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1
artículo
Objective. To describe the impacts of the preliminary works of what will be the megaport of Chancay (Peru), referred to the transformation of the coastal strip of the bay. Methods. The study had a qualitative approach and resorted to a combination of environmental history methodology and the use of photographs to visualize the changes that have occurred in the bay over time. Results. There was evidence of transformation in the configuration of the coastal area of the bay due to anthropic action, which can be summarized in the annulment of the bay's function that generated the alteration of the coastline, sedimentation processes and alteration of the coastal marine ecosystem. Conclusions. The bay of Chancay and its coastal strip have been transformed by the preliminary works of what will be a megaport. The transformation has meant the loss of the beach as a recreational space and habitat ...
2
artículo
Publicado 2018
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The complex refractive indices of formamidinium cesium lead mixed-halide [FA0.83Cs0.17Pb(I1– xBrx)3] perovskite thin films of compositions ranging from x = 0 to 0.4, with both flat and wrinkle-textured surface topographies, are reported. The films are characterized using a combination of variable angle spectroscopic ellipsometry and spectral transmittance in the wavelength range of 190 nm to 850 nm.
3
artículo
Alianzas Socio-Técnicas y Políticas de Medicamentos: perspectivas desde la crisis Argentina del 2001
Publicado 2024
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The aim of this article is to analyse the problem-solution dynamics linked to the availability of and access to medicines for the Argentine population as a result of the social, economic, political and health crisis that affected Argentina in 2001.It is interesting to analyse the scope, characteristics and limitations of the public policies implemented by the Argentinean government between 2002 and 2008, whose objectives were to solve the problem of the lack of access to medicines that affected the most vulnerable sectors of the Argentinean population.The analytical reconstruction of this socio-institutional dynamic will provide a better understanding of the process of co-construction of public policies, regulations, artefacts, economic interests, ideologies and inclusive techno-productive development dynamics, and will offer new explanations about the functioning/non-functioning of the ...
4
artículo
Publicado 2024
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The aim of this article is to analyse the problem-solution dynamics linked to the availability of and access to medicines for the Argentine population as a result of the social, economic, political and health crisis that affected Argentina in 2001.It is interesting to analyse the scope, characteristics and limitations of the public policies implemented by the Argentinean government between 2002 and 2008, whose objectives were to solve the problem of the lack of access to medicines that affected the most vulnerable sectors of the Argentinean population.The analytical reconstruction of this socio-institutional dynamic will provide a better understanding of the process of co-construction of public policies, regulations, artefacts, economic interests, ideologies and inclusive techno-productive development dynamics, and will offer new explanations about the functioning/non-functioning of the ...
5
artículo
Publicado 2023
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Sensing drug substances by nanostructures are very important in accordance with the management of targeted drug delivery processes and drug substances detections. Boron nitride (BN), aluminum nitride (AlN), and gallium nitride (GaN) decorated carbon cage (BN-C, AlN-C, and GaN-C) scaffolds were assessed towards sensing the thiamazole (TMZ) drug through the wB97XD/6–31 + G* level of density functional theory (DFT) computations. The singular models were optimized and their combinations to each other were stabilized to obtain the interacting TMZ@Scaffold bimolecular complexes and their corresponding features. The results indicated the existence of non-covalent physical interactions between the substances and their electronic features indicated possibility of sensing function for the investigated scaffolds. Based on the variations of values of adsorption energy and energy gap, the features ...
6
artículo
InnovatePeru [382-PNICP-PIBA-2014 and 297INNOVATEPERU-EC-2016 to P.M.]; Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica [154-2017-Fondecyt and 0362019-Fondecyt-BM-INC.INV to P.M.]; FIRB Futuro in Ricerca [RBFR130VS5 001 to A.F.]; Italian Ministero dell'Istruzione, dell'Universita e della Ricerca (to A.F.); Part of the work on structural dynamics of the ribosome was supported by Russian Science Foundation [17-1401416 to A.L.K.]. Funding for open access: Universidad Peruana de Ciencias Aplicadas (Exp-03).
7
artículo
Publicado 1998
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El sitio de Chavín de Huántar ha sido excavado durante mucho tiempo, pero debido a la falta de planos precisos, no se ha realizado un análisis sofisticado de la arquitectura de superficie. Este artículo revisa aun los mapas anteriormente publicados antes de presentar los resultados preliminares del proyecto de mapeo y representación tridimensional de la arquitectura externa y la de las galerías. Se combina un análisis del modelo con los resultados de excavaciones estratégicas realizadas para revelar las uniones de segmentos arquitectónicos para aclarar el crecimiento del centro monumental. Aunque las conclusiones apoyan la idea de un Templo Viejo que es anterior a un Templo Nuevo, las relaciones entre edificios específicos son mucho más complejas que lo sugerido por reconstrucciones anteriores. Se registró una estructura más antigua que el Templo Viejo, y se revisan las fech...
8
tesis de grado
Publicado 2017
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En el presente trabajo, se modificó químicamente al alginato de sodio con tiosemicarbazida (TSC), mediante una reacción oxidativa con peryodato de sodio en medio acuoso a temperatura ambiente bajo completa oscuridad. El producto sintetizado es un alginato parcialmente oxidado, el cual se hizo reaccionar con la TSC en medio acuoso entre 40 - 45 °C para finalmente obtener el alginato modificado (Alg-TSC). La tiosemicarbazida presenta en su estructura un grupo tiona (C=S) y un grupo amino libre (-NH2) lo que le permite actuar conjuntamente con el grupo carboxilato (COO-) propio del alginato, como un agente quelante cuya función principal es la de coordinarse a centros metálicos pesados, tales como el cadmio (Cd) y el plomo (Pb). Se obtuvieron los espectros IR en modo reflactancia total atenuada, tanto del alginato de sodio sin modificar, del alginato oxidado, del alginato modificado c...
9
tesis de grado
Publicado 2024
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La salinización del suelo es un creciente problema ambiental que reduce el crecimiento y la capacidad fotosintética de las especies vegetales, siendo un factor determinante en la composición, distribución geográfica y diversidad de las comunidades de plantas, principalmente en ecosistemas áridos y semiáridos. Ante la salinización del suelo, las plantas reducen el impacto negativo del estrés salino sobre su desempeño biológico a través de cambios morfológicos, fisiológicos y bioquímicos. En zonas áridas como el bosque seco norperuano, la sequía y altas temperaturas pueden favorecer la acumulación de sales en el suelo, lo que podría alterar la distribución y abundancia de las especies habitantes según su tolerancia. En este ecosistema co-ocurren los arbustos predominantes Beautempsia aviceniifolia y Capparicordis crotonoides (Capparaceae), que bajo el supuesto de que e...
10
tesis de maestría
The field of autonomous driving has been evolving rapidly within the last few years and a lot of research has been dedicated towards the control of autonomous vehicles, especially car-like ones. Due to the recent successes of artificial intelligence techniques, even more complex problems can be solved, such as the control of autonomous multibody vehicles. Multibody vehicles can accomplish transportation tasks in a faster and cheaper way compared to multiple individual mobile vehicles or robots. But even for a human, driving a truck-trailer is a challenging task. This is because of the complex structure of the vehicle and the maneuvers that it has to perform, such as reverse parking to a loading dock. In addition, the detailed technical solution for an autonomous truck is challenging and even though many single-domain solutions are available, e.g. for pathplanning, no holistic framework e...
11
tesis de grado
Publicado 2017
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Los anestésicos locales en estomatología vienen siendo utilizados desde principios del siglo XX en las diversas disciplinas de la odontología, demostrando gran efectividad. Los anestésicos locales se definen como la pérdida de sensibilidad temporal sin ocasionar pérdida de conciencia lo que la diferencia de la anestesia general. Entender los mecanismos del funcionamiento de la conducción nerviosa es de suma importancia para la comprensión del modo en el que estos fármacos actúan y modifican de manera reversible la función nerviosa; nace de este modo diversas teorías y/o postulados para explicar la manera de funcionamiento de los anestésicos locales y una de las teorías con más seguidores es la de los receptores específicos. Los anestésicos locales poseen una estructura química compleja que le confiere a estos ciertas características como el lugar donde se va llevar a c...
12
artículo
Publicado 2018
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The complex refractive indices of formamidinium cesium lead mixed-halide [FA0.83Cs0.17Pb(I1– xBrx)3] perovskite thin films of compositions ranging from x = 0 to 0.4, with both flat and wrinkle-textured surface topographies, are reported. The films are characterized using a combination of variable angle spectroscopic ellipsometry and spectral transmittance in the wavelength range of 190 nm to 850 nm. Optical constants, film thicknesses and roughness layers are obtained point-by-point by minimizing a global error function, without using optical dispersion models, and including topographical information supplied by a laser confocal microscope.
13
tesis de maestría
Publicado 2018
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The complex refractive indices of formamidinium cesium lead mixed-halide (FA0.83Cs0.17Pb(I1 − xBrx)3) perovskite thin films of compositions ranging from x = 0 to 0.4, with both flat and wrinkle-textured surface topographies, are reported. Films are characterized using a combination of variable angle spectroscopic ellipsometry and spectral transmittance in the wavelength range of 190 nm to 850 nm. Optical constants, film thicknesses and roughness layers are obtained point-by-point by minimizing a global error function, without using optical dispersion models, and including topographical information supplied by a laser confocal microscope. To evaluate the bandgap engineering potential of the material, the optical bandgaps and Urbach energies are then accurately determined by applying a band fluctuations model for direct semiconductors, which considers both the Urbach tail and the fundame...
14
tesis doctoral
Publicado 2023
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State-of-the-art control and robotics challenges have long been tackled using model-based control methods like model predictive control (MPC) and reinforcement learning (RL). These methods excel in complex dynamic domains, such as manipulation tasks, but struggle with real-world issues like wear-and-tear, uncalibrated sensors, and misspecifications. These factors often perturb system dynamics, leading to the 'reality gap' problem when robots transition from simulations to real-world environments. This work aims to bridge this gap by combining RL and control in a learning framework that adapts MPC to robot decisions, optimizing performance despite uncertainties in dynamics model parameters. This thesis presents three key contributions to robotics control. The first is a novel reward-based framework for refining stochastic Model Predictive Control (MPC). It utilizes Bayesian Optimization (...
15
tesis de maestría
The field of autonomous driving has been evolving rapidly within the last few years and a lot of research has been dedicated towards the control of autonomous vehicles, especially car-like ones. Due to the recent successes of artificial intelligence techniques, even more complex problems can be solved, such as the control of autonomous multibody vehicles. Multibody vehicles can accomplish transportation tasks in a faster and cheaper way compared to multiple individual mobile vehicles or robots. But even for a human, driving a truck-trailer is a challenging task. This is because of the complex structure of the vehicle and the maneuvers that it has to perform, such as reverse parking to a loading dock. In addition, the detailed technical solution for an autonomous truck is challenging and even though many single-domain solutions are available, e.g. for pathplanning, no holistic framework e...
16
Publicado 2019
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The objective of this research work is to specify that the APOE methodology, the Van Hiele method and the use of the GeoGebra software, combined, should enhance the teaching-learning strategies, facilitating the work of both the teacher and the student. Everything is concentrated in example 2 on page 56, synthesizing, asking for the parametric and symmetric equations of the line that passes through two points A and B located in three-dimensional space, in part b) find the point of intersection of said straight line with plane x y, the latter has a high degree of complexity, the tools that a student must have to face this type of exercises are, obviously, intermediate level algebra as well as the use of trigonometry. Next, I will synthesize the procedures, this will serve as a roadmap which will make explicit what has been worked. First: we obtained the vector equation of the line. Second...
17
artículo
Publicado 2020
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The study of the complex ultracellular processes of nucleic acids is a subject debated as a scientific argument in favor of Intelligent Design (ID). The objective of this work was to analyze some molecular processes of the nucleic acids that suggest the confirmation of the ID theory, through the technique of documentary content analysis. First, the chemical structure of DNA and the combination of nitrogenous bases reflects that the genetic information of each created being is an original mixture of nitrogenous bases that makes each individual unique in the history of the world. Secondly, by studying the processes of DNA replication and repair, it is observed that each enzyme fulfills its function in a coordinated and organized manner avoiding the occurrence of errors and, should this occur, the cell has had very fine repair mechanisms. that correct these alterations in the best possible ...
18
artículo
Publicado 2020
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The study of the complex ultracellular processes of nucleic acids is a subject debated as a scientific argument in favor of Intelligent Design (ID). The objective of this work was to analyze some molecular processes of the nucleic acids that suggest the confirmation of the ID theory, through the technique of documentary content analysis. First, the chemical structure of DNA and the combination of nitrogenous bases reflects that the genetic information of each created being is an original mixture of nitrogenous bases that makes each individual unique in the history of the world. Secondly, by studying the processes of DNA replication and repair, it is observed that each enzyme fulfills its function in a coordinated and organized manner avoiding the occurrence of errors and, should this occur, the cell has had very fine repair mechanisms. that correct these alterations in the best possible ...
19
tesis de maestría
Publicado 2017
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Los índices de refracción complejos de películas delgadas de perovskitas de haluros mixtos de formamidinio-cesio de plomo (FA0.83Cs0.17Pb(I1 − xBrx)3), con composiciones variando de x = 0 a 0.4, y para topografías planas y de textura rugosa, son reportadas. Las películas se caracterizan por medio de una combinación de elipsometría espectral de ángulo variable y transmitancia espectral en el rango de longitudes de onda de 190 nm a 850 nm. Las constantes ópticas, espesores de las películas y las capas de microrugosidad, son determinadas con un método “punto a punto”, minimizando una función de error global, sin hacer uso de modelos de dispersión, e incluyendo información topográfica proporcionada por un microscopio con focal láser. Para evaluar el potencial de ingeniería del ancho de banda del material, sus anchos de banda y energías de Urbach son determinadas con e...
20
artículo
Dementia associated to human immunodeficiency virus infection (DHIV) is an entity distinguished by three main signs -cognitive, behavioral and motor symptoms- which generate serious difficulties in the functional capacity of the patient. The multiple denominations generate confusion and diagnostic difficulties. In spite of controversy in DHIV incidence, it is clear that more than 90% of patients with AIDS has compatible neuropathological anormalities with DHIV. The pathogenic mechanisms involve complex interactions between the HIV and the brain cells generating two inclusive paths, inflammatory and non inflammatory, that produce neurotoxic and chemotactic factors, inductors of apoptosis that lead to neuro-glial disruption probably responsible of injury and/or neuron cell death, that finally would lead to accelerated neurodegeneration phenomenon. Symptoms are subcortical dementia, mental ...
