 30 repeticiones. En el fruto se encontró una longitud de 4,26 cm y un ancho de 4,11 cm. Además de presentar 3,5 lóculos por fruto. En la semilla, se presenció 0,78 cm de largo y 0,49 cm de an...

Background From the social-ecological perspective, exposure to violence at the different developmental levels is fundamental to explain the dynamics of violence and victimization in educational centers. The following study aims at analyzing how these relationships are produced in the Peruvian context, where structural violence situations exist. Methods A multi-mediation structural model with 21,416 Peruvian adolescents (M = 13.69; SD = 0.71) was conducted to determine the influence of violence in the school environment on violence perceived within school and violence exercised by teachers. In addition, it was also intended to determine whether these violent relationships predict depression through loneliness, and bullying through peer victimization. The existence of differences between early and late adolescence was also verified. Results Results confirm that violence in the school setti...

The characterization of the thermal insulation properties of construction materials represents a fundamental step on building insulation assessment. The present work aims to design and build a portable apparatus, namely, Portable LAMBDA UNI, capable of measuring the thermal conductivity of insulation materials. This portable apparatus is based on the standard ASTM C 518, which is a secondary method for measuring thermal conductivity. The apparatus also measures the effective thermal conductivity of square prism thermal insulation materials of 60 mm per side and a maximum thickness of 14 mm. The thermal conductivity of the drywall and adobe with Stipa ichu was measured with the Portable LAMBDA UNI, with the values being 0.265 W m-1 K-1and 0.357 W m-1 K-1, respectively. © 2021 Published under licence by IOP Publishing Ltd.

Background: Pembrolizumab has efficacy in programmed death ligand 1 (PD-L1)-positive metastatic or unresectable cervical cancer that has progressed during chemotherapy. We assessed the relative benefit of adding pembrolizumab to chemotherapy with or without bevacizumab. Methods: In a double-blind, phase 3 trial, we randomly assigned patients with persistent, recurrent, or metastatic cervical cancer in a 1:1 ratio to receive pembrolizumab (200 mg) or placebo every 3 weeks for up to 35 cycles plus platinum-based chemotherapy and, per investigator discretion, bevacizumab. The dual primary end points were progression-free survival and overall survival, each tested sequentially in patients with a PD-L1 combined positive score of 1 or more, in the intention-to-treat population, and in patients with a PD-L1 combined positive score of 10 or more. The combined positive score is defined as the num...