Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats

• Autores: Ayala Pío, Salomón, Díaz, David, Palomino, Manuel, Armas, Segundo, Paz, Juan
• Formato: artículo
• Fecha de Publicación: 1999
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/4498
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498
• Nivel de acceso: acceso abierto
• Materia: Gastric Mucosa; Plants; Medicinal; Anti-Ulcer Agents; Disease Models; Animal; Mucosa Gástrica; Plantas Medicinales; Agentes Antiulcerosos; Modelos Animales de Enfermedad

OBJECTIVE: The gastric protective abilities of Croton palanostigma (dragonis blood), Aloe vera, sucralfate, and antacid against acute ethanol-induced necrosis by means of a standard experimental model in rats, were compared. MATERIAL AND METHODS: A pretreatment with either saline solution; 0,8 mL/kg or 0,4 mL/kg C. palanostigma; 7,5 mL/kg or 3,2 mL/kg A. vera; 500 mg/kg sucralfate; or antacid was given to 56 fasted rats. Then we accomplished an intragastric administration of 2 mL of 100% ethanol one hour later. A gastrectomy was performed four hours later followed by a macroscopic and histologycal evaluation of the gastric lesions. RESULTS: C. palanostigma pretreatment resulted in a significant reduction of ethanol-induced gastric mucosa Protective effect of Croton palanostigma, Aloe vera, SUCRALFATE AND ANTACID AGAINST ACUTE ETHANOL-INDUCED GASTRIC MUCOSA necrosis. A. vera failed to show mucosal protection. Sucralfate showed a significant protective effect, while antacid exhibited a lesser protective effect. CONCLUSION: In the present study, C. palanostigma showed an important protective effect, being potentially useful as a therapeutic tool.