Age-related and Epstein Barr virus-associated B-cell lymphoproliferative disorder: a 9-case report and literature review

• Autores: Beltran Garate, Brady, Morales Luna, Domingo, Quiñones Ávila, Pilar, Hurtado de Mendoza Acurio, Fernando, Cotrina Montenegro, Esther, Riva Gonzáles, Luis
• Formato: artículo
• Fecha de Publicación: 2008
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/1348
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1348
• Nivel de acceso: acceso abierto
• Materia: Virus Epstein Barr; Herpesvirus 4 humano; Desorden linfoproliferativo; Sobrevida; Epstein Barr virus; Human herpes virus 4; Lymphoproliferative disorder; Survival

Introduction: Age-related B-cell lymphoproliferative disorder associated with Epstein-Barr virus (EBV) is a newly described condition in our country. EBV infection may lead to a non-controlled growth of normally inactive B-lymphocytes, so lymphoproliferative disorders with an aggressive course and poor survival occur.Clinical cases: Nine Peruvian patients diagnosed with age-related B-cell lymphoproliferative disorder associated EBV were included in this report. All patients were positive for EBER test using chromogenic in situ hybridization (CISH). Morphology in every case corresponded to large-cell lymphoma. CD20, BCL6, CD10, and MUM-1/IRF4 histochemical expression was assessed using a tissue microarray. All nive patients had a phenotype not germinal center-like. Most of our patients were elderly subjects with a poor performance status, type B symptoms, high values in the International Prognostic Index (IPI) and advanced disease. Their survival was quite short.Conclusion: We report for the first time a new condition called age-related B-cell lymphoproliferative disorder associated EBV, which has an aggressive course and a poor prognosis.