Revisión Sistemática, observacional, retrospectiva. Población de 10 artículos en base de datos, texto completo, no mayor a 10 años, se usó sistema grade para determinar fuerza y calidad de evidencia; 40% de artículos proceden de EEUU, 10% de Australia y Reino Unido, 20% de Brasil y Perú. El 100% de artículos coincide que la estrategia del Coaching, contribuye al fortalecimiento del liderazgo en enfermeras gestoras, predominando el liderazgo transformacional. El fortalecimiento del liderazgo favorece el respeto y relaciones interpersonales satisfactorias con colaboradores; autoconocimiento, cambios actitudinales positivos, seguridad, confianza, resiliencia y madurez emocional, contribuyendo al mayor compromiso, capacidad de gestión, comunicación, toma de decisiones, resolución de conflictos, mejorando el desempeño laboral y logro de objetivos institucionales.

Estudio retrospectivo en 47 pacientes con Linfoma T del Hospital Nacional Edgardo Rebagliati Martins, de EsSalud durante el período 1997- 2004, para determinar la especificidad y el valor pronóstico de la expresión de Foxp3 en el linfoma de células T. La expresión de Foxp3 en células tumorales fue detectado en 8/33 (24%) casos de la Leucemia /Linfoma T del Adulto (ATLL) y en 2/8 (28%) linfomas T periféricos no especificados (LTPNE). No hubo diferencia estadística en sobrevida global entre el ATLL Foxp3 (+) y el ATLL Foxp3 (-). El Foxp3 está expresado en diferentes Linfomas T y no es un marcador específico para la identificación de ATLL. El estudio concluye que la expresión de Foxp3 puede darse en ATLL como en LTPNE.

Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance.Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma.Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004.Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATL...

Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance.Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma.Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004.Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATL...

El Linfoma de Células Grandes B difuso del anciano asociado al virus de Epstein Barr es una proliferación linfoide clonal de células B que ocurre en pacientes con más de 50 años y sin ninguna inmuno-deficiencia o linfoma previo. Está incluida en la clasificación de neoplasias linfoides de la WHO 2008. Usualmente afecta ancianos y tiene pobre sobrevida. El objetivo de este reporte fue evaluar las característica clínicas, endoscópicas y sobrevida de cinco pacientes portadores de esta entidad y compromiso gastrointestinal. Tres casos tuvieron infiltración gástrica y dos casos tuvieron compromiso del ileón y el ciego.

El Linfoma de Células Grandes B difuso del anciano asociado al Epstein Barr es una nueva entidad incluida provisionalmente en la más reciente clasificación de neoplasias linfoides de la WHO. Usualmente afecta ancianos y tiene pobre sobrevida. El objetivo de este reporte fue evaluar las característica clínicas, endoscópicas y sobrevida de cinco pacientes portadores de esta entidad y compromiso gastrointestinal. Tres casos tuvieron infiltración gástrica y dos casos tuvieron compromiso del ileón y el ciego.

Introduction: Age-related B-cell lymphoproliferative disorder associated with Epstein-Barr virus (EBV) is a newly described condition in our country. EBV infection may lead to a non-controlled growth of normally inactive B-lymphocytes, so lymphoproliferative disorders with an aggressive course and poor survival occur.Clinical cases: Nine Peruvian patients diagnosed with age-related B-cell lymphoproliferative disorder associated EBV were included in this report. All patients were positive for EBER test using chromogenic in situ hybridization (CISH). Morphology in every case corresponded to large-cell lymphoma. CD20, BCL6, CD10, and MUM-1/IRF4 histochemical expression was assessed using a tissue microarray. All nive patients had a phenotype not germinal center-like. Most of our patients were elderly subjects with a poor performance status, type B symptoms, high values in the Inte...

Introduction: Age-related B-cell lymphoproliferative disorder associated with Epstein-Barr virus (EBV) is a newly described condition in our country. EBV infection may lead to a non-controlled growth of normally inactive B-lymphocytes, so lymphoproliferative disorders with an aggressive course and poor survival occur.Clinical cases: Nine Peruvian patients diagnosed with age-related B-cell lymphoproliferative disorder associated EBV were included in this report. All patients were positive for EBER test using chromogenic in situ hybridization (CISH). Morphology in every case corresponded to large-cell lymphoma. CD20, BCL6, CD10, and MUM-1/IRF4 histochemical expression was assessed using a tissue microarray. All nive patients had a phenotype not germinal center-like. Most of our patients were elderly subjects with a poor performance status, type B symptoms, high values in the Inte...

Introducción: El virus del papiloma humano (VPH) es un agente involucrado en la patogénesis del cáncer de cérvix. Varios reportes describen una asociación entre VPH y carcinoma escamoso de esófago (CEE). Objetivo: determinar la frecuencia de infección del PVH de alto riesgo y el CEE. Material y método: se realizó un estudio retrospectivo del universo de caso, n= 29 de CEE diagnosticados del 2003 al 2006 con estudio anatomopatológico en el Hospital Edgardo Rebagliati Martins, Lima, Perú. La muestras parafinadas fueron sometidas a PCR-RT para la detección de PVH 16,18,31,33 y 45 . Resultados: la edad media fue de 73 años, la relación masculino/ femenino fue 3. Los estadios fueron : estadio I :1 caso; estadio II: 12 casos, estadio III:14 casos y estadio IV: 2 casos. No se detectó en ningún caso VPH de alto riesgo a pesar de emplear dos sondas diferentes. Conclusión: el VPH ...

Introduction: Human papilloma virus (HPV) is an agent involved in the pathophysiology of cervical cancer. Many reports describe an association between HPV and esophageal squamous-cell carcinoma (ESCC).Objective: The main objective of the study is to determine the frequency of high-risk HPV infection and ESCC.Material and method: A retrospective study including 29 ESCC cases with a histological and pathological diagnosis from 2003 to 2006 in Edgardo Rebagliati-Martins Hospital in Lima, Peru. Paraffin-embedded tissue fragments underwent RT-PCR tests for detecting HPV types 16, 18, 31, 33, and 45.Results: Mean age of patients was 73 years, male to female ratio was 3. Stage I disease was found in one case; stage II disease in 12 cases, stage III disease in 14 cases, and stage IV in 2. No highrigh HPV was found in any of the samples studied, even though we used two differe...

Introduction: Human papilloma virus (HPV) is an agent involved in the pathophysiology of cervical cancer. Many reports describe an association between HPV and esophageal squamous-cell carcinoma (ESCC).Objective: The main objective of the study is to determine the frequency of high-risk HPV infection and ESCC.Material and method: A retrospective study including 29 ESCC cases with a histological and pathological diagnosis from 2003 to 2006 in Edgardo Rebagliati-Martins Hospital in Lima, Peru. Paraffin-embedded tissue fragments underwent RT-PCR tests for detecting HPV types 16, 18, 31, 33, and 45.Results: Mean age of patients was 73 years, male to female ratio was 3. Stage I disease was found in one case; stage II disease in 12 cases, stage III disease in 14 cases, and stage IV in 2. No highrigh HPV was found in any of the samples studied, even though we used two differe...

El presente reporte de casos muestra los resultados del empleo de bexaroteno en dosis bajas más fototerapia o Interferon alfa 9 millones en el tratamiento del linfoma cutáneo de células T (LCCT). Ocho pacientes fueron tratados, cinco fueron Micosis fungoides, dos Linfoma Epidermotrópico CD8 agresivo y uno fue un Síndrome Sézary. La respuesta global fue del 62.5% (5/8) y la duración media de respuesta fue de 20 meses. El bexaroteno en dosis bajas en combinación a fototerapia o Interferon alfa 2a puede ser efectivo en el tratamiento del LCCT.

Se realizó un estudio retrospectivo clínicopatológico de 78 casos de linfomas cutáneos, diagnosticados desde 1997 al 2004 en el Hospital Edgardo Rebagliati Martins, de EsSalud, en Lima, Perú. El objetivo de este estudio fue determinar la frecuencia relativa de los linfomas cutáneos y examinar la relevancia clínica de la nueva clasificación WHO/EORTC y la sobrevida de los casos peruanos de linfoma primario cutáneo. Fueron revisadas las historias clínicas, biopsias y pruebas de inmunohistoquímica de los 78 pacientes enrolados. El 85,9% fueron linfomas primarios cutáneos y 14,1% fueron linfomas cutáneos secundarios. La micosis fungoide (MF) y el linfoma /leucemia T del adulto (ATLL) fueron los linfomas primarios cutáneos más frecuentes en nuestro hospital. La MF posee un buen pronóstico mientras el ATLL cutáneo posee pobre sobrevida.

Introduction: Clinico-pathological features of malignant lymphomas vary according to geography. The skin is the second site for extranodal Non-Hodgkin Lymphoma. Primary cutaneous lymphoma has a different clinical behavior and prognosis compared with systemic lymphomas.Objective: The aim of this study was to determine the relative rate of cutaneous lymphomas and to examine the clinical relevance of the new WHO/EORTC classification and survival in Peruvian persons with primary cutaneous lymphoma.Methods: We conducted a clinico-pathological retrospective study in 78 cases of cutaneous lymphoma diagnosed between 1997 and 2004 in a National General Hospital. Clinical records, hematoxylin & eosin-stained slides and immunohistochemical studies from 78 patients with malignant lymphoma of the skin were reviewed.Results: 67/78 cases (85,9%) were primary cutaneous lymphomas and 11/78 ...

Introduction: Bexarotene is a rexinoid compound that is approved for use in the therapy for early and advanced stage cutaneous T-cell lymphoma (CTCL).Clinical Cases: We present in this report the results of the use of low-dose bexarotene plus phototherapy or alpha-interferon, nine million units, in the treatment of CTCL. Eight patients were treated, five had mycosis fungoides, two had CD-8 epidermothropic aggressive lymphoma. The overall response rate was 62.5% (5/8), and the mean duration of response was 20 months. Low-dose bexarotene combined with phototherapy or alpha-interferon may be effective in the treatment of CTCL.

Introduction: Clinico-pathological features of malignant lymphomas vary according to geography. The skin is the second site for extranodal Non-Hodgkin Lymphoma. Primary cutaneous lymphoma has a different clinical behavior and prognosis compared with systemic lymphomas.Objective: The aim of this study was to determine the relative rate of cutaneous lymphomas and to examine the clinical relevance of the new WHO/EORTC classification and survival in Peruvian persons with primary cutaneous lymphoma.Methods: We conducted a clinico-pathological retrospective study in 78 cases of cutaneous lymphoma diagnosed between 1997 and 2004 in a National General Hospital. Clinical records, hematoxylin & eosin-stained slides and immunohistochemical studies from 78 patients with malignant lymphoma of the skin were reviewed.Results: 67/78 cases (85,9%) were primary cutaneous lymphomas and 11/78 ...

Introduction: Bexarotene is a rexinoid compound that is approved for use in the therapy for early and advanced stage cutaneous T-cell lymphoma (CTCL).Clinical Cases: We present in this report the results of the use of low-dose bexarotene plus phototherapy or alpha-interferon, nine million units, in the treatment of CTCL. Eight patients were treated, five had mycosis fungoides, two had CD-8 epidermothropic aggressive lymphoma. The overall response rate was 62.5% (5/8), and the mean duration of response was 20 months. Low-dose bexarotene combined with phototherapy or alpha-interferon may be effective in the treatment of CTCL.