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1
artículo
Publicado 2017
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Spermidine is a polyamine compound found in fruits, vegetables, meats and milk products. It is also known for its role as a modulator of functions for DNA, RNA, nucleotide triphosphates and proteins. Some recent experimental studies have shown that it has an inhibitory function on the protein related to the pathogenesis of myotonic dystrophy type 1 (MBNL‐1), providing some hope in relation to this disease presently without cure. However these studies have not provided sufficient information to explain its inhibitory role. In the present work, the existing interaction between spermidine and the MBNL‐1 protein has been confirmed by computational chemistry. The quantum mechanics analysis was carried out with the CAM‐B3LYP density functional, using a TZVP basis set. For the molecular mechanics, the OPLS‐AA force field was used, followed immediately by the solvation of the MBNL‐1 pr...
2
artículo
Publicado 2017
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Spermidine is a polyamine compound found in fruits, vegetables, meats and milk products. It is also known for its role as a modulator of functions for DNA, RNA, nucleotide triphosphates and proteins. Some recent experimental studies have shown that it has an inhibitory function on the protein related to the pathogenesis of myotonic dystrophy type 1 (MBNL‐1), providing some hope in relation to this disease presently without cure. However these studies have not provided sufficient information to explain its inhibitory role. In the present work, the existing interaction between spermidine and the MBNL‐1 protein has been confirmed by computational chemistry. The quantum mechanics analysis was carried out with the CAM‐B3LYP density functional, using a TZVP basis set. For the molecular mechanics, the OPLS‐AA force field was used, followed immediately by the solvation of the MBNL‐1 pr...
3
artículo
Publicado 2022
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Gaussian processes that can be decomposed into a smooth mean function and a stationary autocorrelated noise process are considered and a fully automatic nonparametric method to simultaneous estimation of mean and auto-covariance functions of such processes is developed. The proposed empirical Bayes approach is data-driven, numerically efficient, and allows for the construction of confidence sets for the mean function. Performance is demonstrated in simulations and real data analysis. The method is implemented in the R package eBsc.
4
artículo
Publicado 2022
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The science courses are and will be the basis of the students' knowledge, in this sense the mathematics course is considered the most important course because in its content it presents topics related to calculus, making their learning of vital importance in the design of educational processes. Finance a review of the state of the art we find a series of works dedicated to being able to enhance the mechanisms used for teaching, from the use of scientific calculators to reaching certain computer programs of common use, in this work a methodology is developed to be able to enhance the programming skills that teachers have in a specific area of programming, where we can consider any programming language but also any computer tool such as Excel spreadsheets. The methodology proposes the organization of topics as specific theories, such as algebra, arithmetic, trigonometry, geometry, where sp...
5
artículo
The need to develop a BCI brain- computer interface system for the control of a robotic arm in Peru arises from the possibility of interconnecting the human nervous system with a robotic or mechatronic system, and using this concept to recover some motor function. Brain Computer Interface (BCI) is a communication system based on the recording of brain signals (EEG). The electroencephalogram is the basis and support of the BCI technology. It is a novel technology that allows human-machine interaction in a virtual or physical environment, through a communication channel between the central nervous system and a robotic device. In recent years, the aforementioned systems have caused the interest of important research centers worldwide.
6
artículo
Publicado 2025
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Purpose: The aim of this article is to establish a theoretical-methodological proposal to study discursive interactivity from a multidisciplinary perspective different from the traditional structural and quantitative media research. The sociological definition of interaction and the basis of discourse analysis –as a theoretical discipline and scientific method– are assumed to propose a concept of interactivity that addresses the double materiality of the term: as a structure and a process. Methodology: Grounded theory becomes a methodological strategy and is complemented by the bibliographic-documentary method and discourse analysis. By means of theoretical sampling, codification, constant comparison and theoretical saturation, a category is determined that emerges as central, for which the following are established: conceptual definition, dimensions, subcategories and indicators. Re...
7
artículo
Publicado 2021
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The influence of family and school on the level of independence of pre-school children is a fundamental aspect of integral development in early ages. This study has a quantitative descriptive approach. The aim of this study was to know the degree of Functional Independence in pre-school children in Cuenca (Ecuador). The participants were 30 children (3-5 years old), 15 from a public institution and 15 from a private one. The Pediatric Evaluation of Disability Inventory Computer Adaptive Test (PEDICAT) was used as an evaluation tool, which measures the level of independence in 4 areas. The results showed that the children from the private institution were more independent in the areas of Daily and Social Cognitive Activities; while in the area of Mobility and Responsibility both groups obtained the same level. These data served as a basis to develop a parent working guide, in which activi...
8
artículo
Publicado 2022
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The objective of this article is to identify the results of the functionality of the learning platform and its effect on the satisfaction of mechanical and electrical engineering students. The results will serve as a basis for the continuous improvement of teaching-learning online from the higher institution. The research findings indicate that the indicators that present a better perception regarding the functionality of the learning platform are related to the design and ease of navigation. However, 21.4% of the students are not entirely satisfied with its functionality due to the technical problems presented when downloading the study material. According to the results, we can point out that the functionality of the learning platform generates an effect of 70.87% on student satisfaction, the relationship was validated through the Chi-square test, in which it is determined that the ind...
9
tesis doctoral
Publicado 2020
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Descargue el texto completo en el repositorio institucional de la Universidade Estadual de Campinas: https://hdl.handle.net/20.500.12733/1641647
10
tesis de grado
Cálculo de la energía total del sistema Fierro - Vanadio en la estructura BCC por método AB - Initio
Publicado 2015
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En el presente trabajo de investigación se han analizado y obtenido la energía total y las propiedades electrónicas (el parámetro de red, el momento magnético, el módulo de compresibilidad, la densidad de estados y las bandas de energía) de las diferentes fases del sistema Fierro-Vanadio (Fe-V), en la estructura cúbica de cuerpo centrado (BCC), obtenidos con el método ab-initio o de primeros principios llamado Full-Potential Linearized Augmented Plane Wave (FP-LAPW) en la versión del código computacional WIEN2k-10; el cual es un método que está basado en la Teoría Funcional de la Densidad y que utiliza como aproximación para la base de los orbitales las ondas planas aumentadas linearizadas. Se obs~rvó qu<; 1¡:¡. presencia del Vanadio (V) disminuye el carácter magnético del Hierro (Fe) en la estructura FeV3 en un 99% comparado con el carácter magnético del Hierro (Fe...
11
tesis de maestría
Publicado 2017
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El presente proyecto de innovación está orientado a resolver el problema público del proceso de asignación de personal dentro de la Policía Nacional, el cual ha venido desarrollándose a través de los años, de forma manual, siguiendo los parámetros de las ex instituciones que la conforman y sin tener en cuenta para ello, las especialidades funcionales contenidas en la normatividad interna. Actualmente, la labor de la Policía Nacional se muestra eficaz, en el combate a la inseguridad ciudadana pero no eficiente debido a que no se emplea adecuada y racionalmente el capital humano, asignando al personal de manera discrecional, priorizando el mayor número en labores de patrullaje y de presencia en las calles, antes que en el trabajo especializado, debido por un lado a que la normativa se encuentra inadecuadamente delimitada y por otro a la existencia de una débil sistematización ...
12
artículo
Publicado 2019
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The present work is oriented to offer a communication via to the many people who undergo of a severe loss of function motorboat as a result of different accidents and/or diseases, so that they can control and interact better with his environment, for which an brain-computer interface has been implemented through the acquisition of EEG signals by electrodes, implementation of algorithms to extract characteristics and to execute a method of classification of such way to interpret these signals and to execute corresponding actions. The first objective to design and to construct to a System of Communication and Control Based on the Thought able to catch and to measures EEG signals. The second objective is to implement the system of data acquisition including a digital filter in real time that allows us to eliminate the noise. The third objective is to analyze the variation of the EEG signals...
13
tesis de grado
Publicado 2021
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The sampling task of Seq2Seq models in Natural Language Processing (NLP) is based on heuristics because of the Non-Deterministic Polynomial Time (NP) nature of this problem. The goal of this research is to develop a quantum sampler for Seq2Seq models, and give evidence that Quantum Annealing (QA) can guide the search space of these samplers. The contribution of this work is given by showing an architecture to represent Recurrent Neural Networks (RNN) in a quantum computer to finally develop a quantum sampler. The individual architectures (i.e. summation, multiplication, argmax, and activation functions) achieve optimal accuracies in both simulated and quantum environments. While the results of the overall proposal show that it can either outperform or match greedy approaches. As the very first steps of quantum NLP, these are tested against simple RNN with a synthetic data set of random n...
14
tesis de grado
Publicado 2021
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The sampling task of Seq2Seq models in Natural Language Processing (NLP) is based on heuristics because of the Non-Deterministic Polynomial Time (NP) nature of this problem. The goal of this research is to develop a quantum sampler for Seq2Seq models, and give evidence that Quantum Annealing (QA) can guide the search space of these samplers. The contribution of this work is given by showing an architecture to represent Recurrent Neural Networks (RNN) in a quantum computer to finally develop a quantum sampler. The individual architectures (i.e. summation, multiplication, argmax, and activation functions) achieve optimal accuracies in both simulated and quantum environments. While the results of the overall proposal show that it can either outperform or match greedy approaches. As the very first steps of quantum NLP, these are tested against simple RNN with a synthetic data set of random n...
15
tesis de grado
Publicado 2013
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La Facultad de Ingeniería de Sistemas e Informática (FISI), ubicada en la Ciudad de Iquitos, Departamento de Loreto, Provincia de Maynas, es parte componente de la UNAP, creada para la formación profesional humanista e integral, con calidad y excelencia en el campo de la Ingeniería de Sistemas e Informática, orientada hacia un liderazgo de equipos multidisciplinarios que sean capaces de dar soluciones adecuadas a problemas relacionados con el desarrollo sostenible de la Región Amazónica; que como objetivo principal tiene la labor de formar Profesionales con capacidad y excelencia, generadores de ciencia y tecnología, con valores éticos y visión empresarial, capaces de promover o propiciar el desarrollo sustentable de la Amazonía. Entre otras funciones importantes entre las que mencionaremos que son de interés para el desarrollo del presente Trabajo Práctico, es la de supervi...
16
tesis de maestría
Publicado 2017
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El presente proyecto de innovación está orientado a resolver el problema público del proceso de asignación de personal dentro de la Policía Nacional, el cual ha venido desarrollándose a través de los años, de forma manual, siguiendo los parámetros de las ex instituciones que la conforman y sin tener en cuenta para ello, las especialidades funcionales contenidas en la normatividad interna. Actualmente, la labor de la Policía Nacional se muestra eficaz, en el combate a la inseguridad ciudadana pero no eficiente debido a que no se emplea adecuada y racionalmente el capital humano, asignando al personal de manera discrecional, priorizando el mayor número en labores de patrullaje y de presencia en las calles, antes que en el trabajo especializado, debido por un lado a que la normativa se encuentra inadecuadamente delimitada y por otro a la existencia de una débil sistematización ...
17
tesis de grado
Publicado 2012
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SISTEMA INFORMÁTICO PARA LA MEJORA DEL CONTROL DE LA PRODUCCIÓN DE CALZADO EN LA EMPRESA CONSORCIO A&G Por Br. José Manuel Rosas Cabeza El propósito del sistema es servir como soporte a las tareas de control de las órdenes de producción en el área de fabricación y producción de calzado de la empresa Consorcio A&G. El sistema ha sido construido tomando como referencia la metodología RUP para el proceso de desarrollo de software que actualmente tiene un gran impacto y jerarquía en la industria del software; siendo esa, una de las principales razones para ser utilizada. Gracias a su flexibilidad, permitió adecuar las necesidades de la organización, facilitando la realización de flujos de trabajo óptimos considerados en cada fase del desarrollo del proyecto. Adicionalmente, el uso de UML como lenguaje de modelado facilitó, gracias a su notación gráfica, una mejor comprensi...
18
tesis de maestría
Publicado 2023
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Una Interfaz Cerebro - Computador es una tecnología que permite a las personas comunicarse, activar y controlar dispositivos electrónicos, usando señales cerebrales, las cuales son adquiridas y procesadas por un computador, ayudando principalmente a pacientes con enfermedades neurológicas, neuromusculares o neurodegenerativas, quienes, debido a la enfermedad, han perdido la capacidad de hablar, caminar o realizar movimientos musculares. En esta tesis se propone un método de extracción de características y clasificación de señales, aplicado a una base de datos que contiene señales cerebrales de 4 personas (2 sanas y 2 con enfermedades neurodegenerativas), la primera persona enferma padecía Esclerosis Múltiple y la segunda persona enferma padecía Esclerosis Lateral Amiotrófica. Estas señales contienen en ciertos tramos ondas P300 no observables a simple vista, que surgieron ...
19
tesis de grado
Publicado 2018
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This paper describes the elaboration and implementation of the preventive maintenance program for trailers of the company INDUAMERICA LOGISTICAL SERVICES S.A.C. The implementation of the preventive maintenance program in INDUAMERICA LOGISTICAL SERVICES S.A.C. aims to guarantee the operational readiness of the company´s trailers, in an efficient and safe way, in order to contribute towards achieving the objectives established by the company. Firstly, was conducted the diagnostics of the maintenance function within INDUAMERICA LOGISTICAL SERVICES S.A.C; describing the strengths and weakness is in the connection. During the implementation was carried out the total inventory of trailers belonging to the company, then the criticality index was determined for each of them. The preventive maintenance program was designed in basis on critical points, which consists of tasks in specific function...
20
tesis de grado
Publicado 2008
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Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía (LIPNAA) realiza investigaciones multidisciplinarias e interinstitucionales tendientes a la búsqueda, obtención y evaluación de nuevos agentes antimaláricos de origen natural, inmunología y genética de la malaria para la creación de un banco de cepas nativas de Plasmodium falciparum y otras investigaciones en parásitos de origen endémico. Está formado por cuatro laboratorios, los cuales realizan sus funciones descritas a través de proyectos elaborados para cumplir su fin específico. Actualmente, el LIPNAA se apoya en una base de datos diseñada en ® Microsoft Office Excel, donde tienen registrados muestras biológicas, datos de donantes y los seguimientos de las cepas de los cultivos de malaria; teniendo como principal problema la ausencia de una herramienta informática que permita facilit...
