Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats

• Autores: Ayala Pío, Salomón, Jurupe, Hilda, Díaz, David, Lock, Olga, Vega, María, Luque, Jorge, Garnique, Marco
• Formato: artículo
• Fecha de Publicación: 2001
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/4205
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205
• Nivel de acceso: acceso abierto
• Materia: Gastric mucosa; Plants; medicinal; Anti-ulcer agents; Disease models; animal; Mucosa gástrica; Plantas medicinales; Agentes antiulcerosos; Modelos animales de enfermedad

OBJECTIVE: The gastric protective abilities of dried sap and alkaloid fraction of Croton palanostigma and sucralfate against ethanol-induced necrosis was compared by means of standard experimental rat model. Subchronic toxicity was determined. MATERIAL AND METHODS: A pretreatment with either saline solution, dried sap of C. palanostigma 120 mg/kg, alkaloid fraction of C. palanostigma 20 mg/kg, 35 mg/kg y 50 mg/kg or sucralfate was given to 60 rats. Intragastric administration of 2 mL of 100% ethanol was accomplished one hour later. A gastrectomy was perfomed four hours later followed by macroscopic and histological evaluation of the gastric lesions. Subchronic toxicity was determined with doses of 0,12, 0,40 and 1,20 mL/kg of sap for a 30-day period with biochemical and histopathologic study of the organs. RESULTS: Pretreatment with dried sap and alkaloid fractions of C. palanostigma and sucralfate resulted in a significant reduction of ethanol-induced gastric mucosa necrosis. Subchronic toxicity with C. palanostigma largest dose showed risk of liver steatosis. CONCLUSION: In the present study, dried sap and alkaloid fraction of C. palanostigma and sucralfate showed a significative protective effect, being potentially useful as a therapeutic tool. Subchronic toxicity in higher doses showed risk of liver steatosis.